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Drug Name Lorlatinib
Trade Name Lorbrena
Synonyms PF-06463922
Drug Descriptions

Lorbrena (lorlatinib) is a small molecule inhibitor of Alk and Ros1 fusion proteins, which may result in suppression of Alk and Ros1-mediated signaling thereby inhibiting cell growth and causing tumor regression (PMID: 26144315). Lorbrena (lorlatinib) is FDA approved for use in patients with ALK-positive non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 22 ROS1 Inhibitor 14

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Binimetinib + Lorlatinib Binimetinib Lorlatinib 0 1
Capmatinib + Lorlatinib Capmatinib Lorlatinib 0 0
Carboplatin + Lorlatinib Carboplatin Lorlatinib 0 1
Cisplatin + Lorlatinib Cisplatin Lorlatinib 0 1
Crizotinib + Lorlatinib Crizotinib Lorlatinib 0 1
Cyclophosphamide + Lorlatinib + Topotecan Cyclophosphamide Lorlatinib Topotecan 0 1
Everolimus + Lorlatinib Everolimus Lorlatinib 0 0
Lorlatinib Lorlatinib 106 8
Lorlatinib + Ponatinib Lorlatinib Ponatinib 0 0
Lorlatinib + Saracatinib Lorlatinib Saracatinib 1 0
Lorlatinib + Savolitinib Lorlatinib Savolitinib 0 0
Lorlatinib + Trametinib Lorlatinib Trametinib 0 0
Lorlatinib + Vistusertib Lorlatinib Vistusertib 0 0


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