Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Napabucasin
Trade Name
Synonyms BB608|BBI608|BBI-608|GB201|GB-201|GB 201
Drug Descriptions

Napabucasin (BBI608) is a small molecule inhibitor of cancer stemness that reduces activated Stat3 signaling, which is often activated by FGFRs, thereby decreasing proliferation of cancer stem cells, and possibly resulting in decreased cancer metastasis (PMID: 25605917, PMID: 23935373, PMID: 32694160).

DrugClasses STAT3 Inhibitor 26
CAS Registry Number 83280-65-3
NCIT ID C96429


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Napabucasin Bevacizumab Fluorouracil Irinotecan Leucovorin Napabucasin 0 0
Bevacizumab + Napabucasin Bevacizumab Napabucasin 0 1
Capecitabine + Napabucasin Capecitabine Napabucasin 0 1
Cetuximab + Napabucasin Cetuximab Napabucasin 0 1
Fluorouracil + Irinotecan + Leucovorin + Napabucasin Fluorouracil Irinotecan Leucovorin Napabucasin 0 1
Gemcitabine + Nab-paclitaxel + Napabucasin Gemcitabine Nab-paclitaxel Napabucasin 0 3
Gemcitabine + Napabucasin + Paclitaxel Gemcitabine Napabucasin Paclitaxel 0 1
Napabucasin Napabucasin 1 9
Napabucasin + Nivolumab Napabucasin Nivolumab 0 1
Napabucasin + Paclitaxel Napabucasin Paclitaxel 0 3
Napabucasin + Panitumumab Napabucasin Panitumumab 0 1
Napabucasin + Pembrolizumab Napabucasin Pembrolizumab 0 0
Napabucasin + Regorafenib Napabucasin Regorafenib 0 1
Napabucasin + Sorafenib Napabucasin Sorafenib 0 1

Additional content available in CKB BOOST