Therapy Detail

Therapy Name Tepotinib
Synonym
Therapy Description

Tepotinib (MSC2156119J) selectively binds to the proto-oncogene hepatocyte growth factor receptor (HGFR or c-Met), which inhibits c-Met phosphorylation and disrupts c-Met-mediated signaling pathways, thereby suppressing tumor growth in tumor cells with activated or overexpression of c-Met protein (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tepotinib MSC2156119J MET Inhibitor 51 Tepotinib (MSC2156119J) selectively binds to the proto-oncogene hepatocyte growth factor receptor (HGFR or c-Met), which inhibits c-Met phosphorylation and disrupts c-Met-mediated signaling pathways, thereby suppressing tumor growth in tumor cells with activated or overexpression of c-Met protein (NCI Drug Dictionary).
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
MET amp Advanced Solid Tumor sensitive Tepotinib Phase I Actionable In a Phase I study, Tepotinib (MSC2156119J) demonstrated safety and preliminary efficacy in advanced solid tumor patients with MET amplification (JCO, Vol 33, No 15_suppl (May 20 Supplement), 2015: 2591). detail...
MET act mut hepatocellular carcinoma sensitive Tepotinib Preclinical Actionable In a preclinical study, Tepotinib (MSC2156119J) inhibited tumor growth in hepatocellular cancer (HCC) mouse xenograft models with MET overexpression or activation (Cancer Res April 15, 2013; 73(8 Supplement): 925) detail...
MET over exp hepatocellular carcinoma sensitive Tepotinib Preclinical - Pdx Actionable In a preclinical study, Tepotinib (MSC2156119J) treatment resulted in tumor regression in patient-derived xenograft models of hepatocellular cancer with high Met expression level (PMID: 25256830). 25256830
MET exon 14 non-small cell lung carcinoma predicted - sensitive Tepotinib Phase II Actionable In a Phase II trial, Tepotinib (MSC2156119J) treatment resulted in partial response in 60.0% (9/15) and stable disease in 20% (3/15) of patients with non-small cell lung cancer harboring MET exon 14 skipping mutations (J Clin Oncol 36, 2018 (suppl; abstr 9016); NCT02864992). detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT02864992 Phase II Tepotinib Tepotinib Phase II Study in Lung Adenocarcinoma Harbouring MET Exon 14 (METex14) Skipping Alterations Recruiting