Drug Detail

Drug Name Gefitinib
Trade Name Iressa
Synonyms ZD1839
Drug Descriptions

Iressa (gefitinib) is a first-generation EGFR inhibitor that binds EGFR and inhibits downstream signaling, potentially resulting in decreased growth of tumors with EGFR activation (PMID: 26980062, PMID: 25302162, PMID: 15284455). Iressa (gefitinib) is FDA approved for use in patients with non-small cell lung cancer harboring an EGFR exon 19 deletion or EGFR L858R (FDA.gov).

DrugClasses EGFR Inhibitor (Pan) 43 EGFR Inhibitor 1st gen 3

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AC-93253 iodide + Gefitinib AC-93253 iodide Gefitinib 1 0
AZD4547 + Gefitinib AZD4547 Gefitinib 0 0
Cabozantinib + Gefitinib Cabozantinib Gefitinib 0 0
Capmatinib + Gefitinib Capmatinib Gefitinib 0 0
Cediranib + Gefitinib Cediranib Gefitinib 2 0
Crizotinib + Gefitinib Crizotinib Gefitinib 1 0
Dabrafenib + Gefitinib Dabrafenib Gefitinib 0 0
Dasatinib + Gefitinib Dasatinib Gefitinib 0 0
Decitabine + Gefitinib Decitabine Gefitinib 0 0
Durvalumab + Gefitinib Durvalumab Gefitinib 0 1
Erlotinib + Gefitinib Erlotinib Gefitinib 0 1
Ficlatuzumab + Gefitinib Ficlatuzumab Gefitinib 1 0
Gefitinib Gefitinib 23 5
Gefitinib + Golvatinib Gefitinib Golvatinib 0 0
Gefitinib + Imatinib Gefitinib Imatinib 0 0
Gefitinib + IPA-3 Gefitinib IPA-3 0 0
Gefitinib + K-756 Gefitinib K-756 0 0
Gefitinib + Linsitinib Gefitinib Linsitinib 0 0
Gefitinib + Linsitinib + PHA-665752 Gefitinib Linsitinib PHA-665752 0 0
Gefitinib + LY294002 Gefitinib LY294002 0 0
Gefitinib + MEDI5117 Gefitinib MEDI5117 0 0
Gefitinib + Nazartinib Gefitinib Nazartinib 0 2
Gefitinib + NPS-1034 Gefitinib NPS-1034 0 0
Gefitinib + Obatoclax Gefitinib Obatoclax 0 0
Gefitinib + Osimertinib Gefitinib Osimertinib 0 2
Gefitinib + Pembrolizumab Gefitinib Pembrolizumab 0 1
Gefitinib + Pemetrexed Gefitinib Pemetrexed 0 0
Gefitinib + Perifosine Gefitinib Perifosine 0 0
Gefitinib + PF-431396 Gefitinib PF-431396 0 0
Gefitinib + PF-573228 Gefitinib PF-573228 0 0
Gefitinib + PHA-665752 Gefitinib PHA-665752 0 0
Gefitinib + Pictilisib Gefitinib Pictilisib 0 0
Gefitinib + PLX4720 Gefitinib PLX4720 1 0
Gefitinib + Ramucirumab Gefitinib Ramucirumab 0 1
Gefitinib + Savolitinib Gefitinib Savolitinib 0 0
Gefitinib + Sonidegib Gefitinib Sonidegib 0 0
Gefitinib + TAK-701 Gefitinib TAK-701 0 0
Gefitinib + Talniflumate Gefitinib Talniflumate 0 0
Gefitinib + Trametinib Gefitinib Trametinib 1 0
Gefitinib + Vemurafenib Gefitinib Vemurafenib 1 0
Gefitinib + WZ4002 Gefitinib WZ4002 0 0