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Drug Name Capmatinib
Trade Name Tabrecta
Synonyms INC280
Drug Descriptions

Tabrecta (capmatinib) inhibits MET signaling and may induce cell death in tumors overexpressing MET or expressing constitutively activated MET (PMID: 31853265). Tabrecta (capmatinib) is FDA approved for use in patients with metastatic non-small cell lung cancer harboring MET exon 14 skipping mutations (FDA.gov).

DrugClasses MET Inhibitor 55

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1155463 + Capmatinib A-1155463 Capmatinib 0 0
Afatinib + Capmatinib Afatinib Capmatinib 0 0
Alpelisib + Capmatinib Alpelisib Capmatinib 0 0
Bevacizumab + Capmatinib Bevacizumab Capmatinib 0 1
Binimetinib + Capmatinib + Encorafenib Binimetinib Capmatinib Encorafenib 0 1
Buparlisib + Capmatinib Buparlisib Capmatinib 0 1
Capmatinib Capmatinib 9 10
Capmatinib + Ceritinib Capmatinib Ceritinib 0 0
Capmatinib + Cetuximab Capmatinib Cetuximab 0 1
Capmatinib + Dabrafenib + Trametinib Capmatinib Dabrafenib Trametinib 0 0
Capmatinib + Docetaxel Capmatinib Docetaxel 0 0
Capmatinib + Encorafenib Capmatinib Encorafenib 0 1
Capmatinib + Erlotinib Capmatinib Erlotinib 0 1
Capmatinib + Gefitinib Capmatinib Gefitinib 0 0
Capmatinib + LAG525 + Spartalizumab Capmatinib LAG525 Spartalizumab 0 1
Capmatinib + Lapatinib Capmatinib Lapatinib 0 0
Capmatinib + Lorlatinib Capmatinib Lorlatinib 0 0
Capmatinib + Nazartinib Capmatinib Nazartinib 0 2
Capmatinib + Nivolumab Capmatinib Nivolumab 0 1
Capmatinib + S63845 Capmatinib S63845 0 0
Capmatinib + Spartalizumab Capmatinib Spartalizumab 0 3
Capmatinib + Trametinib Capmatinib Trametinib 0 0
Capmatinib + Venetoclax Capmatinib Venetoclax 0 0


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