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| Drug Name | Ponatinib |
| Trade Name | Iclusig |
| Synonyms | AP24534 |
| Drug Descriptions |
Iclusig (ponatinib) inhibits the Bcr-Abl fusion, and other tyrosine kinases, such as RET, DDR, VEGFR, FGFR, KIT, and FLT3 (PMID: 23526464, PMID: 25284748, PMID: 19878872). Iclusig (ponatinib) is FDA approved for chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph positive ALL) as well as ABL1 T315I CML and ABL1 T315I Ph positive ALL (FDA.gov). |
| DrugClasses | BCR-ABL Inhibitor 26 DDR1 Inhibitor 8 DDR2 inhibitor 7 FGFR Inhibitor (Pan) 18 FLT3 Inhibitor 55 KIT Inhibitor 51 PDGFR-alpha Inhibitor 9 RET Inhibitor 39 SRC Inhibitor 29 VEGFR Inhibitor (Pan) 32 |
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