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Drug Name Napabucasin
Trade Name
Synonyms BB608|BBI608|BBI-608
Drug Descriptions

Napabucasin (BBI608) is a small molecule inhibitor of cancer “stemness” that reduces activated Stat3 signaling, which is often activated by FGFRs, thereby decreasing proliferation of cancer stem cells, and possibly resulting in decreased cancer metastasis (PMID: 25605917, PMID: 23935373).

DrugClasses STAT3 Inhibitor 19

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Napabucasin Bevacizumab Fluorouracil Irinotecan Leucovorin Napabucasin 0 0
Bevacizumab + Napabucasin Bevacizumab Napabucasin 0 1
Capecitabine + Napabucasin Capecitabine Napabucasin 0 1
Cetuximab + Napabucasin Cetuximab Napabucasin 0 1
Fluorouracil + Irinotecan + Leucovorin + Napabucasin Fluorouracil Irinotecan Leucovorin Napabucasin 0 1
Gemcitabine + Nab-paclitaxel + Napabucasin Gemcitabine Nab-paclitaxel Napabucasin 0 3
Napabucasin Napabucasin 4 9
Napabucasin + Nivolumab Napabucasin Nivolumab 0 1
Napabucasin + Paclitaxel Napabucasin Paclitaxel 4 3
Napabucasin + Panitumumab Napabucasin Panitumumab 0 1
Napabucasin + Regorafenib Napabucasin Regorafenib 0 1
Napabucasin + Sorafenib Napabucasin Sorafenib 0 1


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