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Drug Name JX-594
Trade Name
Synonyms Pexastimogene devacirepvec|JX594|Pexa-vec|TG-6006
Drug Descriptions

Pexastimogene devacirepvec (JX-594) is a thymidine kinase-inactivated oncolytic vaccinia virus expressing human GM-CSF, which selectively infects transformed cells and induces cell death (PMID: 22186794).

CAS Registry Number 1058624-46-6
NCIT ID C71533


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Cyclophosphamide + JX-594 Avelumab Cyclophosphamide JX-594 0 1
Cemiplimab + JX-594 Cemiplimab JX-594 0 1
Cyclophosphamide + JX-594 Cyclophosphamide JX-594 0 1
Ipilimumab + JX-594 Ipilimumab JX-594 0 1
JX-594 JX-594 0 1
JX-594 + Sirolimus JX-594 Sirolimus 0 0
JX-594 + Sorafenib JX-594 Sorafenib 0 0
JX-594 + Sunitinib JX-594 Sunitinib 0 0

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