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Drug Name HQP1351
Trade Name
Synonyms HQP 1351|HQP-1351|GZD824 dimesylate|GZD824
Drug Descriptions

GZD824 (HQP1351) is a third-generation BCR-ABL inhibitor and multikinase inhibitor that inhibits KIT, ABL1, FGFR1, FLT3, and PDGFRA (PMID: 32247263), which potentially induces apoptosis, and inhibits tumor cell growth, migration, and invasion (PMID: 31673329).

DrugClasses ABL1 Inhibitor 6 FGFR1 Inhibitor 23 FLT3 Inhibitor 55 KIT Inhibitor 51 PDGFR-alpha Inhibitor 9
CAS Registry Number 1421783-64-3
NCIT ID C165549

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Therapy Name Drugs Efficacy Evidence Clinical Trials
BGT226 + HQP1351 BGT226 HQP1351 0 0
GSK690693 + HQP1351 GSK690693 HQP1351 0 0
HQP1351 HQP1351 20 1
HQP1351 + Torin 2 HQP1351 Torin 2 0 0
HQP1351 + ZSTK474 HQP1351 ZSTK474 0 0


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