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Drug Name Tenalisib
Trade Name
Synonyms RP6530
Drug Descriptions

Tenalisib (RP6530) is an inhibitor of PIK3CG and PIK3CD, which blocks PI3K/AKT signaling to prevent cell proliferation and also may modulate the tumor microenvironment and induce macrophage phenotype conversion from M2 to M1 (PMID: 30352904, PMID: 31761713, PMID: 32824175).

DrugClasses PIK3CD inhibitor 24 PIK3CG inhibitor 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Pembrolizumab + Tenalisib Pembrolizumab Tenalisib 0 1
Romidepsin + Tenalisib Romidepsin Tenalisib 0 1
Ruxolitinib + Tenalisib Ruxolitinib Tenalisib 1 0
Tenalisib Tenalisib 5 3


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