Drug Detail


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Drug Name HQP1351
Trade Name
Synonyms HQP 1351|HQP-1351|GZD824 dimesylate|GZD824|Olverembatinib
Drug Descriptions

GZD824 (HQP1351) is a third-generation BCR-ABL inhibitor and multikinase inhibitor that inhibits KIT, ABL1, FGFR1, FLT3, and PDGFRA (PMID: 32247263), which potentially induces apoptosis, and inhibits tumor cell growth, migration, and invasion (PMID: 31673329).

DrugClasses ABL1 Inhibitor 8 FGFR1 Inhibitor 28 FLT3 Inhibitor 66 KIT Inhibitor 57 PDGFR-alpha Inhibitor 9
CAS Registry Number 1421783-64-3
NCIT ID C165549


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Therapy Name Drugs Efficacy Evidence Clinical Trials
APG-2575 + Decitabine + HQP1351 APG-2575 Decitabine HQP1351 0 1
APG-2575 + HQP1351 APG-2575 HQP1351 1 0
BGT226 + HQP1351 BGT226 HQP1351 0 0
Bosutinib + HQP1351 Bosutinib HQP1351 0 1
GSK690693 + HQP1351 GSK690693 HQP1351 0 0
HQP1351 HQP1351 26 2
HQP1351 + Torin 2 HQP1351 Torin 2 0 0
HQP1351 + ZSTK474 HQP1351 ZSTK474 0 0

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