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Therapy Name | Goserelin + Pertuzumab + Ribociclib + Trastuzumab |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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Goserelin | Zoladex | Goserelin acetate | Zoladex (goserelin) is a synthetic analog of lutenizing hormone-releasing hormone, which causes decreased testosterone production in males and decreased estradiol production in females, and is FDA approved for use in prostate carcinoma (FDA.gov). | |
Pertuzumab | Perjeta | 2C4 Antibody | HER2 (ERBB2) Antibody 74 | Perjeta (pertuzumab) is a monoclonal antibody that binds ERBB2 (HER2) to prevent dimerization and subsequent HER signaling, thereby resulting in apoptosis and tumor growth inhibition (PMID: 15699478). Perjeta (pertuzumab) is FDA approved in combination with Herceptin (trastuzumab) and Taxotere (docetaxel) for patients with ERBB2 (HER2)-positive breast cancer and in combination with Herceptin (trastuzumab) and chemotherapy as neoadjuvant treatment for patients with ERBB2 (HER2)-positive breast cancer (FDA.gov). |
Ribociclib | Kisqali | LEE011|LEE-011|LEE 011 | CDK4/6 Inhibitor 13 | Kisqali (ribociclib) is a dual CDK4/6 inhibitor, which may induce cell cycle arrest and reduce proliferation in cancer cells (PMID: 24045179). Kisqali (ribociclib) is FDA-approved in combination with an aromatase inhibitor in women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer, and in combination with Faslodex (fulvestrant) in postmenopausal women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer (FDA.gov). |
Trastuzumab | Herceptin | Anti HER2 | HER2 (ERBB2) Antibody 74 | Herceptin (trastuzumab) is a monoclonal antibody, which binds ERBB2 (HER2) to induce tumor cellular cytotoxicity (PMID: 17611206). Herceptin (trastuzumab) is FDA approved for HER2-overexpressing (or amplification) breast cancer, gastric adenocarcinoma, and gastroesophageal junction adenocarcinoma (FDA.gov). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT02344472 | Phase III | Fulvestrant + Pertuzumab + Ribociclib + Trastuzumab Paclitaxel + Pertuzumab + Trastuzumab Docetaxel + Pertuzumab + Trastuzumab Capecitabine + Pertuzumab + Trastuzumab Exemestane + Pertuzumab + Ribociclib + Trastuzumab Letrozole + Pertuzumab + Ribociclib + Trastuzumab Eribulin + Pertuzumab + Trastuzumab Anastrozole + Pertuzumab + Ribociclib + Trastuzumab Goserelin + Pertuzumab + Ribociclib + Trastuzumab Pertuzumab + Trastuzumab + Vinorelbine Nab-paclitaxel + Pertuzumab + Trastuzumab Leuprolide + Pertuzumab + Ribociclib + Trastuzumab | Detect V / CHEVENDO (Chemo vs. Endo) | Active, not recruiting | DEU | 0 |