Therapy Detail

Therapy Name Cisplatin + Perifosine
Therapy Description


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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cisplatin Platinol CDDP Chemotherapy - Platinum 6 Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary).
Perifosine KRX-0401 Akt Inhibitor (Pan) 17 Perifosine is a synthetic alkylphospholipid that inhibits AKT resulting in apoptotic induction and antitumor activity (PMID: 16418332).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AKT1 positive ovarian clear cell carcinoma predicted - sensitive Cisplatin + Perifosine Preclinical - Cell culture Actionable In a preclinical study, Perifosine (KRX-0401) enhanced the sensitivity of human ovarian clear cell cancer cells with activated Akt1 to Platinol (cisplatin) treatment in culture (PMID: 25519148). 25519148
Clinical Trial Phase Therapies Title Recruitment Status