Drug Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Trastuzumab
Trade Name Herceptin
Synonyms Anti HER2
Drug Descriptions

Herceptin (trastuzumab) is a monoclonal antibody, which binds ERBB2 (HER2) to induce tumor cellular cytotoxicity (PMID: 17611206). Herceptin (trastuzumab) is FDA approved for HER2-overexpressing (or amplification) breast cancer, gastric adenocarcinoma, and gastroesophageal junction adenocarcinoma (FDA.gov).

DrugClasses HER2 (ERBB2) Antibody 38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
212Pb-TCMC-Trastuzumab + Trastuzumab 212Pb-TCMC-Trastuzumab Trastuzumab 0 1
2B3-101 + Trastuzumab 2B3-101 Trastuzumab 0 1
Abemaciclib + Fulvestrant + Trastuzumab Abemaciclib Fulvestrant Trastuzumab 1 1
Abemaciclib + Loperamide + Pertuzumab + Trastuzumab Abemaciclib Loperamide Pertuzumab Trastuzumab 0 1
Abemaciclib + Trastuzumab Abemaciclib Trastuzumab 1 2
Abemaciclib + Trastuzumab + Tucatinib Abemaciclib Trastuzumab Tucatinib 0 1
ACTR087 + Trastuzumab ACTR087 Trastuzumab 0 1
ACTR707 + Trastuzumab ACTR707 Trastuzumab 0 1
Ado-trastuzumab emtansine + Trastuzumab Ado-trastuzumab emtansine Trastuzumab 0 1
Afatinib + Trastuzumab Afatinib Trastuzumab 5 0
Aldoxorubicin + ALT-803 + Avelumab + Capecitabine + Cetuximab + Cyclophosphamide + ETBX-011 + ETBX-021 + ETBX-051 + ETBX-061 + Fluorouracil + GI-4000 + GI-6207 + GI-6301 + haNK cells + Leucovorin + Nab-paclitaxel + Oxaliplatin + Regorafenib + Trastuzumab ALT-803 Aldoxorubicin Avelumab Capecitabine Cetuximab Cyclophosphamide ETBX-011 ETBX-021 ETBX-051 ETBX-061 Fluorouracil GI-4000 GI-6207 GI-6301 Leucovorin Nab-paclitaxel Oxaliplatin Regorafenib Trastuzumab haNK cells 0 1
Alpelisib + Elgemtumab + Trastuzumab Alpelisib Elgemtumab Trastuzumab 0 1
Alpelisib + Pertuzumab + Trastuzumab Alpelisib Pertuzumab Trastuzumab 0 1
alpha-TEA + Trastuzumab Trastuzumab alpha-TEA 0 1
ALX148 + Trastuzumab ALX148 Trastuzumab 2 1
Anastrozole + Carboplatin + Docetaxel + Pertuzumab + Trastuzumab Anastrozole Carboplatin Docetaxel Pertuzumab Trastuzumab 0 0
Anastrozole + Carboplatin + Docetaxel + Trastuzumab Anastrozole Carboplatin Docetaxel Trastuzumab 0 0
Anastrozole + Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Trastuzumab Anastrozole Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Trastuzumab 0 0
Anastrozole + Cyclophosphamide + Doxorubicin + Paclitaxel + Trastuzumab Anastrozole Cyclophosphamide Doxorubicin Paclitaxel Trastuzumab 0 0
Anastrozole + Lapatinib + Trastuzumab Anastrozole Lapatinib Trastuzumab 0 0
Anastrozole + Palbociclib + Pertuzumab + Trastuzumab Anastrozole Palbociclib Pertuzumab Trastuzumab 0 1
Anastrozole + Trastuzumab Anastrozole Trastuzumab 0 0
Atezolizumab + Paclitaxel + Pertuzumab + Trastuzumab Atezolizumab Paclitaxel Pertuzumab Trastuzumab 0 2
Atezolizumab + Pertuzumab + Trastuzumab Atezolizumab Pertuzumab Trastuzumab 0 2
Atezolizumab + Trastuzumab Atezolizumab Trastuzumab 0 2
Avelumab + Fluorouracil + Leucovorin + Oxaliplatin + Trastuzumab Avelumab Fluorouracil Leucovorin Oxaliplatin Trastuzumab 0 1
Avelumab + Trastuzumab Avelumab Trastuzumab 0 1
Avelumab + Trastuzumab + Utomilumab Avelumab Trastuzumab Utomilumab 0 1
Avelumab + Trastuzumab + Utomilumab + Vinorelbine Avelumab Trastuzumab Utomilumab Vinorelbine 0 1
Avelumab + Trastuzumab + Vinorelbine Avelumab Trastuzumab Vinorelbine 0 1
Bevacizumab + Capecitabine + Oxaliplatin + Trastuzumab Bevacizumab Capecitabine Oxaliplatin Trastuzumab 0 0
Bevacizumab + Trastuzumab Bevacizumab Trastuzumab 0 1
Buparlisib + Capecitabine + Trastuzumab Buparlisib Capecitabine Trastuzumab 0 1
Buparlisib + Lapatinib + Trastuzumab Buparlisib Lapatinib Trastuzumab 1 0
Buparlisib + Pertuzumab + Trastuzumab Buparlisib Pertuzumab Trastuzumab 1 0
Buparlisib + Trastuzumab Buparlisib Trastuzumab 3 0
Capecitabine + Cisplatin + Fluorouracil + Trastuzumab Capecitabine Cisplatin Fluorouracil Trastuzumab 0 1
Capecitabine + Cisplatin + Pembrolizumab + Trastuzumab Capecitabine Cisplatin Pembrolizumab Trastuzumab 0 1
Capecitabine + Cisplatin + Pertuzumab + Trastuzumab Capecitabine Cisplatin Pertuzumab Trastuzumab 0 0
Capecitabine + Cisplatin + Trastuzumab Capecitabine Cisplatin Trastuzumab 0 2
Capecitabine + Cyclophosphamide + Lapatinib + Trastuzumab Capecitabine Cyclophosphamide Lapatinib Trastuzumab 0 1
Capecitabine + Oxaliplatin + Pembrolizumab + Trastuzumab Capecitabine Oxaliplatin Pembrolizumab Trastuzumab 0 1
Capecitabine + Oxaliplatin + Trastuzumab Capecitabine Oxaliplatin Trastuzumab 0 3
Capecitabine + Trastuzumab Capecitabine Trastuzumab 4 4
Capecitabine + Trastuzumab + Tucatinib Capecitabine Trastuzumab Tucatinib 5 3
Carboplatin + Docetaxel + Exemestane + Pertuzumab + Trastuzumab Carboplatin Docetaxel Exemestane Pertuzumab Trastuzumab 0 0
Carboplatin + Docetaxel + Exemestane + Trastuzumab Carboplatin Docetaxel Exemestane Trastuzumab 0 0
Carboplatin + Docetaxel + Goserelin + Pertuzumab + Trastuzumab Carboplatin Docetaxel Goserelin Pertuzumab Trastuzumab 0 1
Carboplatin + Docetaxel + Letrozole + Pertuzumab + Trastuzumab Carboplatin Docetaxel Letrozole Pertuzumab Trastuzumab 0 0
Carboplatin + Docetaxel + Letrozole + Trastuzumab Carboplatin Docetaxel Letrozole Trastuzumab 0 0
Carboplatin + Docetaxel + Metformin + Pertuzumab + Trastuzumab Carboplatin Docetaxel Metformin Pertuzumab Trastuzumab 0 1
Carboplatin + Docetaxel + Pertuzumab + Tamoxifen + Trastuzumab Carboplatin Docetaxel Pertuzumab Tamoxifen Trastuzumab 0 0
Carboplatin + Docetaxel + Pertuzumab + Trastuzumab Carboplatin Docetaxel Pertuzumab Trastuzumab 1 3
Carboplatin + Docetaxel + Tamoxifen + Trastuzumab Carboplatin Docetaxel Tamoxifen Trastuzumab 0 0
Carboplatin + Docetaxel + Trastuzumab Carboplatin Docetaxel Trastuzumab 1 3
Carboplatin + Nab-paclitaxel + Trastuzumab Carboplatin Nab-paclitaxel Trastuzumab 0 1
Carboplatin + Paclitaxel + Pertuzumab + Trastuzumab Carboplatin Paclitaxel Pertuzumab Trastuzumab 0 1
Carboplatin + Paclitaxel + Trastuzumab Carboplatin Paclitaxel Trastuzumab 4 1
Carboplatin + Pembrolizumab + Trastuzumab Carboplatin Pembrolizumab Trastuzumab 0 1
Carboplatin + Trastuzumab Carboplatin Trastuzumab 0 1
CDX-3379 + Trastuzumab CDX-3379 Trastuzumab 1 1
Cetuximab + Trastuzumab Cetuximab Trastuzumab 0 0
CH5132799 + Fulvestrant + Trastuzumab CH5132799 Fulvestrant Trastuzumab 0 1
CH5132799 + Trastuzumab CH5132799 Trastuzumab 1 1
Cisplatin + Fluorouracil + Pembrolizumab + Trastuzumab Cisplatin Fluorouracil Pembrolizumab Trastuzumab 0 1
Cisplatin + Fluorouracil + Trastuzumab Cisplatin Fluorouracil Trastuzumab 0 2
Copanlisib + Pertuzumab + Trastuzumab Copanlisib Pertuzumab Trastuzumab 0 1
Crizotinib + Paclitaxel + Trastuzumab Crizotinib Paclitaxel Trastuzumab 0 0
Cyclophosphamide + Docetaxel + Doxorubicin + Epirubicin + Fluorouracil + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Docetaxel Doxorubicin Epirubicin Fluorouracil Paclitaxel Pertuzumab Trastuzumab 0 1
Cyclophosphamide + Docetaxel + Epirubicin + Fluorouracil + Pertuzumab + Trastuzumab Cyclophosphamide Docetaxel Epirubicin Fluorouracil Pertuzumab Trastuzumab 0 1
Cyclophosphamide + Docetaxel + Trastuzumab Cyclophosphamide Docetaxel Trastuzumab 0 1
Cyclophosphamide + Doxorubicin + Epirubicin + Fluorouracil + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Epirubicin Fluorouracil Pertuzumab Trastuzumab 0 1
Cyclophosphamide + Doxorubicin + Exemestane + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Exemestane Paclitaxel Pertuzumab Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Exemestane + Paclitaxel + Trastuzumab Cyclophosphamide Doxorubicin Exemestane Paclitaxel Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Letrozole + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Letrozole Paclitaxel Pertuzumab Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Letrozole + Paclitaxel + Trastuzumab Cyclophosphamide Doxorubicin Letrozole Paclitaxel Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Neratinib + Paclitaxel + Trastuzumab Cyclophosphamide Doxorubicin Neratinib Paclitaxel Trastuzumab 0 1
Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Tamoxifen + Trastuzumab Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Tamoxifen Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Trastuzumab 1 3
Cyclophosphamide + Doxorubicin + Paclitaxel + Tamoxifen + Trastuzumab Cyclophosphamide Doxorubicin Paclitaxel Tamoxifen Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Paclitaxel + Trastuzumab Cyclophosphamide Doxorubicin Paclitaxel Trastuzumab 1 2
Cyclophosphamide + Doxorubicin + Pertuzumab + Tamoxifen + Trastuzumab Cyclophosphamide Doxorubicin Pertuzumab Tamoxifen Trastuzumab 0 0
Cyclophosphamide + Epirubicin + Fluorouracil + Pertuzumab + Trastuzumab Cyclophosphamide Epirubicin Fluorouracil Pertuzumab Trastuzumab 0 1
Cyclophosphamide + Epirubicin + Paclitaxel + Trastuzumab Cyclophosphamide Epirubicin Paclitaxel Trastuzumab 0 1
Cyclophosphamide + Paclitaxel + Trastuzumab Cyclophosphamide Paclitaxel Trastuzumab 0 1
Dasatinib + Trastuzumab Dasatinib Trastuzumab 0 0
Docetaxel + Lapatinib + Trastuzumab Docetaxel Lapatinib Trastuzumab 0 0
Docetaxel + Nivolumab + Pertuzumab + Trastuzumab Docetaxel Nivolumab Pertuzumab Trastuzumab 0 1
Docetaxel + Paclitaxel + Pegfilgrastim + Pertuzumab + Trastuzumab Docetaxel Paclitaxel Pegfilgrastim Pertuzumab Trastuzumab 0 1
Docetaxel + Pertuzumab + Trastuzumab Docetaxel Pertuzumab Trastuzumab 4 5
Docetaxel + Trastuzumab Docetaxel Trastuzumab 3 0
Durvalumab + Pertuzumab + Trastuzumab Durvalumab Pertuzumab Trastuzumab 0 1
Durvalumab + Trastuzumab Durvalumab Trastuzumab 0 1
Elgemtumab + Trastuzumab Elgemtumab Trastuzumab 1 1
Entinostat + Lapatinib + Trastuzumab Entinostat Lapatinib Trastuzumab 2 1
Enzalutamide + Trastuzumab Enzalutamide Trastuzumab 0 1
Epertinib + Trastuzumab Epertinib Trastuzumab 1 0
Eribulin + Trastuzumab Eribulin Trastuzumab 0 2
Erlotinib + Fluorouracil + Leucovorin + Nab-paclitaxel + Trastuzumab Erlotinib Fluorouracil Leucovorin Nab-paclitaxel Trastuzumab 0 0
Erlotinib + Trastuzumab Erlotinib Trastuzumab 0 0
Everolimus + Letrozole + Trastuzumab Everolimus Letrozole Trastuzumab 0 1
Everolimus + Trastuzumab Everolimus Trastuzumab 0 0
Everolimus + Trastuzumab + Vinorelbine Everolimus Trastuzumab Vinorelbine 1 1
Exemestane + Lapatinib + Trastuzumab Exemestane Lapatinib Trastuzumab 0 0
Exemestane + Pertuzumab + Trastuzumab Exemestane Pertuzumab Trastuzumab 0 0
Exemestane + Trastuzumab Exemestane Trastuzumab 0 0
FATE-NK100 + Trastuzumab FATE-NK100 Trastuzumab 0 1
Fluorouracil + Leucovorin + Oxaliplatin + Trastuzumab Fluorouracil Leucovorin Oxaliplatin Trastuzumab 1 1
Fluorouracil + Leucovorin + Trastuzumab Fluorouracil Leucovorin Trastuzumab 1 0
Fluorouracil + MM-398 + Oxaliplatin + Trastuzumab Fluorouracil MM-398 Oxaliplatin Trastuzumab 0 1
Fluorouracil + Oxaliplatin + Trastuzumab Fluorouracil Oxaliplatin Trastuzumab 1 1
Fulvestrant + Neratinib + Trastuzumab Fulvestrant Neratinib Trastuzumab 0 2
Fulvestrant + Pertuzumab + Trastuzumab Fulvestrant Pertuzumab Trastuzumab 0 0
Fulvestrant + Trastuzumab Fulvestrant Trastuzumab 0 0
Ganetespib + Paclitaxel + Trastuzumab Ganetespib Paclitaxel Trastuzumab 0 1
GDC-0084 + Trastuzumab GDC-0084 Trastuzumab 0 1
Gemcitabine + Pertuzumab + Trastuzumab Gemcitabine Pertuzumab Trastuzumab 0 2
Gemcitabine + Trastuzumab Gemcitabine Trastuzumab 0 1
HER-2/neu intracellular domain protein + Pertuzumab + Polysaccharide-K + Trastuzumab HER-2/neu intracellular domain protein Pertuzumab Polysaccharide-K Trastuzumab 0 1
HER-2/neu intracellular domain protein + Pertuzumab + Trastuzumab HER-2/neu intracellular domain protein Pertuzumab Trastuzumab 0 1
HER-2/neu intracellular domain protein + Polysaccharide-K + Trastuzumab HER-2/neu intracellular domain protein Polysaccharide-K Trastuzumab 0 0
HER-2/neu intracellular domain protein + Trastuzumab HER-2/neu intracellular domain protein Trastuzumab 0 0
Ibrutinib + Trastuzumab Ibrutinib Trastuzumab 0 1
interferon gamma + Paclitaxel + Pertuzumab + Trastuzumab Paclitaxel Pertuzumab Trastuzumab interferon gamma 0 1
Ladiratuzumab vedotin + Trastuzumab Ladiratuzumab vedotin Trastuzumab 0 1
Lapatinib + Letrozole + Trastuzumab Lapatinib Letrozole Trastuzumab 0 0
Lapatinib + Paclitaxel + Trastuzumab Lapatinib Paclitaxel Trastuzumab 1 0
Lapatinib + Trastuzumab Lapatinib Trastuzumab 17 7
Letrozole + Palbociclib + Trastuzumab Letrozole Palbociclib Trastuzumab 0 1
Letrozole + Trastuzumab Letrozole Trastuzumab 0 0
Linsitinib + Temsirolimus + Trastuzumab Linsitinib Temsirolimus Trastuzumab 0 0
Miransertib + Trastuzumab Miransertib Trastuzumab 1 0
MK2206 + Trastuzumab MK2206 Trastuzumab 1 1
MM-111 + Paclitaxel + Trastuzumab MM-111 Paclitaxel Trastuzumab 2 1
MM-302 + Trastuzumab MM-302 Trastuzumab 2 1
Nab-paclitaxel + Pertuzumab + Trastuzumab Nab-paclitaxel Pertuzumab Trastuzumab 0 1
Necitumumab + Osimertinib + Trastuzumab Necitumumab Osimertinib Trastuzumab 0 1
Neratinib + Paclitaxel + Pertuzumab + Trastuzumab Neratinib Paclitaxel Pertuzumab Trastuzumab 0 2
Neratinib + Trastuzumab Neratinib Trastuzumab 3 4
Niraparib + Trastuzumab Niraparib Trastuzumab 0 1
Oxaliplatin + Pembrolizumab + Tegafur-gimeracil-oteracil Potassium + Trastuzumab Oxaliplatin Pembrolizumab Tegafur-gimeracil-oteracil Potassium Trastuzumab 0 1
Oxaliplatin + Tegafur-gimeracil-oteracil Potassium + Trastuzumab Oxaliplatin Tegafur-gimeracil-oteracil Potassium Trastuzumab 1 1
Oxaliplatin + Trastuzumab Oxaliplatin Trastuzumab 2 0
Paclitaxel + Pembrolizumab + Pertuzumab + Trastuzumab Paclitaxel Pembrolizumab Pertuzumab Trastuzumab 0 2
Paclitaxel + Pembrolizumab + Trastuzumab Paclitaxel Pembrolizumab Trastuzumab 0 1
Paclitaxel + Pertuzumab + pUMVC3-IGFBP2-HER2-IGF1R vaccine + Trastuzumab Paclitaxel Pertuzumab Trastuzumab pUMVC3-IGFBP2-HER2-IGF1R vaccine 0 1
Paclitaxel + Pertuzumab + Trastuzumab Paclitaxel Pertuzumab Trastuzumab 2 11
Paclitaxel + Trastuzumab Paclitaxel Trastuzumab 0 6
Paclitaxel + Trastuzumab + TVB-2640 Paclitaxel TVB-2640 Trastuzumab 0 1
Palbociclib + Trastuzumab Palbociclib Trastuzumab 1 0
Pembrolizumab + Trastuzumab Pembrolizumab Trastuzumab 0 1
Pemigatinib + Trastuzumab Pemigatinib Trastuzumab 0 1
Pertuzumab + Tocilizumab + Trastuzumab Pertuzumab Tocilizumab Trastuzumab 0 1
Pertuzumab + Trastuzumab Pertuzumab Trastuzumab 32 27
Pertuzumab + Trastuzumab + Vinorelbine Pertuzumab Trastuzumab Vinorelbine 0 1
Ramucirumab + Trastuzumab Ramucirumab Trastuzumab 0 1
Ruxolitinib + Trastuzumab Ruxolitinib Trastuzumab 0 1
S63845 + Trastuzumab S63845 Trastuzumab 1 0
Sargramostim + TPIV100 + Trastuzumab Sargramostim TPIV100 Trastuzumab 0 0
Sargramostim + Trastuzumab Sargramostim Trastuzumab 0 1
Sirolimus + Trastuzumab Sirolimus Trastuzumab 0 1
Sunitinib + Trastuzumab Sunitinib Trastuzumab 1 0
Tamoxifen + Trastuzumab Tamoxifen Trastuzumab 0 0
Temsirolimus + Trastuzumab Temsirolimus Trastuzumab 0 0
Tesevatinib + Trastuzumab Tesevatinib Trastuzumab 0 1
Trastuzumab Trastuzumab 55 39
Trastuzumab + Trebananib Trastuzumab Trebananib 0 1
Trastuzumab + Tretinoin Trastuzumab Tretinoin 0 0
Trastuzumab + Tucatinib Trastuzumab Tucatinib 1 3
Trastuzumab + Utomilumab Trastuzumab Utomilumab 0 1
Trastuzumab + Varlitinib Trastuzumab Varlitinib 1 0
Trastuzumab + Vinorelbine Trastuzumab Vinorelbine 8 3
Trastuzumab + Vinorelbine + Zenocutuzumab Trastuzumab Vinorelbine Zenocutuzumab 0 1
Trastuzumab + XL147 Trastuzumab XL147 1 0
Trastuzumab + Zenocutuzumab Trastuzumab Zenocutuzumab 0 1


Additional content available in CKB BOOST