Drug Detail


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Drug Name Vandetanib
Trade Name Caprelsa
Synonyms ZD6474
Drug Descriptions

Caprelsa (vandetanib) is a multi-tyrosine kinase inhibitor with activity against VEGFR, EGFR, RET, SRC, and ABL1 kinases, potentially resulting in decreased tumor growth (PMID: 25031937, PMID: 25490448). Caprelsa (vandetanib) is FDA approved for use in medullary thyroid cancer (FDA.gov).

DrugClasses ABL1 Inhibitor 7 EGFR Inhibitor (Pan) 55 RET Inhibitor 48 SRC Inhibitor 31 VEGFR Inhibitor (Pan) 33
CAS Registry Number 443913-73-3


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Alisertib + Vandetanib Alisertib Vandetanib 0 0
AT9283 + Vandetanib AT9283 Vandetanib 0 0
Barasertib + Vandetanib Barasertib Vandetanib 0 0
Cabozantinib + Vandetanib Cabozantinib Vandetanib 0 1
Capecitabine + Oxaliplatin + Vandetanib Capecitabine Oxaliplatin Vandetanib 0 0
Carboplatin + Fluorouracil + Paclitaxel + Vandetanib Carboplatin Fluorouracil Paclitaxel Vandetanib 0 1
Cyclophosphamide + Methotrexate + Vandetanib Cyclophosphamide Methotrexate Vandetanib 0 0
Dasatinib + Vandetanib Dasatinib Vandetanib 0 0
Docetaxel + Vandetanib Docetaxel Vandetanib 0 0
Everolimus + Vandetanib Everolimus Vandetanib 2 1
Fluorouracil + Leucovorin + Oxaliplatin + Vandetanib Fluorouracil Leucovorin Oxaliplatin Vandetanib 0 0
Gemcitabine + Vandetanib Gemcitabine Vandetanib 0 0
Metformin + Vandetanib Metformin Vandetanib 0 1
Temozolomide + Vandetanib Temozolomide Vandetanib 2 0
Vandetanib Vandetanib 23 9
Vandetanib + XAV939 Vandetanib XAV939 0 0

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