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Drug Name Ponatinib
Trade Name Iclusig
Synonyms AP24534
Drug Descriptions

Iclusig (ponatinib) inhibits the Bcr-Abl fusion, and other tyrosine kinases, such as RET, DDR, VEGFR, FGFR, KIT, and FLT3 (PMID: 23526464, PMID: 25284748, PMID: 19878872). Iclusig (ponatinib) is FDA approved for chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph positive ALL) as well as ABL1 T315I CML and ABL1 T315I Ph positive ALL (FDA.gov).

DrugClasses BCR-ABL Inhibitor 24 DDR1 Inhibitor 8 DDR2 inhibitor 7 FGFR Inhibitor (Pan) 18 FLT3 Inhibitor 53 KIT Inhibitor 50 PDGFR-alpha Inhibitor 9 RET Inhibitor 39 SRC Inhibitor 28 VEGFR Inhibitor (Pan) 32

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Asciminib + Ponatinib Asciminib Ponatinib 0 0
Azacitidine + Ponatinib Azacitidine Ponatinib 0 1
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Cytarabine Dexamethasone Methotrexate Ponatinib 0 1
Blinatumomab + Dexamethasone + Ponatinib Blinatumomab Dexamethasone Ponatinib 0 1
Cytarabine + Dexamethasone + Methotrexate + Ponatinib + Rituximab + Venetoclax Cytarabine Dexamethasone Methotrexate Ponatinib Rituximab Venetoclax 0 1
Cytarabine + Methotrexate + Ponatinib Cytarabine Methotrexate Ponatinib 0 2
Decitabine + Ponatinib + Venetoclax Decitabine Ponatinib Venetoclax 0 1
Dexamethasone + Ponatinib + Vincristine Sulfate Dexamethasone Ponatinib Vincristine Sulfate 0 1
Lorlatinib + Ponatinib Lorlatinib Ponatinib 0 0
PLX4720 + Ponatinib PLX4720 Ponatinib 1 0
Ponatinib Ponatinib 121 15
Ponatinib + Prednisone + Vincristine Sulfate Ponatinib Prednisone Vincristine Sulfate 0 1
Ponatinib + Sapanisertib Ponatinib Sapanisertib 2 0
Ponatinib + Saracatinib Ponatinib Saracatinib 0 0
Ponatinib + Trametinib Ponatinib Trametinib 0 1
Ponatinib + Vemurafenib Ponatinib Vemurafenib 1 0
Ponatinib + Venetoclax Ponatinib Venetoclax 0 0
Ponatinib + Vincristine Sulfate Ponatinib Vincristine Sulfate 0 1


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