Disease Detail

ID DOID:3910
Name lung adenocarcinoma
Definition A lung cancer that derives_from epithelial cells of glandular origin.
Source DiseaseOntology.org
Alt Ids DOID:4826 DOID:3909
Path disease disease of cellular proliferation cancer organ system cancer respiratory system cancer lung cancer lung adenocarcinoma

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
EGFR L858R Rociletinib lung adenocarcinoma sensitive detail...
MAP2K1 K57N Selumetinib lung adenocarcinoma sensitive detail...
PIK3CA H1047R BEZ235 lung adenocarcinoma sensitive detail...
PIK3CA H1047R Sirolimus lung adenocarcinoma no benefit detail...
FBXW7 R465H Temsirolimus lung adenocarcinoma sensitive detail...
FGFR3-TACC3 Ponatinib lung adenocarcinoma sensitive detail...
FGFR3-TACC3 BGJ398 lung adenocarcinoma sensitive detail...
ROS1 rearrange Crizotinib lung adenocarcinoma sensitive detail...
ERBB2 mutant Afatinib lung adenocarcinoma sensitive detail...
EGFR E746_A750del Gefitinib lung adenocarcinoma predicted - sensitive detail...
EGFR E746_A750del EGFR T790M Erlotinib lung adenocarcinoma predicted - resistant detail...
EGFR E746_A750del EGFR T790M Gefitinib lung adenocarcinoma predicted - resistant detail...
EGFR L747_T751delinsP Gefitinib lung adenocarcinoma predicted - sensitive detail...
EGFR L747_T751delinsP EGFR T790M Gefitinib lung adenocarcinoma predicted - resistant detail...
EGFR L747_S752del Gefitinib lung adenocarcinoma predicted - sensitive detail...
EGFR L747_T751delinsP EGFR T790M Erlotinib lung adenocarcinoma predicted - resistant detail...
EGFR L747_S752del EGFR T790M Gefitinib lung adenocarcinoma predicted - resistant detail...
EGFR L747_S752del EGFR T790M Erlotinib lung adenocarcinoma predicted - resistant detail...
EGFR L858R EGFR L747S Gefitinib lung adenocarcinoma predicted - resistant detail...
EGFR L858R EGFR L747S Erlotinib lung adenocarcinoma decreased response detail...
EGFR L858R Cetuximab lung adenocarcinoma sensitive detail...
EGFR mutant Poziotinib lung adenocarcinoma sensitive detail...
ALK rearrange ALK I1171T Alectinib lung adenocarcinoma resistant detail...
ALK rearrange ALK I1171T Crizotinib lung adenocarcinoma resistant detail...
Unknown unknown Nintedanib lung adenocarcinoma not applicable detail...
EGFR E709_T710delinsD Afatinib lung adenocarcinoma sensitive detail...
EGFR L858R EGFR T790M Osimertinib + Selumetinib lung adenocarcinoma sensitive detail...
EGFR L858R Osimertinib + Selumetinib lung adenocarcinoma sensitive detail...
EGFR G696_P1033dup Afatinib lung adenocarcinoma predicted - sensitive detail...
EGFR amp EGFR G696_P1033dup Afatinib lung adenocarcinoma predicted - resistant detail...
EGFR L858R EGFR T790M Afatinib lung adenocarcinoma resistant detail...
EGFR exon 19 del EGFR T790M Afatinib lung adenocarcinoma resistant detail...
EGFR C797S EGFR exon 19 del EGFR T790M Gefitinib lung adenocarcinoma resistant detail...
EGFR C797S EGFR exon 19 del EGFR T790M WZ4002 lung adenocarcinoma resistant detail...
EGFR C797S EGFR exon 19 del EGFR T790M Afatinib lung adenocarcinoma resistant detail...
EGFR C797S EGFR exon 19 del Gefitinib lung adenocarcinoma sensitive detail...
EGFR C797S EGFR exon 19 del Afatinib lung adenocarcinoma sensitive detail...
EGFR C797S EGFR exon 19 del WZ4002 lung adenocarcinoma resistant detail...
EGFR mutant N/A lung adenocarcinoma not applicable detail...
MAP2K1 Q56P Trametinib lung adenocarcinoma sensitive detail...
MAP2K1 Q56P Selumetinib lung adenocarcinoma sensitive detail...
MAP2K1 Q56P Refametinib lung adenocarcinoma sensitive detail...
MAP2K1 Q56P PD-0325901 lung adenocarcinoma sensitive detail...
EGFR L858R Afatinib + Cetuximab lung adenocarcinoma sensitive detail...
EGFR L858R EGFR T790M Erlotinib lung adenocarcinoma resistant detail...
EGFR L858R EGFR T790M Afatinib + Cetuximab lung adenocarcinoma resistant detail...
EGFR T790M Afatinib lung adenocarcinoma resistant detail...
BRAF mutant Trametinib lung adenocarcinoma sensitive detail...
NRAS mutant Trametinib lung adenocarcinoma resistant detail...
EGFR L833V EGFR H835L Gefitinib lung adenocarcinoma predicted - sensitive detail...
EGFR amp EGFR E746_A750del Depatuxizumab mafodotin lung adenocarcinoma sensitive detail...
ABL1 R332W Imatinib lung adenocarcinoma sensitive detail...
ABL1 G321L Imatinib lung adenocarcinoma sensitive detail...
ABL1 R332W ABL1 T315I Imatinib lung adenocarcinoma resistant detail...
ABL1 R332W Dasatinib lung adenocarcinoma sensitive detail...
ABL1 G321L Dasatinib lung adenocarcinoma sensitive detail...
ABL1 R332W ABL1 T315I Dasatinib lung adenocarcinoma resistant detail...
IDH1 mutant Dasatinib lung adenocarcinoma resistant detail...
ERBB2 exon 20 ins Afatinib lung adenocarcinoma predicted - sensitive detail...
ERBB2 Y772_A775dup Afatinib lung adenocarcinoma conflicting detail...
EGFR L858R EGFR T790M JNJ-61186372 lung adenocarcinoma sensitive detail...
EGFR exon 19 del JNJ-61186372 lung adenocarcinoma sensitive detail...
EGFR-RAD51 Erlotinib lung adenocarcinoma predicted - sensitive detail...
EGFR-PURB Erlotinib lung adenocarcinoma predicted - sensitive detail...
ERBB2 G778_P780dup Afatinib lung adenocarcinoma predicted - sensitive detail...
EGFR L858R EGFR T790M Afatinib + Cetuximab + Sirolimus lung adenocarcinoma sensitive detail...
EGFR T790M ERBB2 over exp Osimertinib lung adenocarcinoma resistant detail...
EGFR T790M ERBB2 over exp Rociletinib lung adenocarcinoma resistant detail...
EGFR T790M MET amp Rociletinib lung adenocarcinoma resistant detail...
EGFR T790M MET amp Osimertinib lung adenocarcinoma resistant detail...
EGFR E746_A750del Avitinib maleate lung adenocarcinoma sensitive detail...
EGFR exon 19 del EGFR T790M MET amp Osimertinib lung adenocarcinoma predicted - resistant detail...
EGFR exon 19 del EGFR T790M MET amp Crizotinib lung adenocarcinoma predicted - sensitive detail...
FGFR1 positive AZD4547 + AZD8055 lung adenocarcinoma sensitive detail...
FGFR1 positive AZD4547 + Vistusertib lung adenocarcinoma sensitive detail...
FGFR1 positive AZD4547 + Sirolimus lung adenocarcinoma sensitive detail...
EGFR exon 19 del MET amp Afatinib lung adenocarcinoma predicted - resistant detail...
EGFR exon 19 del MET amp Erlotinib lung adenocarcinoma resistant detail...
EGFR exon 19 del MET amp Osimertinib + Savolitinib lung adenocarcinoma predicted - sensitive detail...
EGFR exon 19 del MET amp MET D1228V Cabozantinib + Erlotinib lung adenocarcinoma predicted - sensitive detail...
MET amp MET del exon14 Cabozantinib lung adenocarcinoma predicted - sensitive detail...
MET del exon14 Crizotinib lung adenocarcinoma predicted - sensitive detail...
BRAF G469L Vemurafenib lung adenocarcinoma no benefit detail...
MET over exp Merestinib lung adenocarcinoma sensitive detail...
MET over exp Telisotuzumab vedotin lung adenocarcinoma predicted - sensitive detail...
BRAF N581S PF-00477736 + PF3644022 lung adenocarcinoma predicted - sensitive detail...
ERBB2 L869R Lapatinib lung adenocarcinoma predicted - resistant detail...
EGFR G719A EGFR L861Q Erlotinib lung adenocarcinoma predicted - sensitive detail...
EGFR G719A EGFR L861Q EGFR T790M Erlotinib lung adenocarcinoma predicted - resistant detail...
EGFR G719A EGFR L861Q EGFR T790M Osimertinib lung adenocarcinoma predicted - sensitive detail...
ERBB2 M774delinsWLV Dacomitinib lung adenocarcinoma sensitive detail...
ERBB2 G778_P780dup Dacomitinib lung adenocarcinoma sensitive detail...
EGFR N771_H773dup Dacomitinib lung adenocarcinoma sensitive detail...
EGFR P772_H773insPNP Dacomitinib lung adenocarcinoma sensitive detail...
EGFR P772_H773insPNP Afatinib lung adenocarcinoma sensitive detail...
EGFR N771_H773dup Afatinib lung adenocarcinoma sensitive detail...
EGFR act mut Bevacizumab + Erlotinib lung adenocarcinoma sensitive detail...
EGFR act mut EGFR T790M Bevacizumab + Erlotinib lung adenocarcinoma sensitive detail...
EGFR exon 19 del Gefitinib + Golvatinib lung adenocarcinoma sensitive detail...
EGFR I740_K745dup Afatinib lung adenocarcinoma predicted - sensitive detail...
EGFR K739_I744dup Erlotinib lung adenocarcinoma predicted - sensitive detail...
EGFR K745_E746insTPVAIK Erlotinib lung adenocarcinoma predicted - sensitive detail...
AKT1 E17K Capivasertib lung adenocarcinoma predicted - sensitive detail...
Unknown unknown Docetaxel + Nintedanib lung adenocarcinoma not applicable detail...
MET amp MET del exon14 MET D1228N MET G1163R MET Y1230H MET Y1230S Crizotinib lung adenocarcinoma predicted - resistant detail...
MET del exon14 Glesatinib lung adenocarcinoma predicted - sensitive detail...
MET amp MET del exon14 Crizotinib lung adenocarcinoma predicted - sensitive detail...
MET amp MET del exon14 MET D1228N MET G1163R MET L1195V Glesatinib lung adenocarcinoma predicted - resistant detail...
FGFR3 positive Rogaratinib lung adenocarcinoma predicted - sensitive detail...
BRAF G469A PLX8394 lung adenocarcinoma sensitive detail...
BRAF G466V PLX8394 lung adenocarcinoma sensitive detail...
EGFR E746_A750del MET amp Osimertinib lung adenocarcinoma resistant detail...
EGFR E746_A750del MET amp Capmatinib lung adenocarcinoma sensitive detail...
EGFR E746_A750del MET amp Afatinib + Capmatinib lung adenocarcinoma sensitive detail...
EGFR E746_A750del MET amp Afatinib lung adenocarcinoma no benefit detail...
EGFR mut MET amp Erlotinib lung adenocarcinoma resistant detail...
EGFR mut MET amp EMD 1214063 + Erlotinib lung adenocarcinoma sensitive detail...
BRAF amp BRAF V600E SCH772984 lung adenocarcinoma decreased response detail...
BRAF amp BRAF V600E Dabrafenib + SCH772984 + Trametinib lung adenocarcinoma sensitive detail...
EGFR G719S EGFR T790M Afatinib lung adenocarcinoma predicted - resistant detail...
EGFR G719S EGFR T790M Osimertinib lung adenocarcinoma predicted - resistant detail...
ALK G1123S ALK rearrange Ceritinib lung adenocarcinoma predicted - resistant detail...
ALK G1123S ALK rearrange Alectinib lung adenocarcinoma predicted - sensitive detail...
EML4-ALK ALK C1156Y ALK L1196M Crizotinib lung adenocarcinoma predicted - resistant detail...
FGFR1 amp PRN1371 lung adenocarcinoma sensitive detail...
Unknown unknown AC-93253 iodide + Gefitinib lung adenocarcinoma predicted - sensitive detail...
ALK rearrange MET amp Alectinib lung adenocarcinoma resistant detail...
ALK rearrange MET amp Crizotinib lung adenocarcinoma sensitive detail...
EGFR exon 19 del Osimertinib lung adenocarcinoma sensitive detail...
BRAF V600E EGFR exon 19 del MET amp Osimertinib lung adenocarcinoma resistant detail...
EGFR L747P Gefitinib lung adenocarcinoma predicted - resistant detail...
EGFR L747P Bevacizumab + Erlotinib lung adenocarcinoma no benefit detail...
EGFR L747P Osimertinib lung adenocarcinoma predicted - resistant detail...
EGFR exon 19 del MET act mut Erlotinib lung adenocarcinoma predicted - resistant detail...
EGFR exon 19 del MET act mut Afatinib lung adenocarcinoma predicted - resistant detail...
EGFR exon 19 del MET act mut Osimertinib lung adenocarcinoma predicted - resistant detail...
EGFR exon 19 del MET act mut Afatinib + Crizotinib lung adenocarcinoma predicted - sensitive detail...
EGFR exon 19 del MET act mut Osimertinib + Saracatinib lung adenocarcinoma predicted - sensitive detail...
Unknown unknown JNJ-64041757 lung adenocarcinoma not applicable detail...
EGFR L858R EGFR T790M MET amp Crizotinib + Osimertinib lung adenocarcinoma predicted - sensitive detail...
EGFR L858R EGFR T790M MET amp Osimertinib lung adenocarcinoma predicted - resistant detail...
EGFR L858R EGFR T790M MET amp MET D1228H D1228N D1231Y Y1230H Crizotinib + Osimertinib lung adenocarcinoma predicted - resistant detail...
EGFR L858R EGFR T790M MET amp MET D1228H D1228N D1231Y Y1230H Cabozantinib + Osimertinib lung adenocarcinoma unknown detail...
EGFR L858R EGFR T790M MET amp MET D1231Y Cabozantinib + Osimertinib lung adenocarcinoma predicted - resistant detail...
RET M918T RET V804M Alectinib lung adenocarcinoma resistant detail...
EGFR A767_V769dup Poziotinib lung adenocarcinoma sensitive detail...
EGFR N771delinsFH Poziotinib lung adenocarcinoma sensitive detail...
EGFR exon 19 del EGFR K754E Erlotinib lung adenocarcinoma decreased response detail...
EGFR exon 19 del EGFR S645C Erlotinib lung adenocarcinoma resistant detail...
EGFR L858R EGFR T854A Erlotinib lung adenocarcinoma resistant detail...
EGFR E804G EGFR P699L Gefitinib lung adenocarcinoma predicted - resistant detail...
EGFR L747P Erlotinib lung adenocarcinoma predicted - resistant detail...
BRAF V600E NRAS Q61K Dabrafenib + Trametinib lung adenocarcinoma predicted - resistant detail...
ERBB2 exon 20 ins Dacomitinib lung adenocarcinoma predicted - sensitive detail...
ERBB2 amp Dacomitinib lung adenocarcinoma no benefit detail...
ERBB2 G776delinsVC Poziotinib lung adenocarcinoma predicted - sensitive detail...
ERBB2 Y772_A775dup Poziotinib lung adenocarcinoma predicted - sensitive detail...
ERBB2 E812K Poziotinib lung adenocarcinoma predicted - sensitive detail...
ERBB2 N813D Afatinib lung adenocarcinoma predicted - sensitive detail...
EGFR exon 19 del PTEN mut Erlotinib lung adenocarcinoma decreased response detail...
EGFR exon 19 del PTEN mut Gefitinib lung adenocarcinoma decreased response detail...
EGFR L858R PTEN mut Gefitinib lung adenocarcinoma decreased response detail...
EGFR L858R PTEN mut Erlotinib lung adenocarcinoma decreased response detail...
EGFR T790M EGFR L792H Osimertinib lung adenocarcinoma predicted - resistant detail...
EGFR T790M EGFR G796R Osimertinib lung adenocarcinoma predicted - resistant detail...
EGFR exon 19 del EGFR T790M Nazartinib lung adenocarcinoma predicted - sensitive detail...
EGFR exon 19 del BRAF V600E Nazartinib lung adenocarcinoma predicted - resistant detail...
EGFR C797S EGFR exon 19 del EGFR T790M Nazartinib lung adenocarcinoma predicted - resistant detail...
EGFR exon 19 del EGFR T790M Olmutinib lung adenocarcinoma predicted - sensitive detail...
EGFR C797S EGFR exon 19 del EGFR T790M Olmutinib lung adenocarcinoma predicted - resistant detail...
EGFR G724S EGFR E746_S752delinsV EGFR T790M Osimertinib lung adenocarcinoma predicted - resistant detail...
ERBB2 act mut Ado-trastuzumab emtansine lung adenocarcinoma predicted - sensitive detail...
ERBB2 A775_G776insYVMA Ado-trastuzumab emtansine lung adenocarcinoma predicted - sensitive detail...
ERBB2 G778_P780dup Ado-trastuzumab emtansine lung adenocarcinoma predicted - sensitive detail...
ERBB2 G776delinsVC Ado-trastuzumab emtansine lung adenocarcinoma predicted - sensitive detail...
ERBB2 V659E Ado-trastuzumab emtansine lung adenocarcinoma predicted - sensitive detail...
ERBB2 amp ERBB2 S310F Ado-trastuzumab emtansine lung adenocarcinoma predicted - sensitive detail...
EGFR E746_S752delinsV MET-UBE2H Erlotinib lung adenocarcinoma predicted - resistant detail...
EGFR E746_S752delinsV MET-UBE2H Crizotinib lung adenocarcinoma predicted - sensitive detail...
EGFR exon 19 del MET amp MET D1228V Osimertinib + Savolitinib lung adenocarcinoma predicted - resistant detail...
EGFR L747P Afatinib lung adenocarcinoma predicted - sensitive detail...
EGFR H773L EGFR V774M Afatinib lung adenocarcinoma predicted - resistant detail...
EGFR-RAD51 Icotinib lung adenocarcinoma predicted - sensitive detail...
EGFR-RAD51 Afatinib lung adenocarcinoma predicted - sensitive detail...
EGFR S768_V769delinsIL Gefitinib lung adenocarcinoma predicted - resistant detail...
EGFR E749Q Gefitinib lung adenocarcinoma predicted - resistant detail...
EGFR L858R EGFR T790M Lazertinib lung adenocarcinoma predicted - sensitive detail...
EGFR exon 19 del EGFR T790M Lazertinib lung adenocarcinoma predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01579994 Phase I Crizotinib + Ganetespib Crizotinib and Ganetespib (STA-9090) in ALK Positive Lung Cancers Active, not recruiting
NCT01737502 Phase Ib/II Auranofin + Sirolimus Sirolimus and Auranofin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer or Small Cell Lung Cancer Recruiting
NCT01814553 Phase III Afatinib + Loperamide ADAM-Afatinib Diarrhea Assessment and Management Completed
NCT01877083 Phase II Lenvatinib Study of the Safety and Activity of Lenvatinib (E7080) in Subjects With KIF5B-RET-Positive Adenocarcinoma of the Lung Completed
NCT01877811 Phase Ib/II RXDX-105 CEP-32496 in Patients With Advanced Solid Tumors in Phase 1 and Advanced Melanoma and Metastatic Colorectal Cancer in Phase 2 Completed
NCT01976741 Phase I Rogaratinib Phase I Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor Active, not recruiting
NCT02185690 Phase I Binimetinib + Carboplatin + Pemetrexed A Phase I/Ib Study of MEK162, a MEK Inhibitor, in Combination With Carboplatin and Pemetrexed in Patients With Non-squamous Carcinoma of the Lung Active, not recruiting
NCT02231164 Phase III Docetaxel Nintedanib LUME-Columbus: Nintedanib Plus Docetaxel in Advanced Non-small Cell Lung Cancer With Translational Research Terminated
NCT02264678 Phase Ib/II AZD6738 AZD6738 + Carboplatin AZD6738 + Durvalumab AZD6738 + Olaparib Ascending Doses of AZD6738 in Combination With Chemotherapy and/or Novel Anti Cancer Agents Recruiting
NCT02285855 Phase II Metformin Metformin in Non Small Cell Lung Cancer (NSCLC) Terminated
NCT02450175 Phase I Letrozole Everolimus Etiology of the Platelet-Cancer Metastatic Pathway - A Study of Inflammatory Markers, Platelet Characteristics and Metastatic Surrogates in Cancer Patients and Controls Unknown status
NCT02450591 Phase I Erlotinib Local Therapies for Oligometastatic Non-Small Cell Lung Cancer Harboring Sensitizing EGFR Mutations Completed
NCT02466568 Phase Ib/II Nivolumab Study of Nivolumab in Combination With GM.CD40L Vaccine in Adenocarcinoma of the Lung Withdrawn
NCT02503358 Phase I Paclitaxel + Selumetinib Selumetinib and Paclitaxel as Second-Line Treatment in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer Recruiting
NCT02513667 Phase II Ceritinib Ceritinib in Combination With Stereotactic Ablative Radiation Metastatic Lung Adenocarcinoma Recruiting
NCT02705339 Phase II Rociletinib Rociletinib Genomic Landscape in Non-small Cell Lung Cancer (NSCLC) Withdrawn
NCT02759835 Phase II Osimertinib Local Ablative Therapy for Treatment of Oligoprogressive, EGFR-Mutated, Non-Small Cell Lung Cancer After Treatment With Osimertinib Recruiting
NCT02839681 Phase II Anetumab ravtansine Anti-Mesothelin Antibody Drug Conjugate Anetumab Ravtansine for Mesothelin Expressing Lung Adenocarcinoma Terminated
NCT02864992 Phase II Tepotinib Tepotinib Phase II Study in Lung Adenocarcinoma Harbouring MET Exon 14 (METex14) Skipping Alterations Recruiting
NCT03076164 Phase Ib/II Erlotinib + Trametinib A Phase 1/2 Trial of Trametinib and Erlotinib in Patients With EGFR-Mutant Lung Adenocarcinomas and Acquired Resistance to Erlotinib Recruiting
NCT03255083 Phase I DS-1205c + Osimertinib DS-1205c With Osimertinib for Metastatic or Unresectable Epidermal Growth Factor Receptor (EGFR)-Mutant Non-Small Cell Lung Cancer Recruiting
NCT03371381 Phase Ib/II JNJ-64041757 + Nivolumab Nivolumab An Efficacy and Safety Study of JNJ-64041757, a Live Attenuated Listeria Monocytogenes Immunotherapy, in Combination With Nivolumab Versus Nivolumab Monotherapy in Participants With Advanced Adenocarcinoma of the Lung Terminated
NCT03476681 Phase I NEO-201 QUILT-3.017: Study of NEO-201 in Solid Tumors Recruiting
NCT03696212 Phase Ib/II Grapiprant + Pembrolizumab Grapiprant (ARY-007) and Pembrolizumab in Patients With Advanced or Metastatic Post-PD-1/L1 NSCLC Adenocarcinoma Recruiting
NCT03704688 Phase Ib/II Ponatinib + Trametinib Trial of Trametinib and Ponatinib in Patients With KRAS Mutant Advanced Non-Small Cell Lung Cancer Recruiting