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Drug Name Copanlisib
Trade Name Aliqopa
Synonyms BAY80-6946
Drug Descriptions

Aliqopa (copanlisib) is a selective PIK3CA and PIK3CD inhibitor that prevents activation of Akt, resulting in inhibition of cell cycle progression and increased apoptosis (PMID: 24013662, PMID: 25528022). Aliqopa (copanlisib) is FDA approved for adult patients with follicular lymphoma (FDA.gov).

DrugClasses PIK3CA inhibitor 16 PIK3CD inhibitor 25

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Copanlisib + Fulvestrant Abemaciclib Copanlisib Fulvestrant 0 1
Bendamustine + Copanlisib + Rituximab Bendamustine Copanlisib Rituximab 0 1
Carboplatin + Copanlisib + Dexamethasone + Gemcitabine + Pegfilgrastim + Rituximab Carboplatin Copanlisib Dexamethasone Gemcitabine Pegfilgrastim Rituximab 0 1
Cisplatin + Copanlisib + Gemcitabine Cisplatin Copanlisib Gemcitabine 0 1
Copanlisib Copanlisib 27 11
Copanlisib + Crizotinib Copanlisib Crizotinib 0 0
Copanlisib + Durvalumab + Olaparib Copanlisib Durvalumab Olaparib 0 1
Copanlisib + Ibrutinib Copanlisib Ibrutinib 0 2
Copanlisib + Ipilimumab + Nivolumab Copanlisib Ipilimumab Nivolumab 0 1
Copanlisib + Letrozole Copanlisib Letrozole 0 1
Copanlisib + Letrozole + Palbociclib Copanlisib Letrozole Palbociclib 0 1
Copanlisib + Niraparib Copanlisib Niraparib 0 1
Copanlisib + Nivolumab Copanlisib Nivolumab 0 6
Copanlisib + Nivolumab + Rituximab Copanlisib Nivolumab Rituximab 0 1
Copanlisib + Paclitaxel Copanlisib Paclitaxel 1 1
Copanlisib + Pertuzumab + Trastuzumab Copanlisib Pertuzumab Trastuzumab 0 1
Copanlisib + Refametinib Copanlisib Refametinib 1 1
Copanlisib + Rituximab Copanlisib Rituximab 0 1
Copanlisib + Rogaratinib Copanlisib Rogaratinib 0 1
Copanlisib + Romidepsin Copanlisib Romidepsin 0 1
Copanlisib + Rucaparib Copanlisib Rucaparib 0 1
Copanlisib + Vemurafenib Copanlisib Vemurafenib 0 1


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