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Drug Name Tepotinib
Trade Name Tepmetko
Synonyms EMD1214063|EMD-1214063|EMD 1214063|MSC2156119|MSC-2156119|MSC2156119J
Drug Descriptions

Tepmetko (tepotinib) selectively binds to the proto-oncogene hepatocyte growth factor receptor (HGFR or c-Met), which inhibits c-Met phosphorylation and disrupts c-Met-mediated signaling pathways, thereby suppressing tumor growth in tumor cells with activated or overexpression of c-Met protein (PMID: 32328660). Tepmetko (tepotinib) is FDA approved for use in patients with metastatic non-small cell lung cancer harboring MET exon 14 skipping mutations (FDA.gov).

DrugClasses MET Inhibitor 54
CAS Registry Number 1100598-32-0
NCIT ID C88314

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + Tepotinib Cetuximab Tepotinib 0 1
Erlotinib + Tepotinib Erlotinib Tepotinib 0 0
Infigratinib + Tepotinib Infigratinib Tepotinib 0 0
Osimertinib + Tepotinib Osimertinib Tepotinib 0 1
Radiotherapy + Tepotinib Radiotherapy Tepotinib 0 0
Tepotinib Tepotinib 0 3


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