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Drug Name WEHI-539
Trade Name
Drug Descriptions

WEHI-539 is a selective inhibitor of BCL-XL that stimulates apoptotic responses in cells, resulting in killing of tumor cells (PMID: 23603658, PMID: 32752193).

DrugClasses BCL-XL inhibitor 14
CAS Registry Number 1431866-33-9


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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Lapatinib + WEHI-539 A-1210477 Lapatinib WEHI-539 0 0
A-1210477 + WEHI-539 A-1210477 WEHI-539 1 0
Alpelisib + WEHI-539 Alpelisib WEHI-539 1 0
Buparlisib + WEHI-539 Buparlisib WEHI-539 1 0
Dactolisib + WEHI-539 Dactolisib WEHI-539 5 0
G-TPP + WEHI-539 G-TPP WEHI-539 0 0
Sapanisertib + WEHI-539 Sapanisertib WEHI-539 1 0
Sirolimus + WEHI-539 Sirolimus WEHI-539 0 0
Torin 1 + WEHI-539 Torin 1 WEHI-539 1 0
Vistusertib + WEHI-539 Vistusertib WEHI-539 1 0
VX-11e + WEHI-539 VX-11e WEHI-539 1 0
WEHI-539 WEHI-539 0 0

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