Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Capmatinib
Trade Name Tabrecta
Synonyms INC280|INC-280|INCB028060|INCB28060|INCB 28060
Drug Descriptions

Tabrecta (capmatinib) inhibits MET signaling and may induce cell death in tumors overexpressing MET or expressing constitutively activated MET (PMID: 31853265). Tabrecta (capmatinib) is FDA approved for use in patients with metastatic non-small cell lung cancer harboring MET exon 14 skipping mutations (FDA.gov).

DrugClasses MET Inhibitor 51

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1155463 + Capmatinib A-1155463 Capmatinib 0 0
Afatinib + Capmatinib Afatinib Capmatinib 0 0
Alpelisib + Capmatinib Alpelisib Capmatinib 0 0
Bevacizumab + Capmatinib Bevacizumab Capmatinib 0 1
Binimetinib + Capmatinib + Encorafenib Binimetinib Capmatinib Encorafenib 0 1
Buparlisib + Capmatinib Buparlisib Capmatinib 0 1
Capmatinib Capmatinib 9 10
Capmatinib + Ceritinib Capmatinib Ceritinib 0 0
Capmatinib + Cetuximab Capmatinib Cetuximab 0 1
Capmatinib + Dabrafenib + Trametinib Capmatinib Dabrafenib Trametinib 0 0
Capmatinib + Docetaxel Capmatinib Docetaxel 0 0
Capmatinib + Encorafenib Capmatinib Encorafenib 0 1
Capmatinib + Erlotinib Capmatinib Erlotinib 0 2
Capmatinib + Gefitinib Capmatinib Gefitinib 0 1
Capmatinib + LAG525 + Spartalizumab Capmatinib LAG525 Spartalizumab 0 1
Capmatinib + Lapatinib Capmatinib Lapatinib 0 0
Capmatinib + Lorlatinib Capmatinib Lorlatinib 0 0
Capmatinib + Nazartinib Capmatinib Nazartinib 0 3
Capmatinib + Nivolumab Capmatinib Nivolumab 0 1
Capmatinib + S63845 Capmatinib S63845 0 0
Capmatinib + Spartalizumab Capmatinib Spartalizumab 0 3
Capmatinib + Trametinib Capmatinib Trametinib 0 0
Capmatinib + Venetoclax Capmatinib Venetoclax 0 0


Additional content available in CKB BOOST