Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Ponatinib
Trade Name Iclusig
Synonyms AP24534
Drug Descriptions

Iclusig (ponatinib) inhibits the Bcr-Abl fusion, and other tyrosine kinases, such as RET, DDR, VEGFR, FGFR, KIT, and FLT3 (PMID: 23526464, PMID: 25284748, PMID: 19878872). Iclusig (ponatinib) is FDA approved for chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph positive ALL) as well as ABL1 T315I CML and ABL1 T315I Ph positive ALL (FDA.gov).

DrugClasses BCR-ABL Inhibitor 24 DDR1 Inhibitor 8 DDR2 inhibitor 7 FGFR Inhibitor (Pan) 18 FLT3 Inhibitor 53 KIT Inhibitor 50 PDGFR-alpha Inhibitor 9 RET Inhibitor 39 SRC Inhibitor 28 VEGFR Inhibitor (Pan) 32


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Asciminib + Ponatinib Asciminib Ponatinib 0 0
Azacitidine + Ponatinib Azacitidine Ponatinib 0 1
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Cytarabine Dexamethasone Methotrexate Ponatinib 0 1
Blinatumomab + Dexamethasone + Ponatinib Blinatumomab Dexamethasone Ponatinib 0 1
Cytarabine + Dexamethasone + Methotrexate + Ponatinib + Rituximab + Venetoclax Cytarabine Dexamethasone Methotrexate Ponatinib Rituximab Venetoclax 0 1
Cytarabine + Methotrexate + Ponatinib Cytarabine Methotrexate Ponatinib 0 2
Decitabine + Ponatinib + Venetoclax Decitabine Ponatinib Venetoclax 0 1
Dexamethasone + Ponatinib + Vincristine Sulfate Dexamethasone Ponatinib Vincristine Sulfate 0 1
Lorlatinib + Ponatinib Lorlatinib Ponatinib 0 0
PLX4720 + Ponatinib PLX4720 Ponatinib 1 0
Ponatinib Ponatinib 121 15
Ponatinib + Prednisone + Vincristine Sulfate Ponatinib Prednisone Vincristine Sulfate 0 1
Ponatinib + Sapanisertib Ponatinib Sapanisertib 2 0
Ponatinib + Saracatinib Ponatinib Saracatinib 0 0
Ponatinib + Trametinib Ponatinib Trametinib 0 1
Ponatinib + Vemurafenib Ponatinib Vemurafenib 1 0
Ponatinib + Venetoclax Ponatinib Venetoclax 0 0
Ponatinib + Vincristine Sulfate Ponatinib Vincristine Sulfate 0 1

Additional content available in CKB BOOST