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Drug Name INCMGA00012
Trade Name
Synonyms MGA 012
Drug Descriptions

INCMGA00012 is a humanized IgG4 monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT085).

DrugClasses Immune Checkpoint Inhibitor 95 PD-L1/PD-1 antibody 63

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Capecitabine + INCMGA00012 + Margetuximab + Oxaliplatin Capecitabine INCMGA00012 Margetuximab Oxaliplatin 0 1
Carboplatin + INCMGA00012 + Nab-paclitaxel Carboplatin INCMGA00012 Nab-paclitaxel 0 1
Carboplatin + INCMGA00012 + Paclitaxel Carboplatin INCMGA00012 Paclitaxel 0 2
Carboplatin + INCMGA00012 + Pemetrexed Carboplatin INCMGA00012 Pemetrexed 0 2
Cisplatin + Gemcitabine + INCMGA00012 Cisplatin Gemcitabine INCMGA00012 0 1
Cisplatin + INCMGA00012 + Pemetrexed Cisplatin INCMGA00012 Pemetrexed 0 2
Epacadostat + INCMGA00012 Epacadostat INCMGA00012 0 1
Fluorouracil + INCMGA00012 + Leucovorin + Margetuximab + Oxaliplatin Fluorouracil INCMGA00012 Leucovorin Margetuximab Oxaliplatin 0 1
INCAGN01876 + INCMGA00012 INCAGN01876 INCMGA00012 0 1
INCMGA00012 INCMGA00012 0 5
INCMGA00012 + Margetuximab INCMGA00012 Margetuximab 0 1
INCMGA00012 + Parsaclisib INCMGA00012 Parsaclisib 0 1
INCMGA00012 + Pemetrexed INCMGA00012 Pemetrexed 0 1
INCMGA00012 + Pemigatinib INCMGA00012 Pemigatinib 0 1


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