Drug Detail

Drug Name Ponatinib
Trade Name Iclusig
Synonyms AP24534
Drug Descriptions

Iclusig (ponatinib) inhibits the Bcr-Abl fusion, and other tyrosine kinases, such as RET, DDR, VEGFR, FGFR, KIT, and FLT3 (PMID: 23526464, PMID: 25284748, PMID: 19878872). Iclusig (ponatinib) is FDA approved for chronic myeloid leukemia (CML) and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph positive ALL) as well as ABL1 T315I CML and ABL1 T315I Ph positive ALL (FDA.gov).

DrugClasses BCR-ABL Inhibitor 24 DDR1 Inhibitor 8 DDR2 inhibitor 7 FGFR Inhibitor (Pan) 18 FLT3 Inhibitor 50 KIT Inhibitor 50 PDGFR-alpha Inhibitor 7 RET Inhibitor 36 SRC Inhibitor 27 VEGFR Inhibitor (Pan) 31

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Ponatinib Azacitidine Ponatinib 0 1
Blinatumomab + Cytarabine + Dexamethasone + Methotrexate + Ponatinib Blinatumomab Cytarabine Dexamethasone Methotrexate Ponatinib 0 1
Blinatumomab + Dexamethasone + Ponatinib Blinatumomab Dexamethasone Ponatinib 0 1
Cytarabine + Dexamethasone + Methotrexate + Ponatinib + Rituximab + Venetoclax Cytarabine Dexamethasone Methotrexate Ponatinib Rituximab Venetoclax 0 1
Cytarabine + Methotrexate + Ponatinib Cytarabine Methotrexate Ponatinib 0 2
Dexamethasone + Ponatinib + Vincristine Dexamethasone Ponatinib Vincristine 0 1
Ponatinib Ponatinib 115 15
Ponatinib + Prednisone + Vincristine Ponatinib Prednisone Vincristine 0 1
Ponatinib + Saracatinib Ponatinib Saracatinib 0 0
Ponatinib + Trametinib Ponatinib Trametinib 0 1
Ponatinib + Venetoclax Ponatinib Venetoclax 0 0
Ponatinib + Vincristine Ponatinib Vincristine 0 1


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