Drug Detail


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Drug Name Pemigatinib
Trade Name Pemazyre
Synonyms INCB54828|INCB054828
Drug Descriptions

Pemazyre (pemigatinib) is a fibroblast growth factor receptor (FGFR) inhibitor that blocks FGFR1/2/3 signaling, which results in growth inhibition in tumor cells (PMID: 32203698). Pemazyre (pemigatinib) is FDA approved for use in patients with advanced or metastatic cholangiocarcinoma harboring FGFR2 fusion or rearrangement, and in adult patients with relapsed or refractory myeloid or lymphoid neoplasms harboring FGFR1 rearrangement (FDA.gov).

DrugClasses FGFR1 Inhibitor 28 FGFR2 Inhibitor 22 FGFR3 Inhibitor 19
CAS Registry Number 1513857-77-6
NCIT ID C121553


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cisplatin + Gemcitabine + Pemigatinib Cisplatin Gemcitabine Pemigatinib 0 2
Cytarabine + Daunorubicin + Pemigatinib Cytarabine Daunorubicin Pemigatinib 0 1
Cytarabine + Pemigatinib Cytarabine Pemigatinib 0 1
Docetaxel + Pemigatinib Docetaxel Pemigatinib 0 1
Gemcitabine + Oxaliplatin + Pembrolizumab + Pemigatinib Gemcitabine Oxaliplatin Pembrolizumab Pemigatinib 0 0
Gemcitabine + Pemigatinib Gemcitabine Pemigatinib 0 0
INCB054329 + Pemigatinib INCB054329 Pemigatinib 0 0
Panobinostat + Pemigatinib Panobinostat Pemigatinib 0 0
Pembrolizumab + Pemigatinib Pembrolizumab Pemigatinib 0 2
Pemigatinib Pemigatinib 130 16
Pemigatinib + Quisinostat Pemigatinib Quisinostat 0 0
Pemigatinib + Retifanlimab Pemigatinib Retifanlimab 0 3
Pemigatinib + Trastuzumab Pemigatinib Trastuzumab 0 1
Pemigatinib + unspecified KRAS G12C inhibitor Pemigatinib unspecified KRAS G12C inhibitor 0 0

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