Drug Detail


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Drug Name Pemigatinib
Trade Name Pemazyre
Synonyms INCB54828|INCB054828
Drug Descriptions

Pemazyre (pemigatinib) is a fibroblast growth factor receptor (FGFR) inhibitor that blocks FGFR1/2/3 signaling, which results in growth inhibition in tumor cells (PMID: 32203698). Pemazyre (pemigatinib) is FDA approved for use in patients with advanced or metastatic cholangiocarcinoma harboring FGFR2 fusion or rearrangement (FDA.gov).

DrugClasses FGFR1 Inhibitor 23 FGFR2 Inhibitor 16 FGFR3 Inhibitor 13


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + Gemcitabine + Pemigatinib Cisplatin Gemcitabine Pemigatinib 0 2
Docetaxel + Pemigatinib Docetaxel Pemigatinib 0 1
INCB054329 + Pemigatinib INCB054329 Pemigatinib 1 0
Pembrolizumab + Pemigatinib Pembrolizumab Pemigatinib 0 1
Pemigatinib Pemigatinib 13 9
Pemigatinib + Retifanlimab Pemigatinib Retifanlimab 0 1
Pemigatinib + Trastuzumab Pemigatinib Trastuzumab 0 1

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