Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Palbociclib
Trade Name Ibrance
Synonyms PD0332991
Drug Descriptions

Ibrance (palbociclib) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) and 6 (CDK6) (PMID: 19874578). Ibrance (palbociclib) is approved in combination with an aromatase inhibitor in postmenopausal patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer, and in combination with Faslodex (fulvestrant) in patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer (FDA.gov).

DrugClasses CDK4/6 Inhibitor 9

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abexinostat + Fulvestrant + Palbociclib Abexinostat Fulvestrant Palbociclib 0 1
Ado-trastuzumab emtansine + Letrozole + Palbociclib Ado-trastuzumab emtansine Letrozole Palbociclib 0 1
Ado-trastuzumab emtansine + Palbociclib Ado-trastuzumab emtansine Palbociclib 0 2
Alisertib + Palbociclib Alisertib Palbociclib 2 0
Alvocidib + Palbociclib Alvocidib Palbociclib 0 0
Anakinra + Palbociclib + Trametinib Anakinra Palbociclib Trametinib 0 0
Anastrozole + Nivolumab + Palbociclib Anastrozole Nivolumab Palbociclib 0 1
Anastrozole + Palbociclib Anastrozole Palbociclib 0 4
Anastrozole + Palbociclib + Pertuzumab + Trastuzumab Anastrozole Palbociclib Pertuzumab Trastuzumab 0 1
Avelumab + Axitinib + Palbociclib Avelumab Axitinib Palbociclib 0 1
Avelumab + Cetuximab + Palbociclib Avelumab Cetuximab Palbociclib 0 1
Avelumab + Fulvestrant + Palbociclib Avelumab Fulvestrant Palbociclib 0 1
Avelumab + Palbociclib + Tamoxifen Avelumab Palbociclib Tamoxifen 0 1
AZD8055 + Palbociclib AZD8055 Palbociclib 0 0
AZD8835 + Fulvestrant + Palbociclib AZD8835 Fulvestrant Palbociclib 0 0
AZD8835 + Palbociclib AZD8835 Palbociclib 0 0
AZD9496 + Palbociclib AZD9496 Palbociclib 0 0
AZD9833 + Palbociclib AZD9833 Palbociclib 0 1
Bazedoxifene + Palbociclib Bazedoxifene Palbociclib 0 1
Bicalutamide + Palbociclib Bicalutamide Palbociclib 0 1
Binimetinib + Palbociclib Binimetinib Palbociclib 0 2
Bortezomib + Dasatinib + Dexamethasone + Doxorubicin + Palbociclib Bortezomib Dasatinib Dexamethasone Doxorubicin Palbociclib 0 1
Bortezomib + Palbociclib Bortezomib Palbociclib 0 1
Bosutinib + Fulvestrant + Palbociclib Bosutinib Fulvestrant Palbociclib 0 1
Bosutinib + Palbociclib Bosutinib Palbociclib 0 1
Buparlisib + Palbociclib Buparlisib Palbociclib 3 0
Carboplatin + Palbociclib Carboplatin Palbociclib 0 2
CCT137690 + Palbociclib CCT137690 Palbociclib 1 0
Cetuximab + Palbociclib Cetuximab Palbociclib 0 3
Cisplatin + Palbociclib Cisplatin Palbociclib 0 2
Copanlisib + Letrozole + Palbociclib Copanlisib Letrozole Palbociclib 0 1
CPX-351 + Palbociclib CPX-351 Palbociclib 0 1
Cytarabine + Doxorubicin + Palbociclib + Pegaspargase + Prednisolone + Vincristine Sulfate Cytarabine Doxorubicin Palbociclib Pegaspargase Prednisolone Vincristine Sulfate 0 1
Cytarabine + Doxorubicin + Palbociclib + Pegaspargase + Prednisone + Vincristine Sulfate Cytarabine Doxorubicin Palbociclib Pegaspargase Prednisone Vincristine Sulfate 0 1
D-0502 + Palbociclib D-0502 Palbociclib 0 1
Dactolisib + Palbociclib Dactolisib Palbociclib 0 0
Danusertib + Palbociclib Danusertib Palbociclib 2 0
Decitabine + Palbociclib Decitabine Palbociclib 0 1
Dexamethasone + Palbociclib Dexamethasone Palbociclib 0 2
Erdafitinib + Fulvestrant + Palbociclib Erdafitinib Fulvestrant Palbociclib 0 1
Everolimus + Exemestane + Palbociclib Everolimus Exemestane Palbociclib 0 1
Everolimus + Palbociclib Everolimus Palbociclib 2 0
Exemestane + Palbociclib Exemestane Palbociclib 0 1
Fluorouracil + Oxaliplatin + Palbociclib Fluorouracil Oxaliplatin Palbociclib 0 1
Fluorouracil + Palbociclib Fluorouracil Palbociclib 0 0
Fulvestrant + GDC-0077 + Palbociclib Fulvestrant GDC-0077 Palbociclib 0 1
Fulvestrant + Infigratinib + Palbociclib Fulvestrant Infigratinib Palbociclib 0 1
Fulvestrant + Ipatasertib + Palbociclib Fulvestrant Ipatasertib Palbociclib 0 2
Fulvestrant + Letrozole + Palbociclib Fulvestrant Letrozole Palbociclib 0 1
Fulvestrant + Lucitanib + Palbociclib Fulvestrant Lucitanib Palbociclib 0 0
Fulvestrant + Olaparib + Palbociclib Fulvestrant Olaparib Palbociclib 0 1
Fulvestrant + Palbociclib Fulvestrant Palbociclib 1 12
Fulvestrant + Palbociclib + Pictilisib Fulvestrant Palbociclib Pictilisib 0 0
Fulvestrant + Palbociclib + Vistusertib Fulvestrant Palbociclib Vistusertib 0 1
Fulvestrant + Palbociclib + ZW25 Fulvestrant Palbociclib ZW25 0 1
G1T48 + Palbociclib G1T48 Palbociclib 0 1
Ganitumab + Palbociclib Ganitumab Palbociclib 0 1
GDC-0077 + Letrozole + Palbociclib GDC-0077 Letrozole Palbociclib 0 1
GDC-0980 + Palbociclib GDC-0980 Palbociclib 0 0
GDC-9545 + Palbociclib GDC-9545 Palbociclib 0 1
Gedatolisib + Palbociclib Gedatolisib Palbociclib 0 2
Gemcitabine + Palbociclib Gemcitabine Palbociclib 1 0
Goserelin + Letrozole + Palbociclib Goserelin Letrozole Palbociclib 0 1
GSK2194069 + Palbociclib GSK2194069 Palbociclib 0 0
GSK2334470 + Palbociclib GSK2334470 Palbociclib 0 0
GSK461364 + Palbociclib GSK461364 Palbociclib 1 0
H3B-5942 + Palbociclib H3B-5942 Palbociclib 0 0
H3B-6527 + Palbociclib H3B-6527 Palbociclib 0 0
H3B-6545 + Palbociclib H3B-6545 Palbociclib 0 1
HMN-214 + Palbociclib HMN-214 Palbociclib 1 0
Hydroxychloroquine + Letrozole + Palbociclib Hydroxychloroquine Letrozole Palbociclib 0 1
Ibrutinib + Palbociclib Ibrutinib Palbociclib 1 2
Ipatasertib + Palbociclib Ipatasertib Palbociclib 1 0
Irinotecan + Palbociclib + Temozolomide Irinotecan Palbociclib Temozolomide 0 1
Lapatinib + Palbociclib Lapatinib Palbociclib 1 0
Letrozole + Palbociclib Letrozole Palbociclib 0 6
Letrozole + Palbociclib + Pembrolizumab Letrozole Palbociclib Pembrolizumab 0 1
Letrozole + Palbociclib + PF-06952229 Letrozole PF-06952229 Palbociclib 0 1
Letrozole + Palbociclib + Trastuzumab Letrozole Palbociclib Trastuzumab 0 1
Letrozole + Palbociclib + Tucatinib Letrozole Palbociclib Tucatinib 0 1
Linsitinib + Palbociclib Linsitinib Palbociclib 0 0
Mavelertinib + Palbociclib Mavelertinib Palbociclib 0 1
MK2206 + Palbociclib MK2206 Palbociclib 1 0
MRTX849 + Palbociclib MRTX849 Palbociclib 0 0
Nab-paclitaxel + Palbociclib Nab-paclitaxel Palbociclib 0 1
Neratinib + Palbociclib Neratinib Palbociclib 0 1
Paclitaxel + Palbociclib Paclitaxel Palbociclib 1 0
Palbociclib Palbociclib 45 35
Palbociclib + PD-0325901 PD-0325901 Palbociclib 2 1
Palbociclib + PD173074 PD173074 Palbociclib 0 0
Palbociclib + PF-04691502 PF-04691502 Palbociclib 2 0
Palbociclib + Pictilisib Palbociclib Pictilisib 3 0
Palbociclib + Pimasertib Palbociclib Pimasertib 0 0
Palbociclib + Pipendoxifene Palbociclib Pipendoxifene 0 0
Palbociclib + Quizartinib Palbociclib Quizartinib 1 0
Palbociclib + RAD140 Palbociclib RAD140 0 0
Palbociclib + Retifanlimab Palbociclib Retifanlimab 0 1
Palbociclib + Rigosertib Sodium Palbociclib Rigosertib Sodium 0 0
Palbociclib + SAR439859 Palbociclib SAR439859 0 1
Palbociclib + Selumetinib Palbociclib Selumetinib 0 0
Palbociclib + SGI-1776 Palbociclib SGI-1776 1 0
Palbociclib + Sirolimus Palbociclib Sirolimus 1 0
Palbociclib + Sorafenib Palbociclib Sorafenib 0 1
Palbociclib + Tamoxifen Palbociclib Tamoxifen 0 5
Palbociclib + Tandutinib Palbociclib Tandutinib 1 0
Palbociclib + Tanespimycin Palbociclib Tanespimycin 0 0
Palbociclib + TCS 359 Palbociclib TCS 359 2 0
Palbociclib + Telaglenastat Palbociclib Telaglenastat 0 1
Palbociclib + Tozasertib Palbociclib Tozasertib 0 0
Palbociclib + Trametinib Palbociclib Trametinib 10 1
Palbociclib + Trastuzumab Palbociclib Trastuzumab 1 0
Palbociclib + Ulixertinib Palbociclib Ulixertinib 0 1
Palbociclib + Vemurafenib Palbociclib Vemurafenib 0 0
Palbociclib + Vorinostat Palbociclib Vorinostat 0 0
Palbociclib + XAV939 Palbociclib XAV939 0 0
Palbociclib + ZN-c5 Palbociclib ZN-c5 0 1


Additional content available in CKB BOOST