Drug Detail


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Drug Name Depatuxizumab mafodotin
Trade Name
Synonyms ABT-414|depatux-m
Drug Descriptions

Depatuxizumab mafodotin (ABT-414) is an antibody-drug conjugate comprising an EGFR-targeted antibody linked to an anti-microtubule drug, which delivers the cytotoxic agent to EGFR-expressing cells, potentially resulting in increased tumor cell death and decreased growth of EGFR-overexpressing tumors (PMID: 26846818, PMID: 29075855, PMID: 31747009, PMID: 32371586).

DrugClasses EGFR Antibody 57
CAS Registry Number 1585973-65-4
NCIT ID C105612


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABBV-321 + Depatuxizumab mafodotin ABBV-321 Depatuxizumab mafodotin 0 0
Depatuxizumab mafodotin Depatuxizumab mafodotin 0 3
Depatuxizumab mafodotin + Gefitinib Depatuxizumab mafodotin Gefitinib 0 0
Depatuxizumab mafodotin + Radiotherapy + Temozolomide Depatuxizumab mafodotin Radiotherapy Temozolomide 0 0
Depatuxizumab mafodotin + Temozolomide Depatuxizumab mafodotin Temozolomide 0 1

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