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| Drug Name | Ponatinib |
| Trade Name | Iclusig |
| Synonyms | AP24534 |
| Drug Descriptions |
Iclusig (ponatinib) inhibits the Bcr-Abl fusion, and other tyrosine kinases, such as RET, DDR, VEGFR, FGFR, KIT, and FLT3 (PMID: 23526464, PMID: 25284748, PMID: 19878872). Iclusig (ponatinib) is FDA approved for chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph positive ALL) as well as ABL1 T315I CML and ABL1 T315I Ph positive ALL (FDA.gov). |
| DrugClasses | ABL Inhibitor (pan) 9 BCR-ABL Inhibitor 28 DDR1 Inhibitor 8 DDR2 inhibitor 7 FGFR Inhibitor (Pan) 23 FLT3 Inhibitor 60 KIT Inhibitor 53 PDGFR-alpha Inhibitor 9 RET Inhibitor 45 SRC Inhibitor 31 VEGFR Inhibitor (Pan) 33 |
| CAS Registry Number | 943319-70-8 |
| NCIT ID | C95777 |
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