Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Dabrafenib
Trade Name Tafinlar
Synonyms GSK2118436
Drug Descriptions

Tafinlar (dabrafenib) inhibits the activity of BRAF, including V600E, which results in inhibition of tumor cell proliferation (PMID: 22735384). Tafinlar (dabrafenib) is FDA approved for BRAF V600E positive unresectable or metastatic melanoma, and in combination with Mekinist (trametinib) for BRAF V600E/K-mutant melanoma, BRAF V600E-mutant non-small cell lung cancer, and BRAF V600E-mutant anaplastic thyroid cancer (FDA.gov).

DrugClasses BRAF Inhibitor 20

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + Dabrafenib + Trametinib 6MHP vaccine Dabrafenib Trametinib 0 1
Afatinib + Dabrafenib Afatinib Dabrafenib 0 0
Alpelisib + Dabrafenib + Erlotinib + Navitoclax Alpelisib Dabrafenib Erlotinib Navitoclax 0 0
Altiratinib + Dabrafenib Altiratinib Dabrafenib 0 0
Capmatinib + Dabrafenib + Trametinib Capmatinib Dabrafenib Trametinib 0 0
Cemiplimab + Dabrafenib + Trametinib Cemiplimab Dabrafenib Trametinib 0 1
Cetuximab + Dabrafenib Cetuximab Dabrafenib 2 0
Cetuximab + Dabrafenib + SCH772984 Cetuximab Dabrafenib SCH772984 2 0
Cetuximab + Dabrafenib + Trametinib Cetuximab Dabrafenib Trametinib 3 0
CGM097 + Dabrafenib + Navitoclax + PF-04217903 CGM097 Dabrafenib Navitoclax PF-04217903 0 0
Dabrafenib Dabrafenib 55 15
Dabrafenib + Digoxin + Trametinib Dabrafenib Digoxin Trametinib 0 1
Dabrafenib + Durvalumab + Trametinib Dabrafenib Durvalumab Trametinib 0 1
Dabrafenib + Encorafenib Dabrafenib Encorafenib 0 0
Dabrafenib + Everolimus + Trametinib Dabrafenib Everolimus Trametinib 1 0
Dabrafenib + Gefitinib Dabrafenib Gefitinib 0 0
Dabrafenib + GSK2126458 Dabrafenib GSK2126458 6 0
Dabrafenib + Hydroxychloroquine + Trametinib Dabrafenib Hydroxychloroquine Trametinib 0 1
Dabrafenib + Ipilimumab Dabrafenib Ipilimumab 0 2
Dabrafenib + Ipilimumab + Trametinib Dabrafenib Ipilimumab Trametinib 0 1
Dabrafenib + Itacitinib + Trametinib Dabrafenib Itacitinib Trametinib 0 1
Dabrafenib + KRT-232 + Trametinib Dabrafenib KRT-232 Trametinib 1 1
Dabrafenib + Lapatinib Dabrafenib Lapatinib 0 1
Dabrafenib + Larotrectinib + Trametinib Dabrafenib Larotrectinib Trametinib 0 0
Dabrafenib + Linsitinib Dabrafenib Linsitinib 0 0
Dabrafenib + LOXO-195 + Trametinib Dabrafenib LOXO-195 Trametinib 0 0
Dabrafenib + MCS110 + Trametinib Dabrafenib MCS110 Trametinib 0 1
Dabrafenib + Metformin + Trametinib Dabrafenib Metformin Trametinib 0 1
Dabrafenib + Midazolam + Rosuvastatin Dabrafenib Midazolam Rosuvastatin 0 1
Dabrafenib + Navitoclax + Trametinib Dabrafenib Navitoclax Trametinib 0 1
Dabrafenib + Nivolumab + Trametinib Dabrafenib Nivolumab Trametinib 0 1
Dabrafenib + Onalespib + Trametinib Dabrafenib Onalespib Trametinib 0 1
Dabrafenib + Osimertinib Dabrafenib Osimertinib 0 0
Dabrafenib + Panitumumab Dabrafenib Panitumumab 2 1
Dabrafenib + Panitumumab + Trametinib Dabrafenib Panitumumab Trametinib 2 1
Dabrafenib + Pazopanib Dabrafenib Pazopanib 0 1
Dabrafenib + Pembrolizumab Dabrafenib Pembrolizumab 0 1
Dabrafenib + Pembrolizumab + Trametinib Dabrafenib Pembrolizumab Trametinib 2 2
Dabrafenib + Phenformin + Trametinib Dabrafenib Phenformin Trametinib 0 1
Dabrafenib + Rabeprazole + Rifampin Dabrafenib Rabeprazole Rifampin 0 1
Dabrafenib + SCH772984 Dabrafenib SCH772984 2 0
Dabrafenib + SCH772984 + Trametinib Dabrafenib SCH772984 Trametinib 2 0
Dabrafenib + Selumetinib Dabrafenib Selumetinib 0 0
Dabrafenib + Spartalizumab + Trametinib Dabrafenib Spartalizumab Trametinib 0 3
Dabrafenib + Talimogene laherparepvec + Trametinib Dabrafenib Talimogene laherparepvec Trametinib 0 2
Dabrafenib + Trametinib Dabrafenib Trametinib 54 28
Dabrafenib + Trametinib + Uprosertib Dabrafenib Trametinib Uprosertib 0 0
Dabrafenib + Uprosertib Dabrafenib Uprosertib 0 1


Additional content available in CKB BOOST