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Drug Name Romidepsin
Trade Name Istodax
Synonyms FK228|FR901228|NSC 630176|depsipeptide
Drug Descriptions

Istodax (romidepsin) inhibits Class I HDACs, resulting in cell cycle arrest, apoptosis, and decreased tumor cell growth (PMID: 12208741, PMID: 12234611, PMID: 21258344). Istodax (romidepsin) is FDA approved for patients with cutaneous T-cell lymphoma (FDA.gov).

DrugClasses HDAC Inhibitor 38

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Dexamethasone + Lenalidomide + Romidepsin Azacitidine Dexamethasone Lenalidomide Romidepsin 0 1
Azacitidine + Durvalumab + Romidepsin Azacitidine Durvalumab Romidepsin 0 1
Azacitidine + Pembrolizumab + Romidepsin Azacitidine Pembrolizumab Romidepsin 0 1
Azacitidine + Romidepsin Azacitidine Romidepsin 0 2
Brentuximab vedotin + Romidepsin Brentuximab vedotin Romidepsin 0 1
Busulfan + Fludarabine + Romidepsin Busulfan Fludarabine Romidepsin 0 1
Cisplatin + Nivolumab + Romidepsin Cisplatin Nivolumab Romidepsin 0 1
Cisplatin + Romidepsin Cisplatin Romidepsin 0 1
Copanlisib + Romidepsin Copanlisib Romidepsin 0 1
Cytarabine + Romidepsin Cytarabine Romidepsin 1 0
Durvalumab + Pralatrexate + Romidepsin Durvalumab Pralatrexate Romidepsin 0 1
Durvalumab + Romidepsin Durvalumab Romidepsin 0 1
Duvelisib + Romidepsin Duvelisib Romidepsin 0 1
Ixazomib + Romidepsin Ixazomib Romidepsin 0 1
Lenalidomide + Rituximab + Romidepsin Lenalidomide Rituximab Romidepsin 0 1
Lenalidomide + Romidepsin Lenalidomide Romidepsin 0 1
MK2206 + Romidepsin MK2206 Romidepsin 0 0
Pegylated liposomal-doxorubicin + Romidepsin Pegylated liposomal-doxorubicin Romidepsin 0 1
Pembrolizumab + Romidepsin Pembrolizumab Romidepsin 0 2
Pralatrexate + Romidepsin Pralatrexate Romidepsin 0 1
Romidepsin Romidepsin 3 8
Romidepsin + Tenalisib Romidepsin Tenalisib 0 1


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