Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Perifosine
Trade Name
Synonyms KRX-0401|NSC-639966
Drug Descriptions

Perifosine (KRX-0401) is a synthetic alkylphospholipid that inhibits AKT resulting in apoptotic induction and antitumor activity (PMID: 16418332, PMID: 28864978, PMID: 31325145).

DrugClasses Akt Inhibitor (Pan) 21
CAS Registry Number 157716-52-4


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
ABT-737 + Perifosine ABT-737 Perifosine 0 0
Cisplatin + Perifosine Cisplatin Perifosine 0 0
Gefitinib + Perifosine Gefitinib Perifosine 0 0
Lapatinib + Perifosine Lapatinib Perifosine 0 0
Perifosine Perifosine 3 1
Perifosine + Temsirolimus Perifosine Temsirolimus 0 1

Additional content available in CKB BOOST