Drug Detail

Drug Name Sorafenib
Trade Name Nexavar
Synonyms BAY 43-9006
Drug Descriptions

Nexavar (sorafenib) is a multikinase inhibitor with activity against several kinases, including RAF kinases, VEGFR2, VEGFR3, PDGFR-beta, KIT, FLT3, RET, and CSF1R, potentially resulting in decreased tumor growth (PMID: 18445656, PMID: 15466206, PMID: 21517818). Nexavar (sorafenib) is approved for metastatic differentiated thyroid carcinoma, hepatocellular carcinoma, and renal cell carcinoma (FDA.gov).

DrugClasses CSF1R Inhibitor 23 FLT3 Inhibitor 50 KIT Inhibitor 50 PDGFR-beta Inhibitor 13 RAF Inhibitor (Pan) 16 RET Inhibitor 36 VEGFR2 Inhibitor 34

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Sorafenib ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Sorafenib haNK cells 0 1
Alvocidib + Sorafenib Alvocidib Sorafenib 0 0
Azacitidine + Sorafenib Azacitidine Sorafenib 2 1
Bavituximab + Sorafenib Bavituximab Sorafenib 0 1
BBI503 + Sorafenib BBI503 Sorafenib 0 1
Bevacizumab + Cyclophosphamide + Doxorubicin + Etoposide + Ifosfamide + Irinotecan + Sorafenib + Temozolomide + Temsirolimus + Vincristine Bevacizumab Cyclophosphamide Doxorubicin Etoposide Ifosfamide Irinotecan Sorafenib Temozolomide Temsirolimus Vincristine 0 1
Bevacizumab + Cyclophosphamide + Sorafenib Bevacizumab Cyclophosphamide Sorafenib 0 2
Bevacizumab + Oxaliplatin + Sorafenib Bevacizumab Oxaliplatin Sorafenib 0 1
Bevacizumab + Sorafenib Bevacizumab Sorafenib 6 0
Bevacizumab + Sorafenib + Temsirolimus Bevacizumab Sorafenib Temsirolimus 0 0
BEZ235 + Sorafenib BEZ235 Sorafenib 1 0
Bortezomib + Decitabine + Sorafenib Bortezomib Decitabine Sorafenib 0 1
Bortezomib + Sorafenib + Vorinostat Bortezomib Sorafenib Vorinostat 0 1
Busulfan + Fludarabine + Sorafenib Busulfan Fludarabine Sorafenib 0 1
Capecitabine + Sorafenib Capecitabine Sorafenib 0 2
Carboplatin + Paclitaxel + Sorafenib Carboplatin Paclitaxel Sorafenib 1 0
Carotuximab + Sorafenib Carotuximab Sorafenib 0 2
CC-122 + Sorafenib CC-122 Sorafenib 0 1
Cetuximab + Sorafenib Cetuximab Sorafenib 1 0
Cisplatin + Docetaxel + Sorafenib Cisplatin Docetaxel Sorafenib 0 1
Cisplatin + Doxorubicin + Gemcitabine + Oxaliplatin + Sorafenib Cisplatin Doxorubicin Gemcitabine Oxaliplatin Sorafenib 0 1
Cisplatin + Doxorubicin + Sorafenib Cisplatin Doxorubicin Sorafenib 0 1
Cisplatin + Gemcitabine + Sorafenib Cisplatin Gemcitabine Sorafenib 3 0
Cisplatin + Paclitaxel + Sorafenib Cisplatin Paclitaxel Sorafenib 0 1
Cisplatin + Sorafenib + Tamoxifen Cisplatin Sorafenib Tamoxifen 0 1
Clofarabine + Cytarabine + Dexamethasone + Idarubicin + Sorafenib + Vincristine Clofarabine Cytarabine Dexamethasone Idarubicin Sorafenib Vincristine 0 1
Clofarabine + Cytarabine + Sorafenib Clofarabine Cytarabine Sorafenib 0 1
Crenolanib + Sorafenib Crenolanib Sorafenib 0 1
CVM-1118 + Sorafenib CVM-1118 Sorafenib 0 1
CVX-060 + Sorafenib CVX-060 Sorafenib 1 0
Cyclophosphamide + Sorafenib + Topotecan Cyclophosphamide Sorafenib Topotecan 0 1
Dalantercept + Sorafenib Dalantercept Sorafenib 0 1
Decitabine + Sorafenib Decitabine Sorafenib 1 0
Docetaxel + Sorafenib Docetaxel Sorafenib 0 1
Doxorubicin + Sorafenib Doxorubicin Sorafenib 0 1
Epirubicin + Ifosfamide + Sorafenib Epirubicin Ifosfamide Sorafenib 0 1
Erlotinib + Sorafenib Erlotinib Sorafenib 1 0
Everolimus + Sorafenib Everolimus Sorafenib 0 2
Evofosfamide + Sorafenib Evofosfamide Sorafenib 0 1
Fingolimod + Sorafenib Fingolimod Sorafenib 1 0
Fluorouracil + Quinacrine + Sorafenib Fluorouracil Quinacrine Sorafenib 1 0
Fluorouracil + Sorafenib Fluorouracil Sorafenib 2 0
Galunisertib + Sorafenib Galunisertib Sorafenib 0 1
Gemcitabine + Nab-paclitaxel + Sorafenib + Vorinostat Gemcitabine Nab-paclitaxel Sorafenib Vorinostat 0 1
Gemcitabine + Oxaliplatin + Sorafenib Gemcitabine Oxaliplatin Sorafenib 0 0
GMI-1359 + Sorafenib GMI-1359 Sorafenib 1 0
GW5074 + Sorafenib GW5074 Sorafenib 2 0
Hydroxychloroquine + Sorafenib Hydroxychloroquine Sorafenib 0 2
Ipafricept + Sorafenib Ipafricept Sorafenib 0 1
Irinotecan + Sorafenib Irinotecan Sorafenib 0 2
KD018 + Sorafenib KD018 Sorafenib 0 1
Lenalidomide + Sorafenib Lenalidomide Sorafenib 1 0
Lenvatinib + Sorafenib Lenvatinib Sorafenib 0 1
Metformin + Sorafenib Metformin Sorafenib 1 0
MK2206 + Regorafenib + Sorafenib MK2206 Regorafenib Sorafenib 0 0
Napabucasin + Sorafenib Napabucasin Sorafenib 0 1
Navitoclax + Sorafenib Navitoclax Sorafenib 0 1
Nivolumab + Sorafenib Nivolumab Sorafenib 0 1
Palbociclib + Sorafenib Palbociclib Sorafenib 0 1
Panobinostat + Sorafenib Panobinostat Sorafenib 0 1
Pembrolizumab + Sorafenib Pembrolizumab Sorafenib 0 1
Pemetrexed + Sorafenib Pemetrexed Sorafenib 4 2
Pictilisib + Sorafenib Pictilisib Sorafenib 0 0
Pimasertib + Sorafenib Pimasertib Sorafenib 4 0
PX-866 + Sorafenib PX-866 Sorafenib 1 0
Quinacrine + Sorafenib Quinacrine Sorafenib 0 0
Refametinib + Sorafenib Refametinib Sorafenib 6 1
Regorafenib + Sorafenib Regorafenib Sorafenib 0 0
Resminostat + Sorafenib Resminostat Sorafenib 1 0
Riluzole + Sorafenib Riluzole Sorafenib 0 1
Selinexor + Sorafenib Selinexor Sorafenib 4 1
Selumetinib + Sorafenib Selumetinib Sorafenib 1 0
SF1126 + Sorafenib SF1126 Sorafenib 1 0
Sorafenib Sorafenib 62 51
Sorafenib + Spartalizumab Sorafenib Spartalizumab 0 1
Sorafenib + Temsirolimus Sorafenib Temsirolimus 1 1
Sorafenib + Topotecan Sorafenib Topotecan 0 1
Sorafenib + Trametinib Sorafenib Trametinib 0 1
Sorafenib + Trebananib Sorafenib Trebananib 0 1
Sorafenib + Vemurafenib Sorafenib Vemurafenib 0 1
Sorafenib + Vinorelbine Sorafenib Vinorelbine 1 1
Sorafenib + Vorinostat Sorafenib Vorinostat 0 1