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Drug Name Pazopanib
Trade Name Votrient
Synonyms GW-786034
Drug Descriptions

Votrient (pazopanib) inhibits VEGFR-1, -2 and -3, KIT, and PDGFR, and FGFR1, 2, and 3, leading to decreased tumor angiogenesis and growth (PMID: 17620431, PMID: 23786770). Votrient (pazopanib) is approved for renal cell carcinoma and soft tissue sarcoma (FDA.gov).

DrugClasses FGFR1 Inhibitor 23 FGFR2 Inhibitor 15 FGFR3 Inhibitor 13 KIT Inhibitor 50 PDGFR Inhibitor (Pan) 27 VEGFR Inhibitor (Pan) 32

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abexinostat + Pazopanib Abexinostat Pazopanib 4 1
Alisertib + Pazopanib Alisertib Pazopanib 0 1
AR-42 + Pazopanib AR-42 Pazopanib 0 1
Bevacizumab + Pazopanib Bevacizumab Pazopanib 0 1
Carboplatin + Paclitaxel + Pazopanib Carboplatin Paclitaxel Pazopanib 1 0
Carotuximab + Pazopanib Carotuximab Pazopanib 2 3
Cetuximab + Pazopanib Cetuximab Pazopanib 1 1
Crizotinib + Pazopanib Crizotinib Pazopanib 0 1
Crizotinib + Pazopanib + Pemetrexed Crizotinib Pazopanib Pemetrexed 0 1
Dabrafenib + Pazopanib Dabrafenib Pazopanib 0 1
Docetaxel + Gemcitabine + Pazopanib Docetaxel Gemcitabine Pazopanib 0 2
Docetaxel + Pazopanib + Pegfilgrastim Docetaxel Pazopanib Pegfilgrastim 0 1
Doxorubicin + Ifosfamide + Pazopanib Doxorubicin Ifosfamide Pazopanib 0 1
Everolimus + Pazopanib Everolimus Pazopanib 1 1
Evofosfamide + Pazopanib Evofosfamide Pazopanib 0 1
Gemcitabine + Pazopanib Gemcitabine Pazopanib 2 3
Irinotecan + Pazopanib + Temozolomide Irinotecan Pazopanib Temozolomide 0 1
Nab-Rapamycin + Pazopanib Nab-Rapamycin Pazopanib 0 1
Nivolumab + Pazopanib Nivolumab Pazopanib 0 1
Paclitaxel + Pazopanib Paclitaxel Pazopanib 2 3
Panobinostat + Pazopanib Panobinostat Pazopanib 0 1
Pazopanib Pazopanib 28 41
Pazopanib + Pembrolizumab Pazopanib Pembrolizumab 1 0
Pazopanib + Pemetrexed Pazopanib Pemetrexed 0 1
Pazopanib + Sunitinib Pazopanib Sunitinib 0 1
Pazopanib + Temozolomide Pazopanib Temozolomide 0 1
Pazopanib + Topotecan Pazopanib Topotecan 0 5
Pazopanib + Trametinib Pazopanib Trametinib 4 1
Pazopanib + Trebananib Pazopanib Trebananib 0 1
Pazopanib + Vorinostat Pazopanib Vorinostat 0 0


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