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Drug Name Pelareorep
Trade Name
Drug Descriptions

Reolysin (Pelareorep) is a reovirus, which specifically infects and replicates in RAS-activated cells to induce apoptosis, and may also induce anti-tumor immune response (PMID: 29799479).

DrugClasses RAS Inhibitor (Pan) 8
CAS Registry Number 1383626-61-6
NCIT ID C60774


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Avelumab + Paclitaxel + Pelareorep Avelumab Paclitaxel Pelareorep 0 1
Bevacizumab + Fluorouracil + Irinotecan + Leucovorin + Pelareorep Bevacizumab Fluorouracil Irinotecan Leucovorin Pelareorep 0 0
Bevacizumab + Pelareorep Bevacizumab Pelareorep 0 1
Bortezomib + Dexamethasone + Pelareorep Bortezomib Dexamethasone Pelareorep 0 1
Carfilzomib + Dexamethasone + Nivolumab + Pelareorep Carfilzomib Dexamethasone Nivolumab Pelareorep 0 1
Carfilzomib + Dexamethasone + Pelareorep Carfilzomib Dexamethasone Pelareorep 0 1
Docetaxel + Pelareorep Docetaxel Pelareorep 0 1
Fluorouracil + Irinotecan + Leucovorin + Pelareorep Fluorouracil Irinotecan Leucovorin Pelareorep 0 0
Gemcitabine + Pelareorep Gemcitabine Pelareorep 1 0
Irinotecan + Pelareorep Irinotecan Pelareorep 0 0
Paclitaxel + Pelareorep Paclitaxel Pelareorep 0 1
Pelareorep Pelareorep 1 4
Pelareorep + Pembrolizumab Pelareorep Pembrolizumab 0 1
Pelareorep + Pemetrexed Disodium Pelareorep Pemetrexed Disodium 0 1
Pelareorep + Retifanlimab Pelareorep Retifanlimab 0 1

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