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Drug Name Sorafenib
Trade Name Nexavar
Synonyms BAY 43-9006
Drug Descriptions

Nexavar (sorafenib) is a multikinase inhibitor with activity against several kinases, including RAF kinases, VEGFR2, VEGFR3, PDGFR-beta, KIT, FLT3, RET, and CSF1R, potentially resulting in decreased tumor growth (PMID: 18445656, PMID: 15466206, PMID: 21517818). Nexavar (sorafenib) is FDA approved for metastatic differentiated thyroid carcinoma, hepatocellular carcinoma, and renal cell carcinoma (FDA.gov).

DrugClasses CSF1R Inhibitor 28 FLT3 Inhibitor 65 KIT Inhibitor 57 PDGFR-beta Inhibitor 14 RAF Inhibitor (Pan) 27 RET Inhibitor 52 VEGFR2 Inhibitor 37
CAS Registry Number 284461-73-0
NCIT ID C61948

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABX196 + Sorafenib ABX196 Sorafenib 0 0
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Sorafenib ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Sorafenib haNK cells 0 1
Alvocidib + Sorafenib Alvocidib Sorafenib 0 0
Amcasertib + Sorafenib Amcasertib Sorafenib 0 1
Asparaginase Erwinia chrysanthemi + Cytarabine + Sorafenib Asparaginase Erwinia chrysanthemi Cytarabine Sorafenib 0 1
Atezolizumab + Bevacizumab + Cyclophosphamide + Sorafenib Atezolizumab Bevacizumab Cyclophosphamide Sorafenib 0 1
Atezolizumab + Sorafenib Atezolizumab Sorafenib 0 1
Azacitidine + Sorafenib Azacitidine Sorafenib 3 1
Azacitidine + Sorafenib + Venetoclax Azacitidine Sorafenib Venetoclax 1 0
Bavituximab + Sorafenib Bavituximab Sorafenib 0 1
Bevacizumab + Cyclophosphamide + Doxorubicin + Etoposide + Ifosfamide + Irinotecan + Sorafenib + Temozolomide + Temsirolimus + Vincristine Sulfate Bevacizumab Cyclophosphamide Doxorubicin Etoposide Ifosfamide Irinotecan Sorafenib Temozolomide Temsirolimus Vincristine Sulfate 0 1
Bevacizumab + Cyclophosphamide + Sorafenib Bevacizumab Cyclophosphamide Sorafenib 0 2
Bevacizumab + Oxaliplatin + Sorafenib Bevacizumab Oxaliplatin Sorafenib 0 1
Bevacizumab + Sorafenib Bevacizumab Sorafenib 1 0
Bevacizumab + Sorafenib + Temsirolimus Bevacizumab Sorafenib Temsirolimus 0 0
Bortezomib + Decitabine + Sorafenib Bortezomib Decitabine Sorafenib 0 1
Bortezomib + Sorafenib + Vorinostat Bortezomib Sorafenib Vorinostat 0 1
Busulfan + Fludarabine + Sorafenib Busulfan Fludarabine Sorafenib 0 1
C6-ceramide nanoliposome + Sorafenib C6-ceramide nanoliposome Sorafenib 1 0
Capecitabine + Sorafenib Capecitabine Sorafenib 0 2
Carboplatin + Paclitaxel + Sorafenib Carboplatin Paclitaxel Sorafenib 0 0
Carotuximab + Sorafenib Carotuximab Sorafenib 0 2
CC-122 + Sorafenib CC-122 Sorafenib 0 1
CEBPA-51 + Sorafenib CEBPA-51 Sorafenib 0 1
Cetuximab + Sorafenib Cetuximab Sorafenib 1 0
Cisplatin + Docetaxel + Sorafenib Cisplatin Docetaxel Sorafenib 0 1
Cisplatin + Doxorubicin + Gemcitabine + Oxaliplatin + Sorafenib Cisplatin Doxorubicin Gemcitabine Oxaliplatin Sorafenib 0 2
Cisplatin + Doxorubicin + Sorafenib Cisplatin Doxorubicin Sorafenib 0 2
Cisplatin + Gemcitabine + Sorafenib Cisplatin Gemcitabine Sorafenib 1 0
Cisplatin + Paclitaxel + Sorafenib Cisplatin Paclitaxel Sorafenib 0 1
Cisplatin + Sorafenib + Tamoxifen Cisplatin Sorafenib Tamoxifen 0 1
Clofarabine + Cytarabine + Dexamethasone + Idarubicin + Sorafenib + Vincristine Sulfate Clofarabine Cytarabine Dexamethasone Idarubicin Sorafenib Vincristine Sulfate 0 1
Clofarabine + Cytarabine + Sorafenib Clofarabine Cytarabine Sorafenib 0 1
Crenolanib + Sorafenib Crenolanib Sorafenib 7 1
CVM-1118 + Sorafenib CVM-1118 Sorafenib 0 1
CVX-060 + Sorafenib CVX-060 Sorafenib 0 0
Cyclophosphamide + Sorafenib + Topotecan Cyclophosphamide Sorafenib Topotecan 0 1
Cytarabine + Daunorubicin + Etoposide + Gemtuzumab ozogamicin + Sorafenib Cytarabine Daunorubicin Etoposide Gemtuzumab ozogamicin Sorafenib 0 1
Cytarabine + Daunorubicin + Etoposide + Sorafenib Cytarabine Daunorubicin Etoposide Sorafenib 0 0
Cytarabine + Etoposide + Sorafenib Cytarabine Etoposide Sorafenib 0 1
Cytarabine + Mitoxantrone + Sorafenib Cytarabine Mitoxantrone Sorafenib 1 1
Dactolisib + Sorafenib Dactolisib Sorafenib 1 0
Dalantercept + Sorafenib Dalantercept Sorafenib 0 1
Decitabine + Sorafenib Decitabine Sorafenib 2 0
Denosumab + Sorafenib Denosumab Sorafenib 1 0
DKN-01 + Sorafenib DKN-01 Sorafenib 0 0
Docetaxel + Sorafenib Docetaxel Sorafenib 0 1
Doxorubicin + Sorafenib Doxorubicin Sorafenib 0 1
Epirubicin + Ifosfamide + Sorafenib Epirubicin Ifosfamide Sorafenib 0 1
Erlotinib + Sorafenib Erlotinib Sorafenib 0 0
Everolimus + Sorafenib Everolimus Sorafenib 1 2
Evofosfamide + Sorafenib Evofosfamide Sorafenib 0 1
Fingolimod + Sorafenib Fingolimod Sorafenib 0 0
Fluorouracil + Quinacrine + Sorafenib Fluorouracil Quinacrine Sorafenib 0 0
Fluorouracil + Sorafenib Fluorouracil Sorafenib 0 0
Galunisertib + Sorafenib Galunisertib Sorafenib 0 1
Gemcitabine + Nab-paclitaxel + Sorafenib + Vorinostat Gemcitabine Nab-paclitaxel Sorafenib Vorinostat 0 1
Gemcitabine + Oxaliplatin + Sorafenib Gemcitabine Oxaliplatin Sorafenib 0 1
GLYCAR T cells + Sorafenib GLYCAR T cells Sorafenib 0 0
GMI-1359 + Sorafenib GMI-1359 Sorafenib 1 0
GW5074 + Sorafenib GW5074 Sorafenib 0 0
Hydroxychloroquine + Sorafenib Hydroxychloroquine Sorafenib 0 2
Intuvax + Sorafenib Intuvax Sorafenib 0 0
Ipafricept + Sorafenib Ipafricept Sorafenib 0 1
Irinotecan + Sorafenib Irinotecan Sorafenib 0 2
JX-594 + Sorafenib JX-594 Sorafenib 0 0
LAM-003 + Sorafenib LAM-003 Sorafenib 0 0
Lenalidomide + Sorafenib Lenalidomide Sorafenib 0 0
Lenvatinib + Sorafenib Lenvatinib Sorafenib 0 2
Metformin + Sorafenib Metformin Sorafenib 0 0
MI-503 + Sorafenib MI-503 Sorafenib 0 0
MK2206 + Regorafenib + Sorafenib MK2206 Regorafenib Sorafenib 0 0
Napabucasin + Sorafenib Napabucasin Sorafenib 0 1
Navitoclax + Sorafenib Navitoclax Sorafenib 0 1
Nivolumab + Sorafenib Nivolumab Sorafenib 0 1
Palbociclib + Sorafenib Palbociclib Sorafenib 0 1
Panobinostat + Sorafenib Panobinostat Sorafenib 0 1
PD-0325901 + Sorafenib PD-0325901 Sorafenib 2 0
Pembrolizumab + Sorafenib Pembrolizumab Sorafenib 0 1
Pemetrexed Disodium + Sorafenib Pemetrexed Disodium Sorafenib 1 2
Pictilisib + Sorafenib Pictilisib Sorafenib 1 0
Pimasertib + Sorafenib Pimasertib Sorafenib 3 0
PRT062607 + Sorafenib PRT062607 Sorafenib 2 0
PX-866 + Sorafenib PX-866 Sorafenib 0 0
Quinacrine + Sorafenib Quinacrine Sorafenib 0 0
Refametinib + Sorafenib Refametinib Sorafenib 1 1
Regorafenib + Sorafenib Regorafenib Sorafenib 0 0
Resminostat + Sorafenib Resminostat Sorafenib 0 0
Riluzole + Sorafenib Riluzole Sorafenib 0 1
Ruxolitinib + Sorafenib Ruxolitinib Sorafenib 1 0
Saridegib + Sorafenib Saridegib Sorafenib 1 0
Selinexor + Sorafenib Selinexor Sorafenib 4 1
Selumetinib + Sorafenib Selumetinib Sorafenib 0 0
SF1126 + Sorafenib SF1126 Sorafenib 0 0
SLMP53-2 + Sorafenib SLMP53-2 Sorafenib 1 0
Sonidegib + Sorafenib Sonidegib Sorafenib 1 0
Sorafenib Sorafenib 119 53
Sorafenib + Spartalizumab Sorafenib Spartalizumab 0 1
Sorafenib + Sunitinib Sorafenib Sunitinib 1 0
Sorafenib + Temsirolimus Sorafenib Temsirolimus 0 1
Sorafenib + Topotecan Sorafenib Topotecan 0 1
Sorafenib + Trametinib Sorafenib Trametinib 4 1
Sorafenib + Trebananib Sorafenib Trebananib 0 1
Sorafenib + Vemurafenib Sorafenib Vemurafenib 0 2
Sorafenib + Vinorelbine Sorafenib Vinorelbine 0 1
Sorafenib + Vorinostat Sorafenib Vorinostat 0 1
Sorafenib + YIV-906 Sorafenib YIV-906 0 1


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