Drug Detail

Drug Name Hydroxychloroquine
Trade Name Plaquenil
Synonyms HCQ
Drug Descriptions

Plaquenil (hydroxychloroquine sulfate) increases intralysosomal pH, resulting in inhibition of autophagic protein degradation and accumulation of autophagosomes, which potentially leads to cell death in autophagy-dependent tumor cells (NCI Drug Dictionary).

DrugClasses

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Gemcitabine + Hydroxychloroquine + Nab-paclitaxel Avelumab Gemcitabine Hydroxychloroquine Nab-paclitaxel 0 1
Bevacizumab + Carboplatin + Hydroxychloroquine + Paclitaxel Bevacizumab Carboplatin Hydroxychloroquine Paclitaxel 0 1
Carboplatin + Hydroxychloroquine + Paclitaxel Carboplatin Hydroxychloroquine Paclitaxel 0 1
CPI-613 + Hydroxychloroquine CPI-613 Hydroxychloroquine 0 1
Cyclophosphamide + Dexamethasone + Hydroxychloroquine + Sirolimus Cyclophosphamide Dexamethasone Hydroxychloroquine Sirolimus 0 1
Entinostat + Hydroxychloroquine + Regorafenib Entinostat Hydroxychloroquine Regorafenib 0 1
Everolimus + Hydroxychloroquine Everolimus Hydroxychloroquine 1 2
Gedatolisib + Hydroxychloroquine Gedatolisib Hydroxychloroquine 0 1
Gemcitabine + Hydroxychloroquine + Nab-paclitaxel Gemcitabine Hydroxychloroquine Nab-paclitaxel 0 1
Hydroxychloroquine Hydroxychloroquine 0 8
Hydroxychloroquine + Itraconazole Hydroxychloroquine Itraconazole 0 1
Hydroxychloroquine + Letrozole + Palbociclib Hydroxychloroquine Letrozole Palbociclib 0 1
Hydroxychloroquine + MK2206 Hydroxychloroquine MK2206 0 1
Hydroxychloroquine + Sirolimus Hydroxychloroquine Sirolimus 0 1
Hydroxychloroquine + Sorafenib Hydroxychloroquine Sorafenib 0 2
Hydroxychloroquine + Temsirolimus Hydroxychloroquine Temsirolimus 0 1
Hydroxychloroquine + Trametinib Hydroxychloroquine Trametinib 0 1
Hydroxychloroquine + Vemurafenib Hydroxychloroquine Vemurafenib 0 1
Hydroxychloroquine + Vorinostat Hydroxychloroquine Vorinostat 0 2