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Drug Name Pralatrexate
Trade Name FOLOTYN
Drug Descriptions

Pralatrexate is folate analogue inhibitor of dihydrofolate reductase that is selective for cells expressing RFC-1 (which may be overexpressed on cancer cells). Pralatrexate causes depletion of nucleotide precursors; inhibition of DNA, RNA and protein synthesis; and apoptotic tumor cell death (NCI Drug Dictionary).

CAS Registry Number 146464-95-1


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Pralatrexate + Prednisone Brentuximab vedotin Cyclophosphamide Doxorubicin Pralatrexate Prednisone 0 1
Cyclophosphamide + Pralatrexate + Prednisone + Vincristine Sulfate Cyclophosphamide Pralatrexate Prednisone Vincristine Sulfate 0 1
Decitabine + Pembrolizumab + Pralatrexate Decitabine Pembrolizumab Pralatrexate 0 1
Durvalumab + Pralatrexate + Romidepsin Durvalumab Pralatrexate Romidepsin 0 1
Erlotinib + Pralatrexate Erlotinib Pralatrexate 0 1
Pembrolizumab + Pralatrexate Pembrolizumab Pralatrexate 0 2
Pralatrexate Pralatrexate 0 2
Pralatrexate + Romidepsin Pralatrexate Romidepsin 0 1

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