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Drug Name Regorafenib
Trade Name Stivarga
Synonyms BAY 73-4506
Drug Descriptions

Stivarga (regorafenib) is an inhibitor of several kinases including VEGFR, RET, KIT, PDGFR and RAF, thereby inhibiting tumor angiogenesis and tumor cell proliferation (PMID: 24756792). Stivarga (regorafenib) is FDA approved for colorectal cancer, hepatocellular carcinoma, and GIST (FDA.gov).

DrugClasses BRAF Inhibitor 20 CRAF Inhibitor 12 KIT Inhibitor 50 PDGFR Inhibitor (Pan) 27 RET Inhibitor 39 VEGFR Inhibitor (Pan) 32 VEGFR2 Inhibitor 35

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin + Regorafenib + Trastuzumab ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-021 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Oxaliplatin Regorafenib Trastuzumab haNK cells 0 1
Ascrinvacumab + Regorafenib Ascrinvacumab Regorafenib 0 1
Azacitidine + Regorafenib Azacitidine Regorafenib 0 1
Capecitabine + Regorafenib Capecitabine Regorafenib 0 1
Capecitabine + Regorafenib + Ruxolitinib Capecitabine Regorafenib Ruxolitinib 0 1
Cetuximab + Regorafenib Cetuximab Regorafenib 2 2
Clobetasol + Regorafenib Clobetasol Regorafenib 0 1
Crizotinib + Regorafenib Crizotinib Regorafenib 0 0
CVX-060 + Regorafenib CVX-060 Regorafenib 0 0
DHA + Regorafenib DHA Regorafenib 1 0
Entinostat + Hydroxychloroquine + Regorafenib Entinostat Hydroxychloroquine Regorafenib 0 1
Fluorouracil + Leucovorin + Oxaliplatin + Regorafenib Fluorouracil Leucovorin Oxaliplatin Regorafenib 0 1
Fluorouracil + Leucovorin + Regorafenib Fluorouracil Leucovorin Regorafenib 0 1
Gemcitabine + Regorafenib Gemcitabine Regorafenib 0 1
Ipilimumab + Nivolumab + Regorafenib Ipilimumab Nivolumab Regorafenib 0 1
Methotrexate + Regorafenib Methotrexate Regorafenib 0 1
MK2206 + Regorafenib + Sorafenib MK2206 Regorafenib Sorafenib 0 0
Napabucasin + Regorafenib Napabucasin Regorafenib 0 1
Nivolumab + Regorafenib Nivolumab Regorafenib 0 2
Panitumumab + Regorafenib Panitumumab Regorafenib 0 1
Pembrolizumab + Regorafenib Pembrolizumab Regorafenib 0 2
Perindopril + Regorafenib Perindopril Regorafenib 0 1
Pimasertib + Regorafenib Pimasertib Regorafenib 3 0
Refametinib + Regorafenib Refametinib Regorafenib 0 1
Regorafenib Regorafenib 61 49
Regorafenib + Sorafenib Regorafenib Sorafenib 0 0
Regorafenib + Spartalizumab Regorafenib Spartalizumab 0 1
Regorafenib + Sunitinib Regorafenib Sunitinib 0 0
Regorafenib + trifluridine/tipiracil hydrochloride Regorafenib trifluridine/tipiracil hydrochloride 0 1


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