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Drug Name ZW25
Trade Name
Synonyms ZW-25|Zanidatamab
Drug Descriptions

Zanidatamab (ZW25) is a bispecific antibody targeting ERBB2 (HER2), which induces anti-tumor immune response against Erbb2 (Her2)-expressing tumors (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 255P, PMID: 32054397).

DrugClasses HER2 (ERBB2) Antibody 73
CAS Registry Number 2169946-15-8
NCIT ID C130010

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + ZW25 Bevacizumab Fluorouracil Leucovorin Oxaliplatin ZW25 0 1
Capecitabine + Cisplatin + ZW25 Capecitabine Cisplatin ZW25 0 0
Capecitabine + Oxaliplatin + Tislelizumab + ZW25 Capecitabine Oxaliplatin Tislelizumab ZW25 0 1
Capecitabine + Oxaliplatin + ZW25 Capecitabine Oxaliplatin ZW25 0 2
Capecitabine + ZW25 Capecitabine ZW25 0 1
Capmatinib + ZW25 Capmatinib ZW25 0 0
Cisplatin + Durvalumab + Gemcitabine + ZW25 Cisplatin Durvalumab Gemcitabine ZW25 0 1
Cisplatin + Fluorouracil + Leucovorin + ZW25 Cisplatin Fluorouracil Leucovorin ZW25 0 0
Cisplatin + Fluorouracil + Tislelizumab + ZW25 Cisplatin Fluorouracil Tislelizumab ZW25 0 1
Cisplatin + Fluorouracil + ZW25 Cisplatin Fluorouracil ZW25 0 2
Cisplatin + Gemcitabine + Pembrolizumab + ZW25 Cisplatin Gemcitabine Pembrolizumab ZW25 0 1
Cisplatin + Gemcitabine + ZW25 Cisplatin Gemcitabine ZW25 0 1
Crizotinib + ZW25 Crizotinib ZW25 0 0
Docetaxel + ZW25 Docetaxel ZW25 0 0
Evorpacept + ZW25 Evorpacept ZW25 0 1
Fluorouracil + Leucovorin + Oxaliplatin + ZW25 Fluorouracil Leucovorin Oxaliplatin ZW25 0 1
Fulvestrant + Palbociclib + ZW25 Fulvestrant Palbociclib ZW25 0 1
JQ1 + ZW25 JQ1 ZW25 0 0
Letrozole + Tamoxifen + ZW25 Letrozole Tamoxifen ZW25 0 0
Letrozole + ZW25 Letrozole ZW25 0 1
Paclitaxel + Ramucirumab + ZW25 Paclitaxel Ramucirumab ZW25 0 1
Paclitaxel + ZW25 Paclitaxel ZW25 0 1
Tamoxifen + ZW25 Tamoxifen ZW25 0 1
Vinorelbine + ZW25 Vinorelbine ZW25 0 1
ZW25 ZW25 0 6


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