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Drug Name Infigratinib
Trade Name Truseltiq
Synonyms BGJ398|BGJ-398|BGJ 398
Drug Descriptions

Truseltiq (infigratinib) is a pan-FGFR inhibitor, which inhibits tumor angiogenesis and tumor cell proliferation (PMID: 31109923, PMID: 30101387). Truseltiq (infigratinib) is FDA approved for use in patients with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma harboring FGFR2 fusion or rearrangement (FDA.gov).

DrugClasses FGFR Inhibitor (Pan) 19
CAS Registry Number 872511-34-7
NCIT ID C88302

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ABT-737 + Infigratinib ABT-737 Infigratinib 3 0
Alpelisib + Infigratinib Alpelisib Infigratinib 3 1
Binimetinib + Encorafenib + Infigratinib Binimetinib Encorafenib Infigratinib 0 1
Buparlisib + Infigratinib Buparlisib Infigratinib 2 0
Crizotinib + Infigratinib Crizotinib Infigratinib 0 0
Deltarasin + Infigratinib Deltarasin Infigratinib 0 0
Encorafenib + Infigratinib Encorafenib Infigratinib 0 1
Fluorouracil + Infigratinib Fluorouracil Infigratinib 0 0
Fluorouracil + Infigratinib + Irinotecan + Oxaliplatin Fluorouracil Infigratinib Irinotecan Oxaliplatin 0 1
Fulvestrant + Infigratinib + Palbociclib Fulvestrant Infigratinib Palbociclib 0 1
Ganetespib + Infigratinib Ganetespib Infigratinib 1 0
Gefitinib + Infigratinib Gefitinib Infigratinib 0 0
Imatinib + Infigratinib Imatinib Infigratinib 5 1
Infigratinib Infigratinib 155 13
Infigratinib + Navitoclax Infigratinib Navitoclax 1 0
Infigratinib + Olaparib Infigratinib Olaparib 0 0
Infigratinib + Oxaliplatin Infigratinib Oxaliplatin 0 0
Infigratinib + Pictilisib Infigratinib Pictilisib 1 0
Infigratinib + Sapanisertib Infigratinib Sapanisertib 2 0
Infigratinib + Talazoparib Infigratinib Talazoparib 0 0
Infigratinib + Tamoxifen Infigratinib Tamoxifen 0 1
Infigratinib + Tepotinib Infigratinib Tepotinib 0 0
Infigratinib + Trabectedin Infigratinib Trabectedin 1 0
Infigratinib + Trametinib Infigratinib Trametinib 8 0


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