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Drug Name Sirolimus
Trade Name Rapamune
Synonyms Rapamycin
Drug Descriptions

Rapamune (sirolimus) binds to the FKBP-12 to generate an immunosuppressive complex that binds and allosterically inhibits mTOR (PMID: 25261369). Rapamune (sirolimus) is FDA approved for the prevention of renal transplant rejection and for patients with lymphangioleiomyomatosis (FDA.gov).

DrugClasses mTORC1 Inhibitor 9
CAS Registry Number 53123-88-9
NCIT ID C1212

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Therapy Name Drugs Efficacy Evidence Clinical Trials
7-hydroxystaurosporine + Sirolimus 7-hydroxystaurosporine Sirolimus 0 0
Afatinib + Cetuximab + Sirolimus Afatinib Cetuximab Sirolimus 0 0
ARQ 751 + Sirolimus ARQ 751 Sirolimus 1 0
Auranofin + Sirolimus Auranofin Sirolimus 0 2
Azacitidine + Sirolimus Azacitidine Sirolimus 0 1
AZD4547 + Sirolimus AZD4547 Sirolimus 2 0
AZD8055 + Sirolimus AZD8055 Sirolimus 0 0
BAY-293 + Sirolimus BAY-293 Sirolimus 0 0
Binimetinib + Ribociclib + Sirolimus Binimetinib Ribociclib Sirolimus 2 0
Buthionine sulfoximine + Sirolimus Buthionine sulfoximine Sirolimus 0 0
Carboplatin + Docetaxel + Sirolimus Carboplatin Docetaxel Sirolimus 0 1
Celecoxib + Cyclophosphamide + Etoposide + Sirolimus Celecoxib Cyclophosphamide Etoposide Sirolimus 0 2
Celecoxib + Sirolimus Celecoxib Sirolimus 0 0
Cemiplimab + Prednisone + Sirolimus Cemiplimab Prednisone Sirolimus 0 1
Cetuximab + Sirolimus Cetuximab Sirolimus 0 1
Cisplatin + Gemcitabine + Sirolimus Cisplatin Gemcitabine Sirolimus 0 2
Cyclophosphamide + Dexamethasone + Hydroxychloroquine + Sirolimus Cyclophosphamide Dexamethasone Hydroxychloroquine Sirolimus 0 1
Cyclophosphamide + Filgrastim + Mycophenolate mofetil + Sirolimus + Tacrolimus Cyclophosphamide Filgrastim Mycophenolate mofetil Sirolimus Tacrolimus 0 1
Cyclophosphamide + Fludarabine + Melphalan + Sirolimus Cyclophosphamide Fludarabine Melphalan Sirolimus 0 1
Cyclophosphamide + Methotrexate + Sirolimus + Zoledronic acid Cyclophosphamide Methotrexate Sirolimus Zoledronic acid 0 1
Cyclophosphamide + Sirolimus Cyclophosphamide Sirolimus 0 1
Cyclophosphamide + Sirolimus + Topotecan Cyclophosphamide Sirolimus Topotecan 0 1
Cyclosporine + Fludarabine + Mycophenolate mofetil + Sirolimus Cyclosporine Fludarabine Mycophenolate mofetil Sirolimus 0 1
Cyclosporine + Mycophenolate mofetil + Sirolimus Cyclosporine Mycophenolate mofetil Sirolimus 0 1
Cytarabine + Etoposide + Mitoxantrone + Sirolimus Cytarabine Etoposide Mitoxantrone Sirolimus 0 1
Cytarabine + Idarubicin + Sirolimus Cytarabine Idarubicin Sirolimus 0 1
Dasatinib + Irinotecan + Sirolimus + Temozolomide Dasatinib Irinotecan Sirolimus Temozolomide 0 1
Dasatinib + Sirolimus Dasatinib Sirolimus 0 0
Decitabine + Sirolimus Decitabine Sirolimus 0 1
Denileukin diftitox + Sirolimus Denileukin diftitox Sirolimus 0 0
Doxorubicin + Sirolimus Doxorubicin Sirolimus 0 0
Durvalumab + Sirolimus Durvalumab Sirolimus 0 1
Ensartinib + Sirolimus Ensartinib Sirolimus 1 0
Epacadostat + Sirolimus Epacadostat Sirolimus 0 1
Erlotinib + Sirolimus Erlotinib Sirolimus 0 1
Fulvestrant + Lapatinib + Sirolimus Fulvestrant Lapatinib Sirolimus 0 0
Ganetespib + Sirolimus Ganetespib Sirolimus 0 1
Gemcitabine + Sirolimus Gemcitabine Sirolimus 0 0
GSK690693 + Sirolimus GSK690693 Sirolimus 1 0
H3B-5942 + Sirolimus H3B-5942 Sirolimus 0 0
Hydroxychloroquine + Sirolimus Hydroxychloroquine Sirolimus 0 1
Ipatasertib + Sirolimus Ipatasertib Sirolimus 1 0
Ipilimumab + Nivolumab + Prednisone + Sirolimus Ipilimumab Nivolumab Prednisone Sirolimus 0 1
Irinotecan + Sirolimus + Sunitinib + Temozolomide Irinotecan Sirolimus Sunitinib Temozolomide 0 0
JX-594 + Sirolimus JX-594 Sirolimus 0 0
Lapatinib + Sirolimus Lapatinib Sirolimus 0 1
Luminespib + Sirolimus Luminespib Sirolimus 0 0
LY294002 + Sirolimus LY294002 Sirolimus 0 0
MEDI-573 + Sirolimus MEDI-573 Sirolimus 0 0
Melanin + Phenytoin + Sirolimus + SM88 Melanin Phenytoin SM88 Sirolimus 0 0
Metformin + Sirolimus Metformin Sirolimus 0 2
Methotrexate + Sirolimus Methotrexate Sirolimus 0 1
Methotrexate + Sirolimus + Tacrolimus Methotrexate Sirolimus Tacrolimus 0 3
Methoxsalen + Phenytoin + Sirolimus + SM88 Methoxsalen Phenytoin SM88 Sirolimus 0 3
Miransertib + Sirolimus Miransertib Sirolimus 1 0
MK2206 + Sirolimus MK2206 Sirolimus 1 0
NY-ESO-1 peptide vaccine + Sirolimus NY-ESO-1 peptide vaccine Sirolimus 0 1
Osimertinib + Sirolimus Osimertinib Sirolimus 0 0
Palbociclib + Sirolimus Palbociclib Sirolimus 1 0
Pemetrexed Disodium + Sirolimus Pemetrexed Disodium Sirolimus 0 0
Pexidartinib + Sirolimus Pexidartinib Sirolimus 0 1
RU-SKI 43 + Sirolimus RU-SKI 43 Sirolimus 0 0
Ruxolitinib + Sirolimus + Tacrolimus Ruxolitinib Sirolimus Tacrolimus 0 1
Sapanisertib + Sirolimus Sapanisertib Sirolimus 0 0
SBI-0206965 + Sirolimus SBI-0206965 Sirolimus 0 0
Selumetinib + Sirolimus Selumetinib Sirolimus 0 1
Sirolimus Sirolimus 22 33
Sirolimus + Tamoxifen Sirolimus Tamoxifen 0 0
Sirolimus + Trametinib Sirolimus Trametinib 2 0
Sirolimus + Trastuzumab Sirolimus Trastuzumab 0 1
Sirolimus + unspecified PD-1 antibody Sirolimus unspecified PD-1 antibody 0 0
Sirolimus + Vismodegib Sirolimus Vismodegib 0 1
Sirolimus + Vorinostat Sirolimus Vorinostat 0 0
Sirolimus + WEHI-539 Sirolimus WEHI-539 0 0


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