Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Sonidegib
Trade Name Odomzo
Synonyms NVP-LDE225|Erismodedgib|LDE-225
Drug Descriptions

Odomzo (sonidegib) is a small molecule inhibitor of SMO, which inhibits proliferation (PMID: 23935925). Odomzo (sonidegib) is FDA approved for use in patients with locally advanced basal cell carcinoma (FDA.gov).

DrugClasses SMO Inhibitor 16
CAS Registry Number 956697-53-3
NCIT ID C82385


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Sonidegib Bortezomib Sonidegib 0 1
Buparlisib + Sonidegib Buparlisib Sonidegib 0 2
Cisplatin + Etoposide + Sonidegib Cisplatin Etoposide Sonidegib 0 1
Cisplatin + Lomustine + Sonidegib + Vincristine Sulfate Cisplatin Lomustine Sonidegib Vincristine Sulfate 0 0
Everolimus + Sonidegib Everolimus Sonidegib 0 1
Gefitinib + Sonidegib Gefitinib Sonidegib 0 0
Gemcitabine + Nab-paclitaxel + Sonidegib Gemcitabine Nab-paclitaxel Sonidegib 0 1
Imiquimod + Sonidegib Imiquimod Sonidegib 0 1
Lenalidomide + Sonidegib Lenalidomide Sonidegib 0 1
Paclitaxel + Sonidegib Paclitaxel Sonidegib 0 1
Pembrolizumab + Sonidegib Pembrolizumab Sonidegib 0 1
PHA-665752 + Sonidegib PHA-665752 Sonidegib 0 0
Ribociclib + Sonidegib Ribociclib Sonidegib 0 1
Sonidegib Sonidegib 0 10
Sonidegib + Sorafenib Sonidegib Sorafenib 1 0

Additional content available in CKB BOOST