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Drug Name KRT-232
Trade Name
Synonyms KRT 232|KRT232|AMG232|AMG 232|AMG-232
Drug Descriptions

KRT-232 (AMG 232) is a potent inhibitor of the MDM2-p53 interaction, and inhibits proliferation of tumor cells in a p53 dependent manner (PMID: 24456472, PMID: 32234759).

DrugClasses MDM2 Inhibitor 20
CAS Registry Number 1352066-68-2
NCIT ID C156415


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + KRT-232 Acalabrutinib KRT-232 0 1
Carboplatin + KRT-232 Carboplatin KRT-232 1 0
Carfilzomib + Dexamethasone + KRT-232 + Lenalidomide Carfilzomib Dexamethasone KRT-232 Lenalidomide 0 1
Cisplatin + KRT-232 Cisplatin KRT-232 1 0
Cytarabine + Idarubicin + KRT-232 Cytarabine Idarubicin KRT-232 0 1
Cytarabine + KRT-232 Cytarabine KRT-232 0 1
Dabrafenib + KRT-232 + Trametinib Dabrafenib KRT-232 Trametinib 1 1
Decitabine + KRT-232 Decitabine KRT-232 0 2
Doxorubicin + KRT-232 Doxorubicin KRT-232 0 0
Irinotecan + KRT-232 Irinotecan KRT-232 0 0
KRT-232 KRT-232 14 8
KRT-232 + Pembrolizumab KRT-232 Pembrolizumab 0 0
KRT-232 + Radiotherapy KRT-232 Radiotherapy 6 0
KRT-232 + Ruxolitinib KRT-232 Ruxolitinib 0 1
KRT-232 + Trametinib KRT-232 Trametinib 1 1

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