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Drug Name Pelareorep
Trade Name
Synonyms REOLYSIN
Drug Descriptions

Reolysin (Pelareorep) is a reovirus, which specifically infects and replicates in RAS-activated cells to induce apoptosis, and may also induce anti-tumor immune response (PMID: 29799479).

DrugClasses RAS Inhibitor (Pan) 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Pelareorep Bevacizumab Pelareorep 0 1
Bortezomib + Dexamethasone + Pelareorep Bortezomib Dexamethasone Pelareorep 0 1
Carfilzomib + Dexamethasone + Nivolumab + Pelareorep Carfilzomib Dexamethasone Nivolumab Pelareorep 0 1
Carfilzomib + Dexamethasone + Pelareorep Carfilzomib Dexamethasone Pelareorep 0 1
Docetaxel + Pelareorep Docetaxel Pelareorep 0 1
Gemcitabine + Pelareorep Gemcitabine Pelareorep 1 0
Irinotecan + Pelareorep Irinotecan Pelareorep 0 0
Pelareorep Pelareorep 1 4
Pelareorep + Pembrolizumab Pelareorep Pembrolizumab 0 1
Pelareorep + Pemetrexed Pelareorep Pemetrexed 0 1


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