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Drug Name Ponatinib
Trade Name Iclusig
Synonyms AP24534
Drug Descriptions

Iclusig (ponatinib) inhibits the Bcr-Abl fusion, and other tyrosine kinases, such as RET, DDR, VEGFR, FGFR, KIT, and FLT3 (PMID: 23526464, PMID: 25284748, PMID: 19878872). Iclusig (ponatinib) is FDA approved for chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph positive ALL) as well as ABL1 T315I CML and ABL1 T315I Ph positive ALL (FDA.gov).

DrugClasses ABL Inhibitor (pan) 9 BCR-ABL Inhibitor 29 DDR1 Inhibitor 9 DDR2 inhibitor 7 FGFR Inhibitor (Pan) 25 FLT3 Inhibitor 64 KIT Inhibitor 56 PDGFR-alpha Inhibitor 9 RET Inhibitor 52 SRC Inhibitor 31 VEGFR Inhibitor (Pan) 36
CAS Registry Number 943319-70-8
NCIT ID C95777

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Asciminib + Hydroxyurea + Ponatinib Asciminib Hydroxyurea Ponatinib 0 0
Asciminib + Ponatinib Asciminib Ponatinib 0 0
Aspirin + Ponatinib Aspirin Ponatinib 0 1
Azacitidine + Ponatinib Azacitidine Ponatinib 0 2
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Cytarabine Dexamethasone Methotrexate Ponatinib 0 0
Blinatumomab + Cytarabine + Methotrexate + Ponatinib Blinatumomab Cytarabine Methotrexate Ponatinib 0 1
Blinatumomab + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Dexamethasone Methotrexate Ponatinib 0 0
Blinatumomab + Dexamethasone + Methotrexate + Ponatinib + Prednisone Blinatumomab Dexamethasone Methotrexate Ponatinib Prednisone 0 1
Blinatumomab + Dexamethasone + Ponatinib Blinatumomab Dexamethasone Ponatinib 0 0
Blinatumomab + Dexamethasone + Ponatinib + Prednisone Blinatumomab Dexamethasone Ponatinib Prednisone 0 1
Blinatumomab + Ponatinib Blinatumomab Ponatinib 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Methotrexate + Ponatinib + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Methotrexate Ponatinib Vincristine Sulfate 0 1
Cyclophosphamide + Dexamethasone + Doxorubicin + Ofatumumab + Ponatinib + Vincristine Sulfate Cyclophosphamide Dexamethasone Doxorubicin Ofatumumab Ponatinib Vincristine Sulfate 0 0
Cyclophosphamide + Dexamethasone + Doxorubicin + Ponatinib + Vincristine Sulfate Cyclophosphamide Dexamethasone Doxorubicin Ponatinib Vincristine Sulfate 0 1
Cytarabine + Dexamethasone + Methotrexate + Ponatinib + Rituximab + Venetoclax Cytarabine Dexamethasone Methotrexate Ponatinib Rituximab Venetoclax 0 0
Cytarabine + Methotrexate + Ponatinib Cytarabine Methotrexate Ponatinib 0 3
Decitabine + Ponatinib + Venetoclax Decitabine Ponatinib Venetoclax 0 1
Dexamethasone + Inotuzumab ozogamicin + Methotrexate + Ponatinib + Vincristine Sulfate Dexamethasone Inotuzumab ozogamicin Methotrexate Ponatinib Vincristine Sulfate 0 1
Dexamethasone + Ponatinib + Rituximab + Venetoclax Dexamethasone Ponatinib Rituximab Venetoclax 0 1
Dexamethasone + Ponatinib + Venetoclax Dexamethasone Ponatinib Venetoclax 0 1
Dexamethasone + Ponatinib + Vincristine Sulfate Dexamethasone Ponatinib Vincristine Sulfate 0 1
Imatinib + Ponatinib Imatinib Ponatinib 0 1
Inotuzumab ozogamicin + Ponatinib Inotuzumab ozogamicin Ponatinib 0 0
Leucovorin + Mercaptopurine + Methotrexate + Ponatinib Leucovorin Mercaptopurine Methotrexate Ponatinib 0 1
Lorlatinib + Ponatinib Lorlatinib Ponatinib 0 0
Mercaptopurine + Methotrexate + Ponatinib Mercaptopurine Methotrexate Ponatinib 0 1
MI-503 + Ponatinib MI-503 Ponatinib 0 0
PLX4720 + Ponatinib PLX4720 Ponatinib 1 0
Ponatinib Ponatinib 115 28
Ponatinib + Prednisone Ponatinib Prednisone 0 1
Ponatinib + Prednisone + Vincristine Sulfate Ponatinib Prednisone Vincristine Sulfate 0 1
Ponatinib + Sapanisertib Ponatinib Sapanisertib 0 0
Ponatinib + Saracatinib Ponatinib Saracatinib 0 0
Ponatinib + Trametinib Ponatinib Trametinib 0 1
Ponatinib + Vemurafenib Ponatinib Vemurafenib 1 0
Ponatinib + Venetoclax Ponatinib Venetoclax 0 0
Ponatinib + Vincristine Sulfate Ponatinib Vincristine Sulfate 0 1
Ponatinib + VTP50469 Ponatinib VTP50469 0 0


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