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Drug Name MK2206
Trade Name
Synonyms MK-2206
Drug Descriptions

MK2206 binds to and inhibits the activity of AKT in a non-ATP competitive manner, which may result in the inhibition of the PI3K/AKT signaling pathway and tumor cell proliferation (PMID: 20571069).

DrugClasses Akt Inhibitor (Pan) 18

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABT-737 + MK2206 + Trametinib ABT-737 MK2206 Trametinib 1 0
Anastrozole + MK2206 Anastrozole MK2206 0 0
AZD8055 + MK2206 AZD8055 MK2206 1 0
Bendamustine + MK2206 + Rituximab Bendamustine MK2206 Rituximab 1 0
Dinaciclib + MK2206 Dinaciclib MK2206 0 1
DZNeP + MK2206 DZNeP MK2206 0 0
Erlotinib + MK2206 Erlotinib MK2206 0 1
Fulvestrant + MK2206 Fulvestrant MK2206 0 0
Fulvestrant + MK2206 + Ribociclib Fulvestrant MK2206 Ribociclib 0 0
Goserelin + MK2206 Goserelin MK2206 0 1
GSK343 + MK2206 GSK343 MK2206 0 0
Hydroxychloroquine + MK2206 Hydroxychloroquine MK2206 0 1
Idelalisib + MK2206 Idelalisib MK2206 0 0
Imatinib + MK2206 Imatinib MK2206 4 0
KRIBB11 + MK2206 KRIBB11 MK2206 1 0
LAM-003 + MK2206 LAM-003 MK2206 0 0
Lapatinib + MK2206 Lapatinib MK2206 2 0
MK2206 MK2206 25 2
MK2206 + Paclitaxel MK2206 Paclitaxel 1 0
MK2206 + Palbociclib MK2206 Palbociclib 1 0
MK2206 + Regorafenib + Sorafenib MK2206 Regorafenib Sorafenib 0 0
MK2206 + Ribociclib MK2206 Ribociclib 0 0
MK2206 + Ridaforolimus MK2206 Ridaforolimus 1 0
MK2206 + Romidepsin MK2206 Romidepsin 0 0
MK2206 + SCH772984 MK2206 SCH772984 0 0
MK2206 + Selumetinib MK2206 Selumetinib 1 1
MK2206 + Tazemetostat MK2206 Tazemetostat 1 0
MK2206 + Temsirolimus MK2206 Temsirolimus 2 0
MK2206 + Trametinib MK2206 Trametinib 1 0
MK2206 + Trastuzumab MK2206 Trastuzumab 1 1
MK2206 + Vemurafenib MK2206 Vemurafenib 1 0
MK2206 + Venetoclax MK2206 Venetoclax 1 0


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