Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Tepotinib
Trade Name Tepmetko
Synonyms EMD1214063|EMD-1214063|EMD 1214063|MSC2156119|MSC-2156119|MSC2156119J
Drug Descriptions

Tepmetko (tepotinib) selectively binds to the proto-oncogene hepatocyte growth factor receptor (HGFR or c-Met), which inhibits c-Met phosphorylation and disrupts c-Met-mediated signaling pathways, thereby suppressing tumor growth in tumor cells with activated or overexpression of c-Met protein (PMID: 32328660). Tepmetko (tepotinib) is FDA approved for use in patients with metastatic non-small cell lung cancer harboring MET exon 14 skipping mutations (FDA.gov).

DrugClasses MET Inhibitor 59
CAS Registry Number 1100598-32-0
NCIT ID C88314


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Amivantamab-vmjw + Tepotinib Amivantamab-vmjw Tepotinib 0 1
Cetuximab + Tepotinib Cetuximab Tepotinib 0 1
Entrectinib + Tepotinib Entrectinib Tepotinib 0 0
Erlotinib + Tepotinib Erlotinib Tepotinib 0 0
Gefitinib + Tepotinib Gefitinib Tepotinib 0 0
Infigratinib + Tepotinib Infigratinib Tepotinib 0 0
Osimertinib + Tepotinib Osimertinib Tepotinib 0 2
Pembrolizumab + Tepotinib Pembrolizumab Tepotinib 0 1
Poziotinib + Tepotinib Poziotinib Tepotinib 0 0
Radiotherapy + Tepotinib Radiotherapy Tepotinib 0 0
Sotorasib + Tepotinib Sotorasib Tepotinib 0 0
Tepotinib Tepotinib 0 6

Additional content available in CKB BOOST