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Drug Name Dinaciclib
Trade Name
Synonyms SCH727965|MK-7965|SCH-727965
Drug Descriptions

Dinaciclib (SCH 727965) inhibits cyclin dependent kinases CDK1, CDK2, CDK5, CDK9, and CDK12, which prevents phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 24900195, PMID: 24004674, PMID: 27880910, PMID: 32269732).

DrugClasses CDK1 Inhibitor 13 CDK2 Inhibitor 30 CDK5 Inhibitor 8 CDK9 Inhibitor 21
CAS Registry Number 779353-01-4
NCIT ID C78854


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Dexamethasone + Dinaciclib Bortezomib Dexamethasone Dinaciclib 0 1
Carboplatin + Dinaciclib + Veliparib Carboplatin Dinaciclib Veliparib 0 0
Dinaciclib Dinaciclib 1 0
Dinaciclib + Doxorubicin Dinaciclib Doxorubicin 0 0
Dinaciclib + MK2206 Dinaciclib MK2206 0 1
Dinaciclib + Olaparib Dinaciclib Olaparib 0 0
Dinaciclib + Paclitaxel Dinaciclib Paclitaxel 0 0
Dinaciclib + Pembrolizumab Dinaciclib Pembrolizumab 0 2
Dinaciclib + PLX51107 Dinaciclib PLX51107 0 0
Dinaciclib + unspecified PD-1 antibody Dinaciclib unspecified PD-1 antibody 0 0
Dinaciclib + Veliparib Dinaciclib Veliparib 0 1
Dinaciclib + Venetoclax Dinaciclib Venetoclax 0 1

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