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Drug Name Dabrafenib
Trade Name Tafinlar
Synonyms GSK2118436
Drug Descriptions

Tafinlar (dabrafenib) inhibits the activity of BRAF, including V600E, which results in the inhibition of tumor cell proliferation (PMID: 22735384). Tafinlar (dabrafenib) is FDA approved for BRAF V600E/K- positive unresectable or metastatic melanoma, and in combination with Mekinist (trametinib) for BRAF V600E/K-mutant melanoma, BRAF V600E-mutant non-small cell lung cancer, BRAF V600E-mutant anaplastic thyroid cancer, for adult and pediatric patients of 6 years or older with unresectable or metastatic solid tumors harboring BRAF V600E, and for pediatric patients of 1 year or older with low-grade glioma harboring BRAF V600E (FDA.gov).

DrugClasses BRAF Inhibitor 25
CAS Registry Number 1195765-45-7
NCIT ID C82386

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Therapy Name Drugs Efficacy Evidence Clinical Trials
6MHP vaccine + Dabrafenib + Trametinib 6MHP vaccine Dabrafenib Trametinib 0 1
Afatinib + Dabrafenib Afatinib Dabrafenib 0 0
Alpelisib + Dabrafenib + Erlotinib + Navitoclax Alpelisib Dabrafenib Erlotinib Navitoclax 1 0
Altiratinib + Dabrafenib Altiratinib Dabrafenib 0 0
ARCC4 + Dabrafenib ARCC4 Dabrafenib 1 0
AZD3514 + Dabrafenib AZD3514 Dabrafenib 1 0
Capmatinib + Dabrafenib + Trametinib Capmatinib Dabrafenib Trametinib 0 0
Celecoxib + Dabrafenib + Panitumumab + Trametinib Celecoxib Dabrafenib Panitumumab Trametinib 1 0
Celecoxib + Dabrafenib + Trametinib Celecoxib Dabrafenib Trametinib 1 0
Cemiplimab + Dabrafenib + Trametinib Cemiplimab Dabrafenib Trametinib 0 1
Cetuximab + Dabrafenib Cetuximab Dabrafenib 2 0
Cetuximab + Dabrafenib + SCH772984 Cetuximab Dabrafenib SCH772984 2 0
Cetuximab + Dabrafenib + Trametinib Cetuximab Dabrafenib Trametinib 4 0
CGM097 + Dabrafenib + Navitoclax + PF-04217903 CGM097 Dabrafenib Navitoclax PF-04217903 1 0
Dabrafenib Dabrafenib 165 16
Dabrafenib + Digoxin + Trametinib Dabrafenib Digoxin Trametinib 0 1
Dabrafenib + DS03090629 DS03090629 Dabrafenib 2 0
Dabrafenib + Durvalumab + Trametinib Dabrafenib Durvalumab Trametinib 0 1
Dabrafenib + E6201 Dabrafenib E6201 0 2
Dabrafenib + Encorafenib Dabrafenib Encorafenib 0 0
Dabrafenib + Enzalutamide + Trametinib Dabrafenib Enzalutamide Trametinib 1 0
Dabrafenib + Everolimus + Trametinib Dabrafenib Everolimus Trametinib 1 0
Dabrafenib + Furmonertinib + Trametinib Dabrafenib Furmonertinib Trametinib 0 0
Dabrafenib + Gefitinib Dabrafenib Gefitinib 0 0
Dabrafenib + GSK2126458 Dabrafenib GSK2126458 6 0
Dabrafenib + Hydroxychloroquine + Trametinib Dabrafenib Hydroxychloroquine Trametinib 1 4
Dabrafenib + IAG933 Dabrafenib IAG933 1 0
Dabrafenib + IAG933 + LTT462 Dabrafenib IAG933 LTT462 1 0
Dabrafenib + IAG933 + Trametinib Dabrafenib IAG933 Trametinib 1 0
Dabrafenib + Ipilimumab Dabrafenib Ipilimumab 0 3
Dabrafenib + Ipilimumab + Nivolumab Dabrafenib Ipilimumab Nivolumab 0 1
Dabrafenib + Ipilimumab + Nivolumab + Trametinib Dabrafenib Ipilimumab Nivolumab Trametinib 0 1
Dabrafenib + Ipilimumab + Trametinib Dabrafenib Ipilimumab Trametinib 0 2
Dabrafenib + Itacitinib + Trametinib Dabrafenib Itacitinib Trametinib 0 1
Dabrafenib + JSI-1187 Dabrafenib JSI-1187 1 1
Dabrafenib + KRT-232 + Trametinib Dabrafenib KRT-232 Trametinib 2 1
Dabrafenib + Lapatinib Dabrafenib Lapatinib 0 1
Dabrafenib + Larotrectinib + Trametinib Dabrafenib Larotrectinib Trametinib 0 0
Dabrafenib + Lenvatinib Dabrafenib Lenvatinib 0 0
Dabrafenib + Lenvatinib + Trametinib Dabrafenib Lenvatinib Trametinib 0 0
Dabrafenib + Linsitinib Dabrafenib Linsitinib 0 0
Dabrafenib + LTT462 Dabrafenib LTT462 0 1
Dabrafenib + LTT462 + LXH 254 Dabrafenib LTT462 LXH 254 0 1
Dabrafenib + LTT462 + Spartalizumab Dabrafenib LTT462 Spartalizumab 0 1
Dabrafenib + LTT462 + TNO155 Dabrafenib LTT462 TNO155 0 1
Dabrafenib + LTT462 + Trametinib Dabrafenib LTT462 Trametinib 0 1
Dabrafenib + LXH 254 + Trametinib Dabrafenib LXH 254 Trametinib 2 0
Dabrafenib + MCS110 + Trametinib Dabrafenib MCS110 Trametinib 0 1
Dabrafenib + Metformin + Trametinib Dabrafenib Metformin Trametinib 0 1
Dabrafenib + Midazolam + Rosuvastatin Dabrafenib Midazolam Rosuvastatin 0 1
Dabrafenib + Navitoclax + Trametinib Dabrafenib Navitoclax Trametinib 0 1
Dabrafenib + Nilotinib + Trametinib Dabrafenib Nilotinib Trametinib 0 1
Dabrafenib + Nivolumab + Trametinib Dabrafenib Nivolumab Trametinib 1 1
Dabrafenib + Onalespib + Trametinib Dabrafenib Onalespib Trametinib 0 1
Dabrafenib + Osimertinib Dabrafenib Osimertinib 0 0
Dabrafenib + Osimertinib + Trametinib Dabrafenib Osimertinib Trametinib 0 0
Dabrafenib + Palbociclib + Trametinib Dabrafenib Palbociclib Trametinib 1 0
Dabrafenib + Panitumumab Dabrafenib Panitumumab 2 1
Dabrafenib + Panitumumab + Trametinib Dabrafenib Panitumumab Trametinib 2 1
Dabrafenib + Pazopanib Dabrafenib Pazopanib 0 1
Dabrafenib + Pembrolizumab Dabrafenib Pembrolizumab 0 1
Dabrafenib + Pembrolizumab + Trametinib Dabrafenib Pembrolizumab Trametinib 5 3
Dabrafenib + Phenformin + Trametinib Dabrafenib Phenformin Trametinib 0 1
Dabrafenib + Rabeprazole + Rifampin Dabrafenib Rabeprazole Rifampin 1 1
Dabrafenib + Rabeprazole + Rifampin + Trametinib Dabrafenib Rabeprazole Rifampin Trametinib 1 0
Dabrafenib + RAF709 + Trametinib Dabrafenib RAF709 Trametinib 2 0
Dabrafenib + Regorafenib + Trametinib Dabrafenib Regorafenib Trametinib 3 0
Dabrafenib + SCH772984 Dabrafenib SCH772984 3 0
Dabrafenib + SCH772984 + Trametinib Dabrafenib SCH772984 Trametinib 2 0
Dabrafenib + Selitrectinib + Trametinib Dabrafenib Selitrectinib Trametinib 0 0
Dabrafenib + Selumetinib Dabrafenib Selumetinib 0 0
Dabrafenib + Sintilimab + Trametinib Dabrafenib Sintilimab Trametinib 0 0
Dabrafenib + Spartalizumab Dabrafenib Spartalizumab 0 1
Dabrafenib + Spartalizumab + Trametinib Dabrafenib Spartalizumab Trametinib 2 3
Dabrafenib + Talazoparib Dabrafenib Talazoparib 1 0
Dabrafenib + Talazoparib + Trametinib Dabrafenib Talazoparib Trametinib 2 0
Dabrafenib + Talimogene laherparepvec + Trametinib Dabrafenib Talimogene laherparepvec Trametinib 0 2
Dabrafenib + Tazemetostat + Trametinib Dabrafenib Tazemetostat Trametinib 0 1
Dabrafenib + TNO155 + Trametinib Dabrafenib TNO155 Trametinib 0 1
Dabrafenib + Trametinib Dabrafenib Trametinib 170 38
Dabrafenib + Trametinib + Uprosertib Dabrafenib Trametinib Uprosertib 0 1
Dabrafenib + Uprosertib Dabrafenib Uprosertib 0 1


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