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Drug Name Alisertib
Trade Name
Synonyms MLN8237
Drug Descriptions

Alisertib (MLN8237) binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation (PMID: 26999067, PMID: 32414750).

DrugClasses Aurka Inhibitors 26
CAS Registry Number 1028486-01-2
NCIT ID C71717

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abiraterone + Alisertib + Prednisone Abiraterone Alisertib Prednisone 0 0
Alisertib Alisertib 0 20
Alisertib + Anastrozole Alisertib Anastrozole 0 1
Alisertib + Bortezomib + Rituximab Alisertib Bortezomib Rituximab 0 1
Alisertib + Brentuximab vedotin Alisertib Brentuximab vedotin 0 1
Alisertib + Carboplatin + Cyclophosphamide + Etoposide Alisertib Carboplatin Cyclophosphamide Etoposide 0 1
Alisertib + Carboplatin + Cyclophosphamide + Vincristine Sulfate Alisertib Carboplatin Cyclophosphamide Vincristine Sulfate 0 1
Alisertib + Cetuximab Alisertib Cetuximab 0 1
Alisertib + Cisplatin Alisertib Cisplatin 0 0
Alisertib + Cisplatin + Cyclophosphamide + Vincristine Sulfate Alisertib Cisplatin Cyclophosphamide Vincristine Sulfate 0 1
Alisertib + Cisplatin + Etoposide Alisertib Cisplatin Etoposide 0 0
Alisertib + Docetaxel Alisertib Docetaxel 0 0
Alisertib + Eribulin Alisertib Eribulin 0 0
Alisertib + Esomeprazole Alisertib Esomeprazole 0 1
Alisertib + Etoposide Alisertib Etoposide 0 0
Alisertib + Exemestane Alisertib Exemestane 0 1
Alisertib + Fulvestrant Alisertib Fulvestrant 0 2
Alisertib + Gemcitabine Alisertib Gemcitabine 0 1
Alisertib + Irinotecan Alisertib Irinotecan 0 1
Alisertib + Irinotecan + Temozolomide Alisertib Irinotecan Temozolomide 0 1
Alisertib + Letrozole Alisertib Letrozole 0 1
Alisertib + Mobocertinib Alisertib Mobocertinib 0 0
Alisertib + MP7 Alisertib MP7 0 0
Alisertib + Nab-paclitaxel Alisertib Nab-paclitaxel 0 1
Alisertib + Neratinib Alisertib Neratinib 0 0
Alisertib + Osimertinib Alisertib Osimertinib 0 2
Alisertib + Paclitaxel Alisertib Paclitaxel 0 1
Alisertib + Palbociclib Alisertib Palbociclib 2 0
Alisertib + Pazopanib Alisertib Pazopanib 0 1
Alisertib + Pembrolizumab Alisertib Pembrolizumab 0 1
Alisertib + Rifampin Alisertib Rifampin 0 1
Alisertib + Rituximab Alisertib Rituximab 0 0
Alisertib + Rituximab + Vincristine Sulfate Alisertib Rituximab Vincristine Sulfate 0 0
Alisertib + Sapanisertib Alisertib Sapanisertib 0 2
Alisertib + Tamoxifen Alisertib Tamoxifen 0 1
Alisertib + Tovorafenib Alisertib Tovorafenib 0 1
Alisertib + Vandetanib Alisertib Vandetanib 0 0
Alisertib + Venetoclax Alisertib Venetoclax 0 0
Alisertib + Vorinostat Alisertib Vorinostat 0 0


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