Drug Detail


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Drug Name Nilotinib
Trade Name Tasigna
Synonyms AMN-107|AMN107
Drug Descriptions

Tasigna (nilotinib) inhibits several tyrosine kinases including BCR-ABL, PDGFR, KIT, DDR and CSF-1R, potentially resulting in reduced tumor cell proliferation (PMID: 21419934, PMID: 25284748). Tasigna (nilotinib) is FDA approved for use in patients with Ph+ (BCR-ABL1) chronic myeloid leukemia (FDA.gov).

DrugClasses ABL Inhibitor (pan) 8 BCR-ABL Inhibitor 27 CSF1R Inhibitor 26 DDR1 Inhibitor 8 DDR2 inhibitor 7 KIT Inhibitor 51 PDGFR Inhibitor (Pan) 27
CAS Registry Number 641571-10-0
NCIT ID C48375


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Asciminib + Nilotinib Asciminib Nilotinib 0 1
BGT226 + Nilotinib BGT226 Nilotinib 0 0
Binimetinib + Nilotinib Binimetinib Nilotinib 0 1
Cetuximab + Nilotinib Cetuximab Nilotinib 0 1
Doxorubicin + Nilotinib Doxorubicin Nilotinib 4 0
GSK690693 + Nilotinib GSK690693 Nilotinib 0 0
Interferon alpha-2b + Nilotinib Interferon alpha-2b Nilotinib 0 1
Nab-paclitaxel + Nilotinib Nab-paclitaxel Nilotinib 0 1
Nilotinib Nilotinib 27 24
Nilotinib + Paclitaxel Nilotinib Paclitaxel 0 1
Nilotinib + Pembrolizumab Nilotinib Pembrolizumab 0 1
Nilotinib + Ruxolitinib Nilotinib Ruxolitinib 0 5
Nilotinib + Saracatinib Nilotinib Saracatinib 0 0
Nilotinib + SCH772984 Nilotinib SCH772984 0 0
Nilotinib + Tazemetostat Nilotinib Tazemetostat 1 0
Nilotinib + Torin 2 Nilotinib Torin 2 0 0
Nilotinib + Venetoclax Nilotinib Venetoclax 0 0
Nilotinib + ZSTK474 Nilotinib ZSTK474 0 0

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