Therapy Detail
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| Therapy Name | Carboplatin + Paclitaxel + Pertuzumab + Trastuzumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| Paclitaxel | Taxol | 7-Epipaclitaxel | Antimicrotubule Agent 14 BCL2 Family Inhibitor 6 | Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary). |
| Pertuzumab | Perjeta | 2C4 Antibody | HER2 (ERBB2) Antibody 72 | Perjeta (pertuzumab) is a monoclonal antibody that binds ERBB2 (HER2) to prevent dimerization and subsequent HER signaling, thereby resulting in apoptosis and tumor growth inhibition (PMID: 15699478). Perjeta (pertuzumab) is FDA approved in combination with Herceptin (trastuzumab) and Taxotere (docetaxel) for patients with ERBB2 (HER2)-positive breast cancer and in combination with Herceptin (trastuzumab) and chemotherapy as neoadjuvant treatment for patients with ERBB2 (HER2)-positive breast cancer (FDA.gov). |
| Trastuzumab | Herceptin | Anti HER2 | HER2 (ERBB2) Antibody 72 | Herceptin (trastuzumab) is a monoclonal antibody, which binds ERBB2 (HER2) to induce tumor cellular cytotoxicity (PMID: 17611206). Herceptin (trastuzumab) is FDA approved for HER2-overexpressing (or amplification) breast cancer, gastric adenocarcinoma, and gastroesophageal junction adenocarcinoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05188313 | Phase III | Carboplatin + Paclitaxel Carboplatin + Paclitaxel + Pertuzumab + Trastuzumab | TRAstuzumab and Pertuzumab for HER2+ Resectable Oesophageal Cancer (TRAP-2) | Recruiting | NLD | 0 |
| NCT03595592 | Phase III | Carboplatin + Paclitaxel + Pertuzumab + Trastuzumab Atezolizumab + Carboplatin + Paclitaxel + Pertuzumab + Trastuzumab Atezolizumab + Carboplatin + Cyclophosphamide + Doxorubicin + Paclitaxel + Pertuzumab + Trastuzumab | Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer (APTneo) | Active, not recruiting | ITA | ESP | DEU | AUT | 0 |
| NCT02789657 | Phase II | Carboplatin + Paclitaxel + Pertuzumab + Trastuzumab Cyclophosphamide + Doxorubicin | Neoadjuvant Therapy in Clinical Stage I-III HER2-positive Breast Cancer. | Completed | USA | 0 |
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