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Drug Name APG-2575
Trade Name
Synonyms APG 2575|APG2575|Lisaftoclax
Drug Descriptions

APG-2575 is a small molecule that inhibits BCL-2, potentially resulting in increased apoptosis and enhanced antitumor activity in combination with other agents (PMID: 32093809, PMID: 37074726).

DrugClasses BCL2 inhibitor 27
CAS Registry Number 2180923-05-9
NCIT ID C156249


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Therapy Name Drugs Efficacy Evidence Clinical Trials
APG-115 + APG-2575 APG-115 APG-2575 0 1
APG-2575 APG-2575 0 3
APG-2575 + Azacitidine APG-2575 Azacitidine 0 1
APG-2575 + Daratumumab + Dexamethasone + Lenalidomide APG-2575 Daratumumab Dexamethasone Lenalidomide 0 1
APG-2575 + Decitabine + HQP1351 APG-2575 Decitabine HQP1351 0 1
APG-2575 + Dexamethasone + Lenalidomide APG-2575 Dexamethasone Lenalidomide 0 1
APG-2575 + Dexamethasone + Pomalidomide APG-2575 Dexamethasone Pomalidomide 0 1
APG-2575 + HQP1351 APG-2575 HQP1351 1 0
APG-2575 + Ibrutinib APG-2575 Ibrutinib 0 0
APG-2575 + Palbociclib APG-2575 Palbociclib 0 1
APG-2575 + Quizartinib APG-2575 Quizartinib 0 0
APG-2575 + unspecified immune checkpoint inhibitor APG-2575 unspecified immune checkpoint inhibitor 0 0
APG-2575 + unspecified PD-1 antibody APG-2575 unspecified PD-1 antibody 0 0

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