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Drug Name Alisertib
Trade Name
Synonyms MLN8237
Drug Descriptions

Alisertib (MLN8237) binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation (PMID: 26999067).

DrugClasses Aurka Inhibitors 23

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Alisertib + Prednisone Abiraterone Alisertib Prednisone 0 0
Alisertib Alisertib 18 19
Alisertib + Bortezomib + Rituximab Alisertib Bortezomib Rituximab 0 1
Alisertib + Brentuximab vedotin Alisertib Brentuximab vedotin 0 1
Alisertib + Carboplatin + Cyclophosphamide + Etoposide Alisertib Carboplatin Cyclophosphamide Etoposide 0 1
Alisertib + Carboplatin + Cyclophosphamide + Vincristine Alisertib Carboplatin Cyclophosphamide Vincristine 0 1
Alisertib + Cisplatin Alisertib Cisplatin 0 0
Alisertib + Cisplatin + Cyclophosphamide + Vincristine Alisertib Cisplatin Cyclophosphamide Vincristine 0 1
Alisertib + Cisplatin + Etoposide Alisertib Cisplatin Etoposide 0 0
Alisertib + Docetaxel Alisertib Docetaxel 1 0
Alisertib + Eribulin Alisertib Eribulin 1 0
Alisertib + Esomeprazole Alisertib Esomeprazole 0 1
Alisertib + Etoposide Alisertib Etoposide 0 0
Alisertib + Fulvestrant Alisertib Fulvestrant 1 1
Alisertib + Gemcitabine Alisertib Gemcitabine 0 1
Alisertib + Irinotecan Alisertib Irinotecan 0 1
Alisertib + Irinotecan + Temozolomide Alisertib Irinotecan Temozolomide 2 1
Alisertib + MLN2480 Alisertib MLN2480 0 1
Alisertib + MP7 Alisertib MP7 1 0
Alisertib + Nab-paclitaxel Alisertib Nab-paclitaxel 0 1
Alisertib + Osimertinib Alisertib Osimertinib 0 1
Alisertib + Paclitaxel Alisertib Paclitaxel 2 1
Alisertib + Palbociclib Alisertib Palbociclib 2 0
Alisertib + Pazopanib Alisertib Pazopanib 0 1
Alisertib + Rifampin Alisertib Rifampin 0 1
Alisertib + Rituximab Alisertib Rituximab 1 0
Alisertib + Rituximab + Vincristine Alisertib Rituximab Vincristine 1 0
Alisertib + Sapanisertib Alisertib Sapanisertib 0 2
Alisertib + Tamoxifen Alisertib Tamoxifen 0 0
Alisertib + Venetoclax Alisertib Venetoclax 0 0


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