Drug Detail

Drug Name Sirolimus
Trade Name Rapamune
Synonyms Rapamycin
Drug Descriptions

Rapamune (sirolimus) binds to the FKBP-12 to generate an immunosuppressive complex that binds and allosterically inhibits mTOR (PMID: 25261369). Rapamune (sirolimus) is FDA approved for the prevention of renal transplant rejection and for patients with lymphangioleiomyomatosis (FDA.gov).

DrugClasses mTORC1 Inhibitor 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Cetuximab + Sirolimus Afatinib Cetuximab Sirolimus 0 0
Auranofin + Sirolimus Auranofin Sirolimus 0 2
Azacitidine + Sirolimus Azacitidine Sirolimus 0 1
AZD4547 + Sirolimus AZD4547 Sirolimus 2 0
Buthionine sufoximine + Sirolimus Buthionine sufoximine Sirolimus 0 0
Carboplatin + Docetaxel + Sirolimus Carboplatin Docetaxel Sirolimus 0 1
Celecoxib + Cyclophosphamide + Etoposide + Sirolimus Celecoxib Cyclophosphamide Etoposide Sirolimus 0 1
Celecoxib + Sirolimus Celecoxib Sirolimus 1 0
Cisplatin + Gemcitabine + Sirolimus Cisplatin Gemcitabine Sirolimus 0 2
Cyclophosphamide + Dexamethasone + Hydroxychloroquine + Sirolimus Cyclophosphamide Dexamethasone Hydroxychloroquine Sirolimus 0 1
Cyclophosphamide + Filgrastim + Mycophenolate mofetil + Sirolimus + Tacrolimus Cyclophosphamide Filgrastim Mycophenolate mofetil Sirolimus Tacrolimus 0 1
Cyclophosphamide + Fludarabine + Melphalan + Sirolimus Cyclophosphamide Fludarabine Melphalan Sirolimus 0 1
Cyclophosphamide + Sirolimus Cyclophosphamide Sirolimus 0 1
Cyclophosphamide + Sirolimus + Topotecan Cyclophosphamide Sirolimus Topotecan 0 1
Cyclosporine + Fludarabine + Mycophenolate mofetil + Sirolimus Cyclosporine Fludarabine Mycophenolate mofetil Sirolimus 0 1
Cyclosporine + Mycophenolate mofetil + Sirolimus Cyclosporine Mycophenolate mofetil Sirolimus 0 1
Cytarabine + Etoposide + Mitoxantrone + Sirolimus Cytarabine Etoposide Mitoxantrone Sirolimus 0 1
Cytarabine + Idarubicin + Sirolimus Cytarabine Idarubicin Sirolimus 0 1
Decitabine + Sirolimus Decitabine Sirolimus 0 1
Denileukin diftitox + Sirolimus Denileukin diftitox Sirolimus 4 0
Doxorubicin + Sirolimus Doxorubicin Sirolimus 1 0
Ensartinib + Sirolimus Ensartinib Sirolimus 1 0
Epacadostat + Sirolimus Epacadostat Sirolimus 0 1
Erlotinib + Sirolimus Erlotinib Sirolimus 0 1
Ganetespib + Sirolimus Ganetespib Sirolimus 0 1
Gemcitabine + Sirolimus Gemcitabine Sirolimus 1 0
H3B-5942 + Sirolimus H3B-5942 Sirolimus 0 0
Hydroxychloroquine + Sirolimus Hydroxychloroquine Sirolimus 0 1
Ipatasertib + Sirolimus Ipatasertib Sirolimus 0 0
Irinotecan + Sirolimus + Sunitinib + Temozolomide Irinotecan Sirolimus Sunitinib Temozolomide 1 0
Lapatinib + Sirolimus Lapatinib Sirolimus 0 1
Luminespib + Sirolimus Luminespib Sirolimus 0 0
LY294002 + Sirolimus LY294002 Sirolimus 0 0
MEDI-573 + Sirolimus MEDI-573 Sirolimus 1 0
Metformin + Sirolimus Metformin Sirolimus 0 2
Methotrexate + Sirolimus Methotrexate Sirolimus 0 1
Methotrexate + Sirolimus + Tacrolimus Methotrexate Sirolimus Tacrolimus 0 3
NY-ESO-1 peptide vaccine + Sirolimus NY-ESO-1 peptide vaccine Sirolimus 0 1
Palbociclib + Sirolimus Palbociclib Sirolimus 1 0
Pemetrexed + Sirolimus Pemetrexed Sirolimus 1 0
Pexidartinib + Sirolimus Pexidartinib Sirolimus 0 1
RU-SKI 43 + Sirolimus RU-SKI 43 Sirolimus 0 0
Ruxolitinib + Sirolimus + Tacrolimus Ruxolitinib Sirolimus Tacrolimus 0 1
Sapanisertib + Sirolimus Sapanisertib Sirolimus 0 0
SBI-0206965 + Sirolimus SBI-0206965 Sirolimus 1 0
Sirolimus Sirolimus 12 31
Sirolimus + Trametinib Sirolimus Trametinib 2 0
Sirolimus + Trastuzumab Sirolimus Trastuzumab 0 1
Sirolimus + UCN-01 Sirolimus UCN-01 1 0
Sirolimus + unspecified PD-1 antibody Sirolimus unspecified PD-1 antibody 0 0
Sirolimus + Vismodegib Sirolimus Vismodegib 0 1
Sirolimus + WEHI-539 Sirolimus WEHI-539 0 0