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Drug Name Palbociclib
Trade Name Ibrance
Synonyms PD0332991|PD-0332991
Drug Descriptions

Ibrance (palbociclib) is a selective inhibitor of cyclin-dependent kinase 4 (CDK4) and 6 (CDK6) (PMID: 19874578). Ibrance (palbociclib) is approved in combination with an aromatase inhibitor in postmenopausal patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer, and in combination with Faslodex (fulvestrant) in patients with ER-positive, ERBB2 (HER2)-negative metastatic breast cancer (FDA.gov).

DrugClasses CDK4/6 Inhibitor 13
CAS Registry Number 571190-30-2
NCIT ID C49176

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abexinostat + Fulvestrant + Palbociclib Abexinostat Fulvestrant Palbociclib 0 1
Adagrasib + Palbociclib Adagrasib Palbociclib 0 1
Ado-trastuzumab emtansine + Letrozole + Palbociclib Ado-trastuzumab emtansine Letrozole Palbociclib 0 1
Ado-trastuzumab emtansine + Palbociclib Ado-trastuzumab emtansine Palbociclib 0 2
Alisertib + Palbociclib Alisertib Palbociclib 2 0
Alvocidib + Palbociclib Alvocidib Palbociclib 0 0
Amcenestrant + Goserelin + Palbociclib Amcenestrant Goserelin Palbociclib 0 1
Amcenestrant + Palbociclib Amcenestrant Palbociclib 0 2
Anakinra + Palbociclib + Trametinib Anakinra Palbociclib Trametinib 0 0
Anastrozole + Nivolumab + Palbociclib Anastrozole Nivolumab Palbociclib 0 1
Anastrozole + Palbociclib Anastrozole Palbociclib 0 9
Anastrozole + Palbociclib + Pertuzumab + Trastuzumab Anastrozole Palbociclib Pertuzumab Trastuzumab 0 1
Anastrozole + Palbociclib + Trastuzumab Anastrozole Palbociclib Trastuzumab 0 1
APG-2575 + Palbociclib APG-2575 Palbociclib 0 1
Apitolisib + Palbociclib Apitolisib Palbociclib 0 0
ARTS-021 + Fulvestrant + Palbociclib ARTS-021 Fulvestrant Palbociclib 0 1
ARTS-021 + Letrozole + Palbociclib ARTS-021 Letrozole Palbociclib 0 1
ARTS-021 + Palbociclib ARTS-021 Palbociclib 0 0
Avelumab + Axitinib + Palbociclib Avelumab Axitinib Palbociclib 0 2
Avelumab + Cetuximab + Palbociclib Avelumab Cetuximab Palbociclib 0 1
Avelumab + Fulvestrant + Palbociclib Avelumab Fulvestrant Palbociclib 0 1
Avelumab + Goserelin + Palbociclib Avelumab Goserelin Palbociclib 0 1
Avelumab + Hydroxychloroquine + Palbociclib Avelumab Hydroxychloroquine Palbociclib 0 0
Avelumab + Leuprolide + Palbociclib Avelumab Leuprolide Palbociclib 0 1
Avelumab + Palbociclib Avelumab Palbociclib 0 2
Avelumab + Palbociclib + Tamoxifen Avelumab Palbociclib Tamoxifen 0 1
AZD4573 + Fulvestrant + Palbociclib AZD4573 Fulvestrant Palbociclib 0 0
AZD4573 + Palbociclib AZD4573 Palbociclib 0 0
AZD8055 + Palbociclib AZD8055 Palbociclib 0 0
AZD8421 + Camizestrant + Palbociclib AZD8421 Camizestrant Palbociclib 0 1
AZD8421 + Palbociclib AZD8421 Palbociclib 0 0
AZD8835 + Fulvestrant + Palbociclib AZD8835 Fulvestrant Palbociclib 0 0
AZD8835 + Palbociclib AZD8835 Palbociclib 0 0
AZD9496 + Palbociclib AZD9496 Palbociclib 0 0
BAY-293 + Palbociclib BAY-293 Palbociclib 0 0
Bazedoxifene + Palbociclib Bazedoxifene Palbociclib 0 1
Belzutifan + Palbociclib Belzutifan Palbociclib 0 1
Bicalutamide + Palbociclib Bicalutamide Palbociclib 0 1
Binimetinib + Encorafenib + Palbociclib Binimetinib Encorafenib Palbociclib 0 1
Binimetinib + Palbociclib Binimetinib Palbociclib 0 6
Bortezomib + Dasatinib + Dexamethasone + Doxorubicin + Palbociclib Bortezomib Dasatinib Dexamethasone Doxorubicin Palbociclib 0 1
Bortezomib + Dexamethasone + Doxorubicin + Palbociclib Bortezomib Dexamethasone Doxorubicin Palbociclib 0 1
Bortezomib + Palbociclib Bortezomib Palbociclib 0 1
Bosutinib + Fulvestrant + Palbociclib Bosutinib Fulvestrant Palbociclib 0 1
Bosutinib + Palbociclib Bosutinib Palbociclib 0 1
Buparlisib + Palbociclib Buparlisib Palbociclib 4 0
C188-9 + Palbociclib C188-9 Palbociclib 0 1
Camizestrant + Capivasertib + Palbociclib Camizestrant Capivasertib Palbociclib 0 0
Camizestrant + Palbociclib Camizestrant Palbociclib 0 4
Capivasertib + Fulvestrant + Palbociclib Capivasertib Fulvestrant Palbociclib 0 1
Carboplatin + Palbociclib Carboplatin Palbociclib 0 2
CCT137690 + Palbociclib CCT137690 Palbociclib 1 0
Cemiplimab + Palbociclib Cemiplimab Palbociclib 0 1
Cetuximab + Palbociclib Cetuximab Palbociclib 1 5
Cetuximab + Palbociclib + Radiotherapy Cetuximab Palbociclib Radiotherapy 0 0
Chloroquine + Palbociclib + Trametinib Chloroquine Palbociclib Trametinib 0 0
Cisplatin + Palbociclib Cisplatin Palbociclib 0 2
Copanlisib + Letrozole + Palbociclib Copanlisib Letrozole Palbociclib 0 1
CPX-351 + Palbociclib CPX-351 Palbociclib 0 1
CPX-351 + Palbociclib + Tazemetostat CPX-351 Palbociclib Tazemetostat 0 1
Crenolanib + Palbociclib Crenolanib Palbociclib 0 0
Crizotinib + Palbociclib Crizotinib Palbociclib 0 0
Cytarabine + Doxorubicin + Palbociclib + Pegaspargase + Prednisolone + Vincristine Sulfate Cytarabine Doxorubicin Palbociclib Pegaspargase Prednisolone Vincristine Sulfate 0 1
Cytarabine + Doxorubicin + Palbociclib + Pegaspargase + Prednisone + Vincristine Sulfate Cytarabine Doxorubicin Palbociclib Pegaspargase Prednisone Vincristine Sulfate 0 1
D-0502 + Palbociclib D-0502 Palbociclib 0 1
Dabrafenib + Palbociclib + Trametinib Dabrafenib Palbociclib Trametinib 1 0
Dactolisib + Palbociclib Dactolisib Palbociclib 0 0
Danusertib + Palbociclib Danusertib Palbociclib 2 0
Decitabine + Palbociclib Decitabine Palbociclib 0 1
Dexamethasone + Palbociclib Dexamethasone Palbociclib 0 2
Elacestrant + Palbociclib Elacestrant Palbociclib 0 2
Enzalutamide + Palbociclib Enzalutamide Palbociclib 0 0
EPI-7170 + Palbociclib EPI-7170 Palbociclib 0 0
ERAS-007 + Palbociclib ERAS-007 Palbociclib 0 1
Erdafitinib + Fulvestrant + Palbociclib Erdafitinib Fulvestrant Palbociclib 0 1
Erlotinib + Palbociclib Erlotinib Palbociclib 0 0
Everolimus + Exemestane + Palbociclib Everolimus Exemestane Palbociclib 0 1
Everolimus + Palbociclib Everolimus Palbociclib 2 0
Exemestane + Palbociclib Exemestane Palbociclib 0 4
Exemestane + Palbociclib + Trastuzumab Exemestane Palbociclib Trastuzumab 0 1
Fluorouracil + Oxaliplatin + Palbociclib Fluorouracil Oxaliplatin Palbociclib 0 1
Fluorouracil + Palbociclib Fluorouracil Palbociclib 0 0
Fulvestrant + Gedatolisib + Palbociclib Fulvestrant Gedatolisib Palbociclib 0 1
Fulvestrant + Inavolisib + Palbociclib Fulvestrant Inavolisib Palbociclib 0 1
Fulvestrant + Infigratinib + Palbociclib Fulvestrant Infigratinib Palbociclib 0 1
Fulvestrant + Ipatasertib + Palbociclib Fulvestrant Ipatasertib Palbociclib 0 3
Fulvestrant + Letrozole + Palbociclib Fulvestrant Letrozole Palbociclib 0 1
Fulvestrant + Lucitanib + Palbociclib Fulvestrant Lucitanib Palbociclib 0 0
Fulvestrant + Olaparib + Palbociclib Fulvestrant Olaparib Palbociclib 0 1
Fulvestrant + Palbociclib Fulvestrant Palbociclib 2 24
Fulvestrant + Palbociclib + PD173074 Fulvestrant PD173074 Palbociclib 0 0
Fulvestrant + Palbociclib + Pembrolizumab Fulvestrant Palbociclib Pembrolizumab 0 1
Fulvestrant + Palbociclib + PF-07248144 Fulvestrant PF-07248144 Palbociclib 0 1
Fulvestrant + Palbociclib + Pictilisib Fulvestrant Palbociclib Pictilisib 0 0
Fulvestrant + Palbociclib + RLY-5836 Fulvestrant Palbociclib RLY-5836 0 1
Fulvestrant + Palbociclib + Rogaratinib Fulvestrant Palbociclib Rogaratinib 0 1
Fulvestrant + Palbociclib + SHP099 Fulvestrant Palbociclib SHP099 0 0
Fulvestrant + Palbociclib + SHP099 + Trametinib Fulvestrant Palbociclib SHP099 Trametinib 0 0
Fulvestrant + Palbociclib + Taselisib Fulvestrant Palbociclib Taselisib 0 0
Fulvestrant + Palbociclib + Trametinib Fulvestrant Palbociclib Trametinib 0 0
Fulvestrant + Palbociclib + Trastuzumab Fulvestrant Palbociclib Trastuzumab 0 1
Fulvestrant + Palbociclib + Tucatinib Fulvestrant Palbociclib Tucatinib 0 0
Fulvestrant + Palbociclib + Vistusertib Fulvestrant Palbociclib Vistusertib 0 1
Fulvestrant + Palbociclib + Volasertib Fulvestrant Palbociclib Volasertib 0 0
Fulvestrant + Palbociclib + ZW25 Fulvestrant Palbociclib ZW25 0 1
G1T48 + Palbociclib G1T48 Palbociclib 0 1
Ganitumab + Palbociclib Ganitumab Palbociclib 0 1
Gedatolisib + Palbociclib Gedatolisib Palbociclib 2 2
Gemcitabine + Palbociclib Gemcitabine Palbociclib 1 0
Gilteritinib + Palbociclib Gilteritinib Palbociclib 0 0
Giredestrant + Palbociclib Giredestrant Palbociclib 0 4
Goserelin + Letrozole + Palbociclib Goserelin Letrozole Palbociclib 0 2
Goserelin + Palbociclib Goserelin Palbociclib 0 1
GSK2194069 + Palbociclib GSK2194069 Palbociclib 0 0
GSK2334470 + Palbociclib GSK2334470 Palbociclib 0 0
GSK461364 + Palbociclib GSK461364 Palbociclib 1 0
H3B-5942 + Palbociclib H3B-5942 Palbociclib 0 0
H3B-6527 + Palbociclib H3B-6527 Palbociclib 0 0
H3B-6545 + Palbociclib H3B-6545 Palbociclib 0 1
HMN-214 + Palbociclib HMN-214 Palbociclib 1 0
Hydroxychloroquine + Letrozole + Palbociclib Hydroxychloroquine Letrozole Palbociclib 0 1
Hydroxychloroquine + Palbociclib Hydroxychloroquine Palbociclib 0 1
IACS-13909 + Palbociclib + Trametinib IACS-13909 Palbociclib Trametinib 0 0
Ibrutinib + Palbociclib Ibrutinib Palbociclib 0 2
Inavolisib + Letrozole + Palbociclib Inavolisib Letrozole Palbociclib 0 1
Ipatasertib + Palbociclib Ipatasertib Palbociclib 2 0
Irinotecan + Palbociclib + Temozolomide Irinotecan Palbociclib Temozolomide 0 1
JQ1 + Palbociclib JQ1 Palbociclib 0 0
Lapatinib + Palbociclib Lapatinib Palbociclib 0 0
Lenvatinib + Palbociclib Lenvatinib Palbociclib 0 0
Letrozole + Onapristone + Palbociclib Letrozole Onapristone Palbociclib 0 1
Letrozole + Palbociclib Letrozole Palbociclib 0 18
Letrozole + Palbociclib + Pembrolizumab Letrozole Palbociclib Pembrolizumab 0 1
Letrozole + Palbociclib + Pertuzumab + Trastuzumab Letrozole Palbociclib Pertuzumab Trastuzumab 0 1
Letrozole + Palbociclib + PF-06804103 Letrozole PF-06804103 Palbociclib 0 1
Letrozole + Palbociclib + PF-06952229 Letrozole PF-06952229 Palbociclib 0 1
Letrozole + Palbociclib + PF-07104091 Letrozole PF-07104091 Palbociclib 0 1
Letrozole + Palbociclib + PF-07248144 Letrozole PF-07248144 Palbociclib 0 1
Letrozole + Palbociclib + Trastuzumab Letrozole Palbociclib Trastuzumab 0 2
Letrozole + Palbociclib + Tucatinib Letrozole Palbociclib Tucatinib 0 1
Letrozole + Palbociclib + Venetoclax Letrozole Palbociclib Venetoclax 0 1
Leuprolide + Palbociclib Leuprolide Palbociclib 0 1
Linsitinib + Palbociclib Linsitinib Palbociclib 0 0
Mavelertinib + Palbociclib Mavelertinib Palbociclib 0 1
Midostaurin + Palbociclib Midostaurin Palbociclib 0 0
MK2206 + Palbociclib MK2206 Palbociclib 2 0
Molibresib + Palbociclib Molibresib Palbociclib 0 0
Nab-paclitaxel + Palbociclib Nab-paclitaxel Palbociclib 0 1
NEO2734 + Palbociclib NEO2734 Palbociclib 0 0
Neratinib + Palbociclib Neratinib Palbociclib 0 3
NKT2152 + Palbociclib NKT2152 Palbociclib 0 1
NKT2152 + Palbociclib + PF-06801591 NKT2152 PF-06801591 Palbociclib 0 1
Osimertinib + Palbociclib Osimertinib Palbociclib 0 0
Paclitaxel + Palbociclib Paclitaxel Palbociclib 1 0
Palazestrant + Palbociclib Palazestrant Palbociclib 0 1
Palbociclib Palbociclib 46 53
Palbociclib + PD-0325901 PD-0325901 Palbociclib 4 1
Palbociclib + PD-0325901 + unspecified PD-L1 antibody PD-0325901 Palbociclib unspecified PD-L1 antibody 0 0
Palbociclib + PD173074 PD173074 Palbociclib 0 0
Palbociclib + Pembrolizumab Palbociclib Pembrolizumab 0 1
Palbociclib + Pexidartinib Palbociclib Pexidartinib 0 0
Palbociclib + PF-04691502 PF-04691502 Palbociclib 2 0
Palbociclib + PF-06801591 PF-06801591 Palbociclib 0 1
Palbociclib + PF-07104091 PF-07104091 Palbociclib 0 1
Palbociclib + Pictilisib Palbociclib Pictilisib 3 0
Palbociclib + Pimasertib Palbociclib Pimasertib 0 0
Palbociclib + Pimitespib Palbociclib Pimitespib 0 1
Palbociclib + Pipendoxifene Palbociclib Pipendoxifene 0 0
Palbociclib + Pralsetinib Palbociclib Pralsetinib 0 0
Palbociclib + Quisinostat Palbociclib Quisinostat 0 0
Palbociclib + Quizartinib Palbociclib Quizartinib 1 0
Palbociclib + RAD140 Palbociclib RAD140 0 0
Palbociclib + Retifanlimab Palbociclib Retifanlimab 0 1
Palbociclib + Rigosertib Sodium Palbociclib Rigosertib Sodium 0 0
Palbociclib + SCH772984 Palbociclib SCH772984 0 0
Palbociclib + Selumetinib Palbociclib Selumetinib 0 0
Palbociclib + SGI-1776 Palbociclib SGI-1776 1 0
Palbociclib + Sirolimus Palbociclib Sirolimus 1 0
Palbociclib + Sorafenib Palbociclib Sorafenib 0 1
Palbociclib + Sotorasib Palbociclib Sotorasib 0 1
Palbociclib + STX-478 Palbociclib STX-478 0 0
Palbociclib + Talazoparib Palbociclib Talazoparib 0 1
Palbociclib + Tamoxifen Palbociclib Tamoxifen 0 7
Palbociclib + Tamoxifen + Trastuzumab Palbociclib Tamoxifen Trastuzumab 0 1
Palbociclib + Tandutinib Palbociclib Tandutinib 1 0
Palbociclib + Tanespimycin Palbociclib Tanespimycin 0 0
Palbociclib + Taselisib Palbociclib Taselisib 2 0
Palbociclib + TCS 359 Palbociclib TCS 359 2 0
Palbociclib + Telaglenastat Palbociclib Telaglenastat 0 1
Palbociclib + Tozasertib Palbociclib Tozasertib 0 0
Palbociclib + Trametinib Palbociclib Trametinib 11 1
Palbociclib + Trastuzumab Palbociclib Trastuzumab 0 1
Palbociclib + Ulixertinib Palbociclib Ulixertinib 1 1
Palbociclib + Vemurafenib Palbociclib Vemurafenib 2 0
Palbociclib + Vepdegestrant Palbociclib Vepdegestrant 0 2
Palbociclib + Vorinostat Palbociclib Vorinostat 0 0
Palbociclib + XAV939 Palbociclib XAV939 0 0
Palbociclib + ZB716 Palbociclib ZB716 0 1
Palbociclib + ZN-c5 Palbociclib ZN-c5 0 1


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