Drug Detail

Drug Name Temsirolimus
Trade Name Torisel
Synonyms CCI-779
Drug Descriptions

Torisel (temsirolimus) binds to FKBP-12 and allosterically inhibits mTOR (PMID: 16883305). Torisel (temsirolimus) is FDA approved for advanced renal cell carcinoma (FDA.gov).

DrugClasses mTORC1 Inhibitor 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Cetuximab + Temsirolimus Bevacizumab Cetuximab Temsirolimus 0 0
Bevacizumab + Cetuximab + Temsirolimus + Valproic acid Bevacizumab Cetuximab Temsirolimus Valproic acid 0 1
Bevacizumab + Cyclophosphamide + Doxorubicin + Etoposide + Ifosfamide + Irinotecan + Sorafenib + Temozolomide + Temsirolimus + Vincristine Bevacizumab Cyclophosphamide Doxorubicin Etoposide Ifosfamide Irinotecan Sorafenib Temozolomide Temsirolimus Vincristine 0 1
Bevacizumab + Doxorubicin + Temsirolimus Bevacizumab Doxorubicin Temsirolimus 1 1
Bevacizumab + Pegylated liposomal-doxorubicin + Temsirolimus Bevacizumab Pegylated liposomal-doxorubicin Temsirolimus 3 1
Bevacizumab + Sorafenib + Temsirolimus Bevacizumab Sorafenib Temsirolimus 0 0
Bevacizumab + Temsirolimus Bevacizumab Temsirolimus 3 0
Bortezomib + Temsirolimus + Topotecan Bortezomib Temsirolimus Topotecan 1 0
Carboplatin + Paclitaxel + Temsirolimus Carboplatin Paclitaxel Temsirolimus 4 0
Cetuximab + Temsirolimus Cetuximab Temsirolimus 2 0
Cyclophosphamide + Dasatinib + Temsirolimus Cyclophosphamide Dasatinib Temsirolimus 0 1
Denileukin diftitox + Temsirolimus Denileukin diftitox Temsirolimus 1 0
Erlotinib + Temsirolimus Erlotinib Temsirolimus 1 0
H3B-5942 + Temsirolimus H3B-5942 Temsirolimus 0 0
Hydroxychloroquine + Temsirolimus Hydroxychloroquine Temsirolimus 0 1
Ipatasertib + Temsirolimus Ipatasertib Temsirolimus 0 0
Irinotecan + Temsirolimus + Vincristine Irinotecan Temsirolimus Vincristine 0 1
Ixabepilone + Temsirolimus Ixabepilone Temsirolimus 0 1
Lenalidomide + Temsirolimus Lenalidomide Temsirolimus 0 1
Metformin + Temsirolimus Metformin Temsirolimus 1 1
MK2206 + Temsirolimus MK2206 Temsirolimus 2 0
Neratinib + Temsirolimus Neratinib Temsirolimus 2 1
Pegylated liposomal-doxorubicin + Temsirolimus Pegylated liposomal-doxorubicin Temsirolimus 1 0
Perifosine + Temsirolimus Perifosine Temsirolimus 0 1
Radiotherapy + Temsirolimus Radiotherapy Temsirolimus 1 0
Ruxolitinib + Temsirolimus Ruxolitinib Temsirolimus 1 0
SCH772984 + Temsirolimus SCH772984 Temsirolimus 0 0
Sorafenib + Temsirolimus Sorafenib Temsirolimus 1 1
Temsirolimus Temsirolimus 13 20
Temsirolimus + Tivantinib Temsirolimus Tivantinib 0 1
Temsirolimus + Vemurafenib Temsirolimus Vemurafenib 0 1
Temsirolimus + Vinblastine Temsirolimus Vinblastine 0 1
Temsirolimus + Vorinostat Temsirolimus Vorinostat 0 1


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