Drug Detail

Drug Name Sunitinib
Trade Name Sutent
Synonyms SU011248
Drug Descriptions

Sutent (sunitinib) inhibits KDR (VEGFR2), PDGFR, c-KIT, FLT3, RET, and CSF1R, thereby inhibiting angiogenesis and cell proliferation (PMID: 25085632). Sutent (sunitinib) is approved for neuroendocrine tumors of the pancreas, advanced renal cell carcinoma, and GIST (FDA.gov).

DrugClasses CSF1R Inhibitor 23 FLT3 Inhibitor 50 KIT Inhibitor 50 PDGFR Inhibitor (Pan) 27 RET Inhibitor 36 VEGFR2 Inhibitor 34

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Sunitinib Abemaciclib Sunitinib 0 1
Abiraterone + Sunitinib Abiraterone Sunitinib 0 1
AGS-003 + Sunitinib AGS-003 Sunitinib 1 0
Cabozantinib + Sunitinib Cabozantinib Sunitinib 0 2
Cetuximab + Sunitinib Cetuximab Sunitinib 1 0
Cisplatin + Sunitinib + Tamoxifen Cisplatin Sunitinib Tamoxifen 0 1
Crizotinib + Sunitinib Crizotinib Sunitinib 0 1
CVX-060 + Sunitinib CVX-060 Sunitinib 2 0
Cytarabine + Daunorubicin + Sunitinib Cytarabine Daunorubicin Sunitinib 1 0
Everolimus + Sunitinib Everolimus Sunitinib 1 0
Intuvax + Sunitinib Intuvax Sunitinib 0 0
Irinotecan + Sirolimus + Sunitinib + Temozolomide Irinotecan Sirolimus Sunitinib Temozolomide 1 0
Ixabepilone + Sunitinib Ixabepilone Sunitinib 1 0
LY2510924 + Sunitinib LY2510924 Sunitinib 0 0
Nivolumab + Sunitinib Nivolumab Sunitinib 0 1
Pazopanib + Sunitinib Pazopanib Sunitinib 0 1
Pembrolizumab + Sunitinib Pembrolizumab Sunitinib 0 1
PF-06755990 + PF-06755992 + Sunitinib + Tremelimumab PF-06755990 PF-06755992 Sunitinib Tremelimumab 0 1
PLX9486 + Sunitinib PLX9486 Sunitinib 0 1
PRX177561 + Sunitinib PRX177561 Sunitinib 1 0
Regorafenib + Sunitinib Regorafenib Sunitinib 0 0
SL327 + Sunitinib SL327 Sunitinib 1 0
Sunitinib Sunitinib 81 54
Sunitinib + Temozolomide Sunitinib Temozolomide 0 1
Sunitinib + Trametinib Sunitinib Trametinib 2 0
Sunitinib + Trastuzumab Sunitinib Trastuzumab 1 0
Sunitinib + Trebananib Sunitinib Trebananib 0 1
Sunitinib + Varlilumab Sunitinib Varlilumab 0 1


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