Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name ZSTK474
Trade Name
Synonyms ZSTK-474
Drug Descriptions

ZSTK474 is a pan-PI3K inhibitor, which blocks PI3K/AKT signaling to prevent cell growth (PMID: 16622124, PMID: 30205797).

DrugClasses PI3K Inhibitor (Pan) 40
CAS Registry Number 475110-96-4
NCIT ID C95723

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
HQP1351 + ZSTK474 HQP1351 ZSTK474 0 0
Imatinib + ZSTK474 Imatinib ZSTK474 0 0
Nilotinib + ZSTK474 Nilotinib ZSTK474 0 0
PD-0325901 + ZSTK474 PD-0325901 ZSTK474 0 0
R11.1.6 + ZSTK474 R11.1.6 ZSTK474 0 0
Ruxolitinib + ZSTK474 Ruxolitinib ZSTK474 2 0
Selumetinib + ZSTK474 Selumetinib ZSTK474 1 0
Vemurafenib + ZSTK474 Vemurafenib ZSTK474 1 0
ZSTK474 ZSTK474 0 0


Additional content available in CKB BOOST