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Drug Name Pertuzumab
Trade Name Perjeta
Synonyms 2C4 Antibody
Drug Descriptions

Perjeta (pertuzumab) is a monoclonal antibody that binds ERBB2 (HER2) to prevent dimerization and subsequent HER signaling, thereby resulting in apoptosis and tumor growth inhibition (PMID: 15699478). Perjeta (pertuzumab) is FDA approved in combination with Herceptin (trastuzumab) and Taxotere (docetaxel) for patients with ERBB2 (HER2)-positive breast cancer and in combination with Herceptin (trastuzumab) and chemotherapy as neoadjuvant treatment for patients with ERBB2 (HER2)-positive breast cancer (FDA.gov).

DrugClasses HER2 (ERBB2) Antibody 53
CAS Registry Number 380610-27-5
NCIT ID C38692

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Loperamide + Pertuzumab + Trastuzumab Abemaciclib Loperamide Pertuzumab Trastuzumab 0 1
Ado-trastuzumab emtansine + Docetaxel + Pertuzumab Ado-trastuzumab emtansine Docetaxel Pertuzumab 0 0
Ado-trastuzumab emtansine + Pertuzumab Ado-trastuzumab emtansine Pertuzumab 0 4
Alpelisib + Pertuzumab + Trastuzumab Alpelisib Pertuzumab Trastuzumab 0 1
Anastrozole + Carboplatin + Docetaxel + Pertuzumab + Trastuzumab Anastrozole Carboplatin Docetaxel Pertuzumab Trastuzumab 0 0
Anastrozole + Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Trastuzumab Anastrozole Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Trastuzumab 0 0
Anastrozole + Palbociclib + Pertuzumab + Trastuzumab Anastrozole Palbociclib Pertuzumab Trastuzumab 0 1
Anastrozole + Pertuzumab + Ribociclib + Trastuzumab Anastrozole Pertuzumab Ribociclib Trastuzumab 0 1
Anastrozole + Pertuzumab + Trastuzumab + Tucatinib Anastrozole Pertuzumab Trastuzumab Tucatinib 0 1
Atezolizumab + Carboplatin + Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Trastuzumab Atezolizumab Carboplatin Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Trastuzumab 0 1
Atezolizumab + Carboplatin + Paclitaxel + Pertuzumab + Trastuzumab Atezolizumab Carboplatin Paclitaxel Pertuzumab Trastuzumab 0 1
Atezolizumab + Paclitaxel + Pertuzumab + Trastuzumab Atezolizumab Paclitaxel Pertuzumab Trastuzumab 0 3
Atezolizumab + Pertuzumab + Trastuzumab Atezolizumab Pertuzumab Trastuzumab 0 2
Buparlisib + Pertuzumab Buparlisib Pertuzumab 0 0
Buparlisib + Pertuzumab + Trastuzumab Buparlisib Pertuzumab Trastuzumab 0 0
Capecitabine + Cisplatin + Pertuzumab + Trastuzumab Capecitabine Cisplatin Pertuzumab Trastuzumab 0 1
Capecitabine + Pertuzumab + Trastuzumab Capecitabine Pertuzumab Trastuzumab 0 1
Carboplatin + Docetaxel + Exemestane + Pertuzumab + Trastuzumab Carboplatin Docetaxel Exemestane Pertuzumab Trastuzumab 0 0
Carboplatin + Docetaxel + Goserelin + Pertuzumab + Trastuzumab Carboplatin Docetaxel Goserelin Pertuzumab Trastuzumab 0 1
Carboplatin + Docetaxel + Letrozole + Pertuzumab + Trastuzumab Carboplatin Docetaxel Letrozole Pertuzumab Trastuzumab 0 0
Carboplatin + Docetaxel + Metformin + Pertuzumab + Trastuzumab Carboplatin Docetaxel Metformin Pertuzumab Trastuzumab 0 1
Carboplatin + Docetaxel + Pertuzumab + Tamoxifen + Trastuzumab Carboplatin Docetaxel Pertuzumab Tamoxifen Trastuzumab 0 0
Carboplatin + Docetaxel + Pertuzumab + Trastuzumab Carboplatin Docetaxel Pertuzumab Trastuzumab 0 3
Carboplatin + Paclitaxel + Pertuzumab + Trastuzumab Carboplatin Paclitaxel Pertuzumab Trastuzumab 0 2
Cetuximab + Pertuzumab Cetuximab Pertuzumab 0 0
Cisplatin + Fluorouracil + Pertuzumab + Trastuzumab Cisplatin Fluorouracil Pertuzumab Trastuzumab 0 1
Copanlisib + Pertuzumab + Trastuzumab Copanlisib Pertuzumab Trastuzumab 0 1
Cyclophosphamide + Docetaxel + Doxorubicin + Epirubicin + Fluorouracil + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Docetaxel Doxorubicin Epirubicin Fluorouracil Paclitaxel Pertuzumab Trastuzumab 0 1
Cyclophosphamide + Docetaxel + Epirubicin + Fluorouracil + Pertuzumab + Trastuzumab Cyclophosphamide Docetaxel Epirubicin Fluorouracil Pertuzumab Trastuzumab 0 1
Cyclophosphamide + Doxorubicin + Epirubicin + Fluorouracil + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Epirubicin Fluorouracil Pertuzumab Trastuzumab 0 1
Cyclophosphamide + Doxorubicin + Exemestane + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Exemestane Paclitaxel Pertuzumab Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Letrozole + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Letrozole Paclitaxel Pertuzumab Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Tamoxifen + Trastuzumab Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Tamoxifen Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Trastuzumab 0 5
Cyclophosphamide + Doxorubicin + Pertuzumab + Tamoxifen + Trastuzumab Cyclophosphamide Doxorubicin Pertuzumab Tamoxifen Trastuzumab 0 0
Cyclophosphamide + Epirubicin + Fluorouracil + Pertuzumab + Trastuzumab Cyclophosphamide Epirubicin Fluorouracil Pertuzumab Trastuzumab 0 1
Docetaxel + Nivolumab + Pertuzumab + Trastuzumab Docetaxel Nivolumab Pertuzumab Trastuzumab 0 1
Docetaxel + Paclitaxel + Pegfilgrastim + Pertuzumab + Trastuzumab Docetaxel Paclitaxel Pegfilgrastim Pertuzumab Trastuzumab 0 1
Docetaxel + Pertuzumab + Trastuzumab Docetaxel Pertuzumab Trastuzumab 0 7
Durvalumab + Pertuzumab + Trastuzumab Durvalumab Pertuzumab Trastuzumab 0 1
Eribulin + Pertuzumab + Trastuzumab Eribulin Pertuzumab Trastuzumab 0 1
Erlotinib + Pertuzumab Erlotinib Pertuzumab 0 0
Exemestane + Pertuzumab + Ribociclib + Trastuzumab Exemestane Pertuzumab Ribociclib Trastuzumab 0 1
Exemestane + Pertuzumab + Trastuzumab Exemestane Pertuzumab Trastuzumab 0 0
Fulvestrant + Pertuzumab + Ribociclib + Trastuzumab Fulvestrant Pertuzumab Ribociclib Trastuzumab 0 1
Fulvestrant + Pertuzumab + Trastuzumab Fulvestrant Pertuzumab Trastuzumab 0 0
Fulvestrant + Pertuzumab + Trastuzumab + Tucatinib Fulvestrant Pertuzumab Trastuzumab Tucatinib 0 1
Gemcitabine + Pertuzumab + Trastuzumab Gemcitabine Pertuzumab Trastuzumab 0 2
Goserelin + Pertuzumab + Ribociclib + Trastuzumab Goserelin Pertuzumab Ribociclib Trastuzumab 0 1
HER-2/neu intracellular domain protein + Pertuzumab + Polysaccharide-K + Trastuzumab HER-2/neu intracellular domain protein Pertuzumab Polysaccharide-K Trastuzumab 0 1
HER-2/neu intracellular domain protein + Pertuzumab + Trastuzumab HER-2/neu intracellular domain protein Pertuzumab Trastuzumab 0 1
Interferon gamma + Paclitaxel + Pertuzumab + Trastuzumab Interferon gamma Paclitaxel Pertuzumab Trastuzumab 0 1
Ipatasertib + Pertuzumab + Trastuzumab Ipatasertib Pertuzumab Trastuzumab 0 1
Lapatinib + Pertuzumab Lapatinib Pertuzumab 0 0
Letrozole + Palbociclib + Pertuzumab + Trastuzumab Letrozole Palbociclib Pertuzumab Trastuzumab 0 1
Letrozole + Pertuzumab + Ribociclib + Trastuzumab Letrozole Pertuzumab Ribociclib Trastuzumab 0 1
Letrozole + Pertuzumab + Trastuzumab + Tucatinib Letrozole Pertuzumab Trastuzumab Tucatinib 0 1
Leuprolide + Pertuzumab + Ribociclib + Trastuzumab Leuprolide Pertuzumab Ribociclib Trastuzumab 0 1
Lumretuzumab + Pertuzumab Lumretuzumab Pertuzumab 0 0
Margetuximab-cmkb + Paclitaxel + Pertuzumab Margetuximab-cmkb Paclitaxel Pertuzumab 0 1
Nab-paclitaxel + Pertuzumab + Trastuzumab Nab-paclitaxel Pertuzumab Trastuzumab 0 2
Neratinib + Paclitaxel + Pertuzumab + Trastuzumab Neratinib Paclitaxel Pertuzumab Trastuzumab 0 2
Neratinib + Pertuzumab Neratinib Pertuzumab 0 0
Neratinib + Pertuzumab + Trastuzumab Neratinib Pertuzumab Trastuzumab 0 0
Paclitaxel + Pembrolizumab + Pertuzumab + Trastuzumab Paclitaxel Pembrolizumab Pertuzumab Trastuzumab 0 1
Paclitaxel + Pertuzumab Paclitaxel Pertuzumab 0 0
Paclitaxel + Pertuzumab + pUMVC3-IGFBP2-HER2-IGF1R vaccine + Trastuzumab Paclitaxel Pertuzumab Trastuzumab pUMVC3-IGFBP2-HER2-IGF1R vaccine 0 1
Paclitaxel + Pertuzumab + Trastuzumab Paclitaxel Pertuzumab Trastuzumab 0 16
Paclitaxel + Pertuzumab + Trastuzumab + Trastuzumab deruxtecan Paclitaxel Pertuzumab Trastuzumab Trastuzumab deruxtecan 0 1
Pembrolizumab + Pertuzumab + Trastuzumab Pembrolizumab Pertuzumab Trastuzumab 0 1
Pertuzumab Pertuzumab 0 10
Pertuzumab + TAEK-VAC-HerBy + Trastuzumab Pertuzumab TAEK-VAC-HerBy Trastuzumab 0 1
Pertuzumab + Tocilizumab + Trastuzumab Pertuzumab Tocilizumab Trastuzumab 0 1
Pertuzumab + Trastuzumab Pertuzumab Trastuzumab 0 32
Pertuzumab + Trastuzumab + Tucatinib Pertuzumab Trastuzumab Tucatinib 0 0
Pertuzumab + Trastuzumab + Vinorelbine Pertuzumab Trastuzumab Vinorelbine 0 2
Pertuzumab + Trastuzumab deruxtecan Pertuzumab Trastuzumab deruxtecan 0 2


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