Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Dinaciclib
Trade Name
Synonyms SCH727965|MK-7965|SCH-727965
Drug Descriptions

Dinaciclib (SCH 727965) inhibits cyclin dependent kinases CDK1, CDK2, CDK5, CDK9, and CDK12, which prevents phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 24900195, PMID: 24004674, PMID: 27880910, PMID: 32269732).

DrugClasses CDK1 Inhibitor 13 CDK2 Inhibitor 19 CDK5 Inhibitor 7 CDK9 Inhibitor 16

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Bortezomib + Dexamethasone + Dinaciclib Bortezomib Dexamethasone Dinaciclib 0 1
Carboplatin + Dinaciclib + Veliparib Carboplatin Dinaciclib Veliparib 0 0
Dinaciclib Dinaciclib 7 0
Dinaciclib + Doxorubicin Dinaciclib Doxorubicin 1 0
Dinaciclib + MK2206 Dinaciclib MK2206 0 1
Dinaciclib + Olaparib Dinaciclib Olaparib 0 0
Dinaciclib + Paclitaxel Dinaciclib Paclitaxel 1 0
Dinaciclib + Pembrolizumab Dinaciclib Pembrolizumab 0 2
Dinaciclib + Veliparib Dinaciclib Veliparib 1 1
Dinaciclib + Venetoclax Dinaciclib Venetoclax 0 1


Additional content available in CKB BOOST