Drug Detail

Drug Name AMG 232
Trade Name
Synonyms AMG-232
Drug Descriptions

AMG 232 is a potent inhibitor of the MDM2-p53 interaction, and inhibits proliferation of tumor cells in a p53 dependent manner (PMID: 24456472).

DrugClasses MDM2 Inhibitor 20

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AMG 232 AMG 232 10 4
AMG 232 + Carboplatin AMG 232 Carboplatin 1 0
AMG 232 + Carfilzomib + Dexamethasone + Lenalidomide AMG 232 Carfilzomib Dexamethasone Lenalidomide 0 1
AMG 232 + Cisplatin AMG 232 Cisplatin 1 0
AMG 232 + Dabrafenib + Trametinib AMG 232 Dabrafenib Trametinib 1 1
AMG 232 + Decitabine AMG 232 Decitabine 0 1
AMG 232 + Doxorubicin AMG 232 Doxorubicin 0 0
AMG 232 + Irinotecan AMG 232 Irinotecan 0 0
AMG 232 + Radiotherapy AMG 232 Radiotherapy 6 0
AMG 232 + Trametinib AMG 232 Trametinib 1 1


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