Drug Detail


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Drug Name Saridegib
Trade Name
Synonyms IPI-926|IPI926|Patidegib
Drug Descriptions

Saridegib (IPI-926) is a Smoothened (SMO) antagonist that inhibits downstream signaling, potentially resulting in decreased growth of tumors with dysregulation of Hedgehog pathway signaling (PMID: 19522463,PMID: 26390428, PMID: 24608250).

DrugClasses SMO Inhibitor 16
CAS Registry Number 1037210-93-7
NCIT ID C80063


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Fluorouracil + Irinotecan + Leucovorin + Oxaliplatin + Saridegib Fluorouracil Irinotecan Leucovorin Oxaliplatin Saridegib 0 1
Saridegib Saridegib 0 0
Saridegib + Sorafenib Saridegib Sorafenib 1 0

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