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Drug Name Sunitinib
Trade Name Sutent
Synonyms SU011248
Drug Descriptions

Sutent (sunitinib) inhibits KDR (VEGFR2), PDGFR, c-KIT, FLT3, RET, and CSF1R, thereby inhibiting angiogenesis and cell proliferation (PMID: 25085632). Sutent (sunitinib) is approved for neuroendocrine tumors of the pancreas, advanced renal cell carcinoma, and GIST (FDA.gov).

DrugClasses CSF1R Inhibitor 28 FLT3 Inhibitor 66 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 RET Inhibitor 52 VEGFR2 Inhibitor 37
CAS Registry Number 557795-19-4
NCIT ID C71622

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Sunitinib Abemaciclib Sunitinib 0 1
Abiraterone + Sunitinib Abiraterone Sunitinib 0 1
AGS-003 + Sunitinib AGS-003 Sunitinib 0 0
Cabozantinib + Sunitinib Cabozantinib Sunitinib 0 2
Cetuximab + Sunitinib Cetuximab Sunitinib 0 0
Cisplatin + Sunitinib + Tamoxifen Cisplatin Sunitinib Tamoxifen 0 1
Crizotinib + Sunitinib Crizotinib Sunitinib 0 1
CVX-060 + Sunitinib CVX-060 Sunitinib 0 0
Cytarabine + Daunorubicin + Sunitinib Cytarabine Daunorubicin Sunitinib 1 0
Everolimus + Sunitinib Everolimus Sunitinib 0 0
HC-5404-FU + Sunitinib HC-5404-FU Sunitinib 0 0
Intuvax + Sunitinib Intuvax Sunitinib 0 0
Irinotecan + Sirolimus + Sunitinib + Temozolomide Irinotecan Sirolimus Sunitinib Temozolomide 0 0
Ixabepilone + Sunitinib Ixabepilone Sunitinib 0 0
JX-594 + Sunitinib JX-594 Sunitinib 0 0
Losartan + Sunitinib Losartan Sunitinib 0 1
lutetium Lu 177 dotatate + Sunitinib Sunitinib lutetium Lu 177 dotatate 0 1
LY2510924 + Sunitinib LY2510924 Sunitinib 0 0
M8891 + Sunitinib M8891 Sunitinib 1 0
Nivolumab + Sunitinib Nivolumab Sunitinib 0 2
Osimertinib + Sunitinib Osimertinib Sunitinib 0 0
Pazopanib + Sunitinib Pazopanib Sunitinib 0 1
Pembrolizumab + Sunitinib Pembrolizumab Sunitinib 0 1
PF-06755990 + PF-06755992 + Sunitinib + Tremelimumab PF-06755990 PF-06755992 Sunitinib Tremelimumab 0 1
PLX9486 + Sunitinib PLX9486 Sunitinib 0 3
PRT1419 + Sunitinib PRT1419 Sunitinib 0 0
PRT2527 + Sunitinib PRT2527 Sunitinib 0 0
PRX177561 + Sunitinib PRX177561 Sunitinib 0 0
Regorafenib + Sunitinib Regorafenib Sunitinib 0 0
Ripretinib + Sunitinib Ripretinib Sunitinib 5 0
SL327 + Sunitinib SL327 Sunitinib 0 0
Sorafenib + Sunitinib Sorafenib Sunitinib 1 0
Sunitinib Sunitinib 121 67
Sunitinib + Temozolomide Sunitinib Temozolomide 0 1
Sunitinib + Trametinib Sunitinib Trametinib 1 0
Sunitinib + Trastuzumab Sunitinib Trastuzumab 0 0
Sunitinib + Trebananib Sunitinib Trebananib 0 1
Sunitinib + Varlilumab Sunitinib Varlilumab 0 1


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