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Drug Name VX-11e
Trade Name
Synonyms VX11e|VX 11e|VTX-11e|VRT-11E|VRT11E
Drug Descriptions

VX-11e is an ATP-competitive inhibitor of Mapk1 (Erk2) and Mapk3 (Erk1), which may result in growth inhibition and tumor regression (PMID: 19827834, PMID: 24265153, PMID: 31935908).

DrugClasses ERK Inhibitor (pan) 21
CAS Registry Number 896720-20-0


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AZ628 + VX-11e AZ628 VX-11e 0 0
Fulvestrant + VX-11e Fulvestrant VX-11e 0 0
Venetoclax + VX-11e VX-11e Venetoclax 1 0
VX-11e VX-11e 6 0
VX-11e + WEHI-539 VX-11e WEHI-539 1 0

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