Drug Detail

Drug Name Dabrafenib
Trade Name Tafinlar
Synonyms GSK2118436
Drug Descriptions

Tafinlar (dabrafenib) inhibits the activity of BRAF, including V600E, which results in inhibition of tumor cell proliferation (PMID: 22735384). Tafinlar (dabrafenib) is FDA approved for BRAF V600E positive unresectable or metastatic melanoma, and in combination with Mekinist (trametinib) for BRAF V600E/K-mutant melanoma, BRAF V600E-mutant non-small cell lung cancer, and BRAF V600E-mutant anaplastic thyroid cancer (FDA.gov).

DrugClasses BRAF Inhibitor 19

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Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + Dabrafenib + Trametinib 6MHP vaccine Dabrafenib Trametinib 0 1
Alpelisib + Dabrafenib + Erlotinib + Navitoclax Alpelisib Dabrafenib Erlotinib Navitoclax 1 0
Altiratinib + Dabrafenib Altiratinib Dabrafenib 0 0
AMG 232 + Dabrafenib + Trametinib AMG 232 Dabrafenib Trametinib 1 1
Cetuximab + Dabrafenib Cetuximab Dabrafenib 6 0
Cetuximab + Dabrafenib + SCH772984 Cetuximab Dabrafenib SCH772984 2 0
Cetuximab + Dabrafenib + Trametinib Cetuximab Dabrafenib Trametinib 8 0
CGM097 + Dabrafenib + Navitoclax + PF-04217903 CGM097 Dabrafenib Navitoclax PF-04217903 1 0
Dabrafenib Dabrafenib 48 15
Dabrafenib + Digoxin + Trametinib Dabrafenib Digoxin Trametinib 0 1
Dabrafenib + Durvalumab + Trametinib Dabrafenib Durvalumab Trametinib 0 1
Dabrafenib + Everolimus + Trametinib Dabrafenib Everolimus Trametinib 0 0
Dabrafenib + Gefitinib Dabrafenib Gefitinib 0 0
Dabrafenib + GSK2126458 Dabrafenib GSK2126458 6 0
Dabrafenib + Ipilimumab Dabrafenib Ipilimumab 0 2
Dabrafenib + Ipilimumab + Trametinib Dabrafenib Ipilimumab Trametinib 0 1
Dabrafenib + Itacitinib + Trametinib Dabrafenib Itacitinib Trametinib 0 1
Dabrafenib + Lapatinib Dabrafenib Lapatinib 0 1
Dabrafenib + MCS110 + Trametinib Dabrafenib MCS110 Trametinib 0 1
Dabrafenib + Metformin + Trametinib Dabrafenib Metformin Trametinib 0 1
Dabrafenib + Midazolam + Rosuvastatin Dabrafenib Midazolam Rosuvastatin 0 1
Dabrafenib + Navitoclax + Trametinib Dabrafenib Navitoclax Trametinib 0 1
Dabrafenib + Nivolumab + Trametinib Dabrafenib Nivolumab Trametinib 0 1
Dabrafenib + Onalespib + Trametinib Dabrafenib Onalespib Trametinib 0 1
Dabrafenib + Panitumumab Dabrafenib Panitumumab 2 1
Dabrafenib + Panitumumab + Trametinib Dabrafenib Panitumumab Trametinib 4 1
Dabrafenib + Pazopanib Dabrafenib Pazopanib 0 1
Dabrafenib + Pembrolizumab Dabrafenib Pembrolizumab 0 1
Dabrafenib + Pembrolizumab + Trametinib Dabrafenib Pembrolizumab Trametinib 0 2
Dabrafenib + Phenformin + Trametinib Dabrafenib Phenformin Trametinib 0 1
Dabrafenib + Rabeprazole + Rifampin Dabrafenib Rabeprazole Rifampin 0 1
Dabrafenib + SCH772984 Dabrafenib SCH772984 3 0
Dabrafenib + SCH772984 + Trametinib Dabrafenib SCH772984 Trametinib 2 0
Dabrafenib + Selumetinib Dabrafenib Selumetinib 0 0
Dabrafenib + Spartalizumab + Trametinib Dabrafenib Spartalizumab Trametinib 0 2
Dabrafenib + Talimogene laherparepvec + Trametinib Dabrafenib Talimogene laherparepvec Trametinib 0 2
Dabrafenib + Trametinib Dabrafenib Trametinib 46 25
Dabrafenib + Trametinib + Uprosertib Dabrafenib Trametinib Uprosertib 0 0
Dabrafenib + Uprosertib Dabrafenib Uprosertib 0 1