Therapy Detail
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| Therapy Name | Dinaciclib |
| Synonyms | |
| Therapy Description |
Dinaciclib (SCH 727965) inhibits cyclin dependent kinases CDK1, CDK2, CDK5, CDK9, and CDK12, which prevents phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 24900195, PMID: 24004674, PMID: 27880910). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Dinaciclib | SCH727965|MK-7965 | CDK1 Inhibitor 13 CDK2 Inhibitor 18 CDK5 Inhibitor 7 CDK9 Inhibitor 16 | Dinaciclib (SCH 727965) inhibits cyclin dependent kinases CDK1, CDK2, CDK5, CDK9, and CDK12, which prevents phosphorylation of downstream targets and may promote cell cycle arrest and apoptosis in cancer cells (PMID: 24900195, PMID: 24004674, PMID: 27880910). |
Filtering
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- Simple literal full or partial string matches
- Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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- Use quotes to match a longer phrase which contains spaces "mtor c1483f"
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KMT2A - MLLT3 | acute myeloid leukemia | sensitive | Dinaciclib | Preclinical | Actionable | In a preclinical study, treatment with Dinaciclib resulted in induced cell death of acute myeloid leukemia cells harboring KMT2A-MLLT3 in culture (PMID: 26627013). | 26627013 |
| KMT2A - AFF1 | acute myeloid leukemia | sensitive | Dinaciclib | Preclinical | Actionable | In a preclinical study, treatment with Dinaciclib resulted in induced cell death of acute myeloid leukemia cells harboring KMT2A-AFF1 in culture (PMID: 26627013). | 26627013 |
| Unknown unknown | multiple myeloma | not applicable | Dinaciclib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Dinaciclib (SCH 727965) decreased cell viability and growth of multiple myeloma cell lines in culture, and decreased tumor growth in multiple myeloma cell line xenograft models (PMID: 26719576). | 26719576 |
| KMT2A - MLLT1 NRAS G12D | acute myeloid leukemia | sensitive | Dinaciclib | Preclinical | Actionable | In a preclinical study, acute myeloid leukemia cells co-harboring KMT2A-MLLT1 and NRAS G12D demonstrated a decrease in tumor burden, reduced colony formation, and an increase in cell death when treated with Dinaciclib in both culture and mouse models (PMID: 26627013). | 26627013 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status |
|---|
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