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| Drug Name | Sorafenib |
| Trade Name | Nexavar |
| Synonyms | BAY 43-9006 |
| Drug Descriptions |
Nexavar (sorafenib) is a multikinase inhibitor with activity against several kinases, including RAF kinases, VEGFR2, VEGFR3, PDGFR-beta, KIT, FLT3, RET, and CSF1R, potentially resulting in decreased tumor growth (PMID: 18445656, PMID: 15466206, PMID: 21517818). Nexavar (sorafenib) is FDA approved for metastatic differentiated thyroid carcinoma, hepatocellular carcinoma, and renal cell carcinoma (FDA.gov). |
| DrugClasses | CSF1R Inhibitor 26 FLT3 Inhibitor 56 KIT Inhibitor 51 PDGFR-beta Inhibitor 13 RAF Inhibitor (Pan) 18 RET Inhibitor 40 VEGFR2 Inhibitor 35 |
| CAS Registry Number | 284461-73-0 |
| NCIT ID | C61948 |
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