Drug Detail

Drug Name Pertuzumab
Trade Name Perjeta
Synonyms 2C4 Antibody
Drug Descriptions

Perjeta (pertuzumab) is a monoclonal antibody that binds ERBB2 (HER2) to prevent dimerization and subsequent HER signaling, thereby resulting in apoptosis and tumor growth inhibition (PMID: 15699478). Perjeta (pertuzumab) is FDA approved in combination with Herceptin (trastuzumab) and Taxotere (docetaxel) for patients with ERBB2 (HER2)-positive breast cancer and in combination with Herceptin (trastuzumab) and chemotherapy as neoadjuvant treatment for patients with ERBB2 (HER2)-positive breast cancer (FDA.gov).

DrugClasses HER2 (ERBB2) Antibody 29

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Loperamide + Pertuzumab + Trastuzumab Abemaciclib Loperamide Pertuzumab Trastuzumab 0 1
Ado-trastuzumab emtansine + Docetaxel + Pertuzumab Ado-trastuzumab emtansine Docetaxel Pertuzumab 1 0
Ado-trastuzumab emtansine + Pertuzumab Ado-trastuzumab emtansine Pertuzumab 0 5
Anastrozole + Carboplatin + Docetaxel + Pertuzumab + Trastuzumab Anastrozole Carboplatin Docetaxel Pertuzumab Trastuzumab 0 0
Anastrozole + Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Trastuzumab Anastrozole Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Trastuzumab 0 0
Anastrozole + Palbociclib + Pertuzumab + Trastuzumab Anastrozole Palbociclib Pertuzumab Trastuzumab 0 1
Atezolizumab + Paclitaxel + Pertuzumab + Trastuzumab Atezolizumab Paclitaxel Pertuzumab Trastuzumab 0 2
Atezolizumab + Pertuzumab + Trastuzumab Atezolizumab Pertuzumab Trastuzumab 0 2
Buparlisib + Pertuzumab Buparlisib Pertuzumab 0 0
Buparlisib + Pertuzumab + Trastuzumab Buparlisib Pertuzumab Trastuzumab 1 0
Capecitabine + Cisplatin + Pertuzumab + Trastuzumab Capecitabine Cisplatin Pertuzumab Trastuzumab 0 0
Carboplatin + Docetaxel + Exemestane + Pertuzumab + Trastuzumab Carboplatin Docetaxel Exemestane Pertuzumab Trastuzumab 0 0
Carboplatin + Docetaxel + Goserelin + Pertuzumab + Trastuzumab Carboplatin Docetaxel Goserelin Pertuzumab Trastuzumab 0 1
Carboplatin + Docetaxel + Letrozole + Pertuzumab + Trastuzumab Carboplatin Docetaxel Letrozole Pertuzumab Trastuzumab 0 0
Carboplatin + Docetaxel + Metformin + Pertuzumab + Trastuzumab Carboplatin Docetaxel Metformin Pertuzumab Trastuzumab 0 1
Carboplatin + Docetaxel + Pertuzumab + Tamoxifen + Trastuzumab Carboplatin Docetaxel Pertuzumab Tamoxifen Trastuzumab 0 0
Carboplatin + Docetaxel + Pertuzumab + Trastuzumab Carboplatin Docetaxel Pertuzumab Trastuzumab 1 3
Carboplatin + Paclitaxel + Pertuzumab + Trastuzumab Carboplatin Paclitaxel Pertuzumab Trastuzumab 0 1
Cetuximab + Pertuzumab Cetuximab Pertuzumab 0 0
Cyclophosphamide + Doxorubicin + Exemestane + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Exemestane Paclitaxel Pertuzumab Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Letrozole + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Letrozole Paclitaxel Pertuzumab Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Tamoxifen + Trastuzumab Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Tamoxifen Trastuzumab 0 0
Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide Doxorubicin Paclitaxel Pertuzumab Trastuzumab 1 2
Cyclophosphamide + Doxorubicin + Pertuzumab + Tamoxifen + Trastuzumab Cyclophosphamide Doxorubicin Pertuzumab Tamoxifen Trastuzumab 0 0
Cyclophosphamide + Epirubicin + Fluorouracil + Pertuzumab + Trastuzumab Cyclophosphamide Epirubicin Fluorouracil Pertuzumab Trastuzumab 0 1
Docetaxel + Nivolumab + Pertuzumab + Trastuzumab Docetaxel Nivolumab Pertuzumab Trastuzumab 0 1
Docetaxel + Paclitaxel + Pegfilgrastim + Pertuzumab + Trastuzumab Docetaxel Paclitaxel Pegfilgrastim Pertuzumab Trastuzumab 0 1
Docetaxel + Pertuzumab + Trastuzumab Docetaxel Pertuzumab Trastuzumab 2 5
Durvalumab + Pertuzumab + Trastuzumab Durvalumab Pertuzumab Trastuzumab 0 1
Erlotinib + Pertuzumab Erlotinib Pertuzumab 0 0
Exemestane + Pertuzumab + Trastuzumab Exemestane Pertuzumab Trastuzumab 0 0
Fulvestrant + Pertuzumab + Trastuzumab Fulvestrant Pertuzumab Trastuzumab 0 0
Gemcitabine + Pertuzumab + Trastuzumab Gemcitabine Pertuzumab Trastuzumab 0 2
HER-2/neu intracellular domain protein + Pertuzumab + Polysaccharide-K + Trastuzumab HER-2/neu intracellular domain protein Pertuzumab Polysaccharide-K Trastuzumab 0 1
HER-2/neu intracellular domain protein + Pertuzumab + Trastuzumab HER-2/neu intracellular domain protein Pertuzumab Trastuzumab 0 1
interferon gamma + Paclitaxel + Pertuzumab + Trastuzumab Paclitaxel Pertuzumab Trastuzumab interferon gamma 0 1
Lapatinib + Pertuzumab Lapatinib Pertuzumab 1 0
Nab-paclitaxel + Pertuzumab + Trastuzumab Nab-paclitaxel Pertuzumab Trastuzumab 0 0
Neratinib + Paclitaxel + Pertuzumab + Trastuzumab Neratinib Paclitaxel Pertuzumab Trastuzumab 0 2
Neratinib + Pertuzumab Neratinib Pertuzumab 1 0
Paclitaxel + Pembrolizumab + Pertuzumab + Trastuzumab Paclitaxel Pembrolizumab Pertuzumab Trastuzumab 0 2
Paclitaxel + Pertuzumab + Trastuzumab Paclitaxel Pertuzumab Trastuzumab 1 9
Pertuzumab Pertuzumab 6 9
Pertuzumab + Tocilizumab + Trastuzumab Pertuzumab Tocilizumab Trastuzumab 0 1
Pertuzumab + Trastuzumab Pertuzumab Trastuzumab 29 22
Pertuzumab + Trastuzumab + Vinorelbine Pertuzumab Trastuzumab Vinorelbine 0 1


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