Drug Detail


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Drug Name Pemigatinib
Trade Name Pemazyre
Synonyms INCB54828|INCB054828
Drug Descriptions

Pemazyre (pemigatinib) is a fibroblast growth factor receptor (FGFR) inhibitor that blocks FGFR1/2/3 signaling, which results in growth inhibition in tumor cells (PMID: 32203698). Pemazyre (pemigatinib) is FDA approved for use in patients with advanced or metastatic cholangiocarcinoma harboring FGFR2 fusion or rearrangement (FDA.gov).

DrugClasses FGFR1 Inhibitor 24 FGFR2 Inhibitor 18 FGFR3 Inhibitor 13
CAS Registry Number 1513857-77-6
NCIT ID C121553


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + Gemcitabine + Pemigatinib Cisplatin Gemcitabine Pemigatinib 0 2
Cytarabine + Daunorubicin + Pemigatinib Cytarabine Daunorubicin Pemigatinib 0 1
Cytarabine + Pemigatinib Cytarabine Pemigatinib 0 1
Docetaxel + Pemigatinib Docetaxel Pemigatinib 0 1
INCB054329 + Pemigatinib INCB054329 Pemigatinib 0 0
Pembrolizumab + Pemigatinib Pembrolizumab Pemigatinib 0 2
Pemigatinib Pemigatinib 134 15
Pemigatinib + Retifanlimab Pemigatinib Retifanlimab 0 3
Pemigatinib + Trastuzumab Pemigatinib Trastuzumab 0 1

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