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Therapy Name | MGD007 + Retifanlimab |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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MGD007 | MGD007 is a bispecific monoclonal antibody binds to and crosslinks CD3-positive T-cells and gpA33-positive tumor cells to promote antitumor immunity (PMID: 29866746). | |||
Retifanlimab | MGA 012|INCMGA00012|MGA012 | Immune Checkpoint Inhibitor 151 PD-L1/PD-1 antibody 98 | Retifanlimab (INCMGA00012) is a humanized IgG4 monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT085). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT03531632 | Phase Ib/II | MGD007 + Retifanlimab | MGD007 Combined With MGA012 in Relapsed/Refractory Metastatic Colorectal Cancer | Completed | USA | 0 |