Drug Detail


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Drug Name Sonidegib
Trade Name Odomzo
Synonyms NVP-LDE225|Erismodedgib|LDE-225
Drug Descriptions

Odomzo (sonidegib) is a small molecule inhibitor of SMO, which inhibits proliferation (PMID: 23935925). Odomzo (sonidegib) is FDA approved for use in patients with locally advanced basal cell carcinoma (FDA.gov).

DrugClasses SMO Inhibitor 16
CAS Registry Number 956697-53-3
NCIT ID C82385


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Sonidegib Bortezomib Sonidegib 0 1
Buparlisib + Sonidegib Buparlisib Sonidegib 0 2
Cisplatin + Etoposide + Sonidegib Cisplatin Etoposide Sonidegib 0 1
Cisplatin + Lomustine + Sonidegib + Vincristine Sulfate Cisplatin Lomustine Sonidegib Vincristine Sulfate 0 1
Everolimus + Sonidegib Everolimus Sonidegib 0 1
Gefitinib + Sonidegib Gefitinib Sonidegib 0 0
Gemcitabine + Nab-paclitaxel + Sonidegib Gemcitabine Nab-paclitaxel Sonidegib 0 1
Imiquimod + Sonidegib Imiquimod Sonidegib 0 1
Irinotecan + Sonidegib + Sorafenib Irinotecan Sonidegib Sorafenib 0 1
Lenalidomide + Sonidegib Lenalidomide Sonidegib 0 1
Paclitaxel + Sonidegib Paclitaxel Sonidegib 0 1
Pembrolizumab + Sonidegib Pembrolizumab Sonidegib 0 1
PHA-665752 + Sonidegib PHA-665752 Sonidegib 0 0
Ribociclib + Sonidegib Ribociclib Sonidegib 0 1
Sonidegib Sonidegib 0 10
Sonidegib + Sorafenib Sonidegib Sorafenib 1 0

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