Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Lorlatinib
Trade Name Lorbrena
Synonyms PF-06463922|Lorviqua
Drug Descriptions

Lorbrena (lorlatinib) is a small molecule inhibitor of Alk and Ros1 fusion proteins, which may result in suppression of Alk and Ros1-mediated signaling thereby inhibiting cell growth and causing tumor regression (PMID: 26144315). Lorbrena (lorlatinib) is FDA approved for use in patients with ALK-positive non-small cell lung cancer (FDA.gov).

DrugClasses ALK Inhibitor 30 ROS1 Inhibitor 20
CAS Registry Number 1454846-35-5
NCIT ID C113655


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Lorlatinib Avelumab Lorlatinib 0 0
Bevacizumab + Lorlatinib Bevacizumab Lorlatinib 2 0
Binimetinib + Lorlatinib Binimetinib Lorlatinib 0 1
Capmatinib + Lorlatinib Capmatinib Lorlatinib 0 0
Carboplatin + Lorlatinib Carboplatin Lorlatinib 0 1
Cisplatin + Lorlatinib Cisplatin Lorlatinib 0 1
Crizotinib + Lorlatinib Crizotinib Lorlatinib 0 1
Cyclophosphamide + Doxorubicin + Lorlatinib + Vincristine Sulfate Cyclophosphamide Doxorubicin Lorlatinib Vincristine Sulfate 3 0
Cyclophosphamide + Lorlatinib + Topotecan Cyclophosphamide Lorlatinib Topotecan 0 1
Dasatinib + Lorlatinib Dasatinib Lorlatinib 0 0
Everolimus + Lorlatinib Everolimus Lorlatinib 0 0
Idasanutlin + Lorlatinib Idasanutlin Lorlatinib 2 0
Lorlatinib Lorlatinib 217 15
Lorlatinib + Olaparib Lorlatinib Olaparib 0 0
Lorlatinib + PF-07284892 Lorlatinib PF-07284892 0 1
Lorlatinib + Ponatinib Lorlatinib Ponatinib 0 0
Lorlatinib + Saracatinib Lorlatinib Saracatinib 2 0
Lorlatinib + Savolitinib Lorlatinib Savolitinib 0 0
Lorlatinib + Selumetinib Lorlatinib Selumetinib 0 0
Lorlatinib + Temozolomide Lorlatinib Temozolomide 0 1
Lorlatinib + Trametinib Lorlatinib Trametinib 0 0
Lorlatinib + Vistusertib Lorlatinib Vistusertib 0 0

Additional content available in CKB BOOST