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Drug Name Retifanlimab
Trade Name Zynyz
Synonyms MGA 012|INCMGA00012|MGA012|retifanlimab-dlwr
Drug Descriptions

Zynyz (retifanlimab) is a humanized IgG4 monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT085). Zynyz (retifanlimab) is FDA approved for use in adult patients with metastatic or recurrent locally advanced Merkel cell carcinoma (FDA.gov).

DrugClasses Immune Checkpoint Inhibitor 147 PD-L1/PD-1 antibody 117
CAS Registry Number 2226345-85-1
NCIT ID C142168

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Epacadostat + Radiotherapy + Retifanlimab Bevacizumab Epacadostat Radiotherapy Retifanlimab 0 1
Bevacizumab + Radiotherapy + Retifanlimab Bevacizumab Radiotherapy Retifanlimab 0 1
Bevacizumab + Retifanlimab Bevacizumab Retifanlimab 0 1
Capecitabine + Margetuximab-cmkb + Oxaliplatin + Retifanlimab Capecitabine Margetuximab-cmkb Oxaliplatin Retifanlimab 0 1
Capecitabine + Oxaliplatin + Retifanlimab Capecitabine Oxaliplatin Retifanlimab 0 1
Carboplatin + Nab-paclitaxel + Retifanlimab Carboplatin Nab-paclitaxel Retifanlimab 0 1
Carboplatin + Paclitaxel + Retifanlimab Carboplatin Paclitaxel Retifanlimab 0 3
Carboplatin + Pemetrexed Disodium + Retifanlimab Carboplatin Pemetrexed Disodium Retifanlimab 0 2
Cetuximab + INCB161734 + Retifanlimab Cetuximab INCB161734 Retifanlimab 0 1
Cisplatin + Etoposide + Retifanlimab Cisplatin Etoposide Retifanlimab 0 1
Cisplatin + Gemcitabine + Retifanlimab Cisplatin Gemcitabine Retifanlimab 0 1
Cisplatin + Pemetrexed Disodium + Retifanlimab Cisplatin Pemetrexed Disodium Retifanlimab 0 2
Cyclophosphamide + Doxorubicin + Prednisone + Retifanlimab + Rituximab + Tafasitamab-cxix + Vincristine Sulfate Cyclophosphamide Doxorubicin Prednisone Retifanlimab Rituximab Tafasitamab-cxix Vincristine Sulfate 0 1
Cyclophosphamide + Peg-interferon alfa-2a + Retifanlimab + SV-BR-1-GM Cyclophosphamide Peg-interferon alfa-2a Retifanlimab SV-BR-1-GM 0 1
Cyclophosphamide + Retifanlimab + SV-BR-1-GM Cyclophosphamide Retifanlimab SV-BR-1-GM 0 0
Docetaxel + Gemcitabine + Retifanlimab Docetaxel Gemcitabine Retifanlimab 0 1
Doxorubicin + Ifosfamide + Retifanlimab Doxorubicin Ifosfamide Retifanlimab 0 1
DPV-001 + INCAGN01876 + Retifanlimab DPV-001 INCAGN01876 Retifanlimab 0 1
DPV-001 + INCAGN01949 + Retifanlimab DPV-001 INCAGN01949 Retifanlimab 0 0
DPV-001 + Retifanlimab DPV-001 Retifanlimab 0 1
Elraglusib + Gemcitabine + Nab-paclitaxel + Retifanlimab Elraglusib Gemcitabine Nab-paclitaxel Retifanlimab 0 1
Epacadostat + Retifanlimab Epacadostat Retifanlimab 0 3
ETBX-011 + ETBX-051 + ETBX-061 + Nogapendekin alfa inbakicept + Retifanlimab ETBX-011 ETBX-051 ETBX-061 Nogapendekin alfa inbakicept Retifanlimab 0 1
ETBX-011 + ETBX-051 + ETBX-061 + Nogapendekin alfa inbakicept + Retifanlimab + SX-682 ETBX-011 ETBX-051 ETBX-061 Nogapendekin alfa inbakicept Retifanlimab SX-682 0 1
Fluorouracil + Leucovorin + Margetuximab-cmkb + Oxaliplatin + Retifanlimab Fluorouracil Leucovorin Margetuximab-cmkb Oxaliplatin Retifanlimab 0 1
INCA00186 + INCB106385 + Retifanlimab INCA00186 INCB106385 Retifanlimab 0 1
INCA00186 + Retifanlimab INCA00186 Retifanlimab 0 1
INCAGN01876 + Retifanlimab INCAGN01876 Retifanlimab 0 2
INCAGN02385 + INCAGN02390 + Retifanlimab INCAGN02385 INCAGN02390 Retifanlimab 0 4
INCAGN02385 + Retifanlimab INCAGN02385 Retifanlimab 0 1
INCB106385 + Retifanlimab INCB106385 Retifanlimab 0 1
Margetuximab-cmkb + Retifanlimab Margetuximab-cmkb Retifanlimab 0 1
MGA271 + Retifanlimab MGA271 Retifanlimab 0 1
MGC018 + Retifanlimab MGC018 Retifanlimab 0 1
MGD007 + Retifanlimab MGD007 Retifanlimab 0 1
Neoantigen peptide vaccine + Poly ICLC + Retifanlimab Neoantigen peptide vaccine Poly ICLC Retifanlimab 0 1
Obrindatamab + Retifanlimab Obrindatamab Retifanlimab 0 1
Paclitaxel + Retifanlimab + SNDX-6352 Paclitaxel Retifanlimab SNDX-6352 0 1
Palbociclib + Retifanlimab Palbociclib Retifanlimab 0 1
Parsaclisib + Retifanlimab Parsaclisib Retifanlimab 0 1
Pelareorep + Retifanlimab Pelareorep Retifanlimab 0 1
Pemetrexed Disodium + Retifanlimab Pemetrexed Disodium Retifanlimab 0 1
Pemigatinib + Retifanlimab Pemigatinib Retifanlimab 0 3
Personalized cancer vaccine + Retifanlimab Personalized cancer vaccine Retifanlimab 0 1
Retifanlimab Retifanlimab 0 10
Retifanlimab + Ruxolitinib + Trametinib Retifanlimab Ruxolitinib Trametinib 0 1
Retifanlimab + Telotristat etiprate Retifanlimab Telotristat etiprate 0 1
Retifanlimab + Temozolomide Retifanlimab Temozolomide 0 1
Retifanlimab + Tretinoin Retifanlimab Tretinoin 0 1


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