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Drug Name | Dinaciclib |
Trade Name | |
Synonyms | SCH727965|MK-7965|SCH-727965 |
Drug Descriptions |
Dinaciclib (SCH 727965) inhibits cyclin dependent kinases CDK1, CDK2, CDK5, CDK9, and CDK12, which prevents phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 24900195, PMID: 24004674, PMID: 27880910, PMID: 32269732). |
DrugClasses | CDK1 Inhibitor 13 CDK2 Inhibitor 27 CDK5 Inhibitor 8 CDK9 Inhibitor 20 |
CAS Registry Number | 779353-01-4 |
NCIT ID | C78854 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Bortezomib + Dexamethasone + Dinaciclib | Bortezomib Dexamethasone Dinaciclib | 0 | 1 |
Carboplatin + Dinaciclib + Veliparib | Carboplatin Dinaciclib Veliparib | 0 | 0 |
Dinaciclib | Dinaciclib | 1 | 0 |
Dinaciclib + Doxorubicin | Dinaciclib Doxorubicin | 0 | 0 |
Dinaciclib + MK2206 | Dinaciclib MK2206 | 0 | 1 |
Dinaciclib + Olaparib | Dinaciclib Olaparib | 0 | 0 |
Dinaciclib + Paclitaxel | Dinaciclib Paclitaxel | 0 | 0 |
Dinaciclib + Pembrolizumab | Dinaciclib Pembrolizumab | 0 | 2 |
Dinaciclib + Veliparib | Dinaciclib Veliparib | 0 | 1 |
Dinaciclib + Venetoclax | Dinaciclib Venetoclax | 0 | 1 |