Therapy Detail

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Therapy Name Tepotinib
Synonyms
Therapy Description

Tepotinib (MSC2156119J) selectively binds to the proto-oncogene hepatocyte growth factor receptor (HGFR or c-Met), which inhibits c-Met phosphorylation and disrupts c-Met-mediated signaling pathways, thereby suppressing tumor growth in tumor cells with activated or overexpression of c-Met protein (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Tepotinib EMD1214063|EMD-1214063EMD 1214063|MSC2156119|MSC-2156119|MSC2156119J MET Inhibitor 51 Tepotinib (EMD-1214063) selectively binds to the proto-oncogene hepatocyte growth factor receptor (HGFR or c-Met), which inhibits c-Met phosphorylation and disrupts c-Met-mediated signaling pathways, thereby suppressing tumor growth in tumor cells with activated or overexpression of c-Met protein (PMID: 32328660).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown Advanced Solid Tumor not applicable Tepotinib Phase I Actionable In a Phase I trial, treatment with Tepotinib (EMD-1214063) was well-tolerated, demonstrated safety, and resulted in some antitumor efficacy in Japanese patients with an advanced solid tumor including stable disease for 12 weeks or more in two patients, a gastric cancer patient with MET expression and another patient with urachal cancer (PMID: 32328660). 32328660
Unknown unknown glioblastoma multiforme not applicable Tepotinib Preclinical Actionable In a preclinical study, Tepotinib (EMD-1214063) induced tumor regression in mouse cell line xenograft models of glioblastoma (PMID: 23553846). 23553846
Unknown unknown pancreatic carcinoma not applicable Tepotinib Preclinical - Cell line xenograft Actionable In a preclinical study, Tepotinib (EMD-1214063) induced tumor regression in mouse cell line xenograft models of pancreatic carcinoma (PMID: 23553846). 23553846

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02864992 Phase II Tepotinib Tepotinib Phase II in Non-small Cell Lung Cancer (NSCLC) Harboring MET Alterations (VISION) Recruiting
NCT03940703 Phase II Osimertinib + Tepotinib Tepotinib A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed Mesenchymal-epithelial Transition Factor (MET) Amplified Non-small Cell Lung Cancer (NSCLC) (INSIGHT 2) (INSIGHT 2) Recruiting
NCT01014936 Phase I Tepotinib First-in-Man, Dose-escalation Trial of C-met Kinase Inhibitor MSC2156119J in Subjects With Advanced Solid Tumors Completed


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