Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Pralatrexate
Trade Name FOLOTYN
Drug Descriptions

Pralatrexate is folate analogue inhibitor of dihydrofolate reductase that is selective for cells expressing RFC-1 (which may be overexpressed on cancer cells). Pralatrexate causes depletion of nucleotide precursors; inhibition of DNA, RNA and protein synthesis; and apoptotic tumor cell death (NCI Drug Dictionary).

CAS Registry Number 146464-95-1


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Brentuximab vedotin + Cyclophosphamide + Doxorubicin + Pralatrexate + Prednisone Brentuximab vedotin Cyclophosphamide Doxorubicin Pralatrexate Prednisone 0 1
Decitabine + Pembrolizumab + Pralatrexate Decitabine Pembrolizumab Pralatrexate 0 1
Durvalumab + Pralatrexate + Romidepsin Durvalumab Pralatrexate Romidepsin 0 1
Erlotinib + Pralatrexate Erlotinib Pralatrexate 0 1
Pembrolizumab + Pralatrexate Pembrolizumab Pralatrexate 0 2
Pralatrexate Pralatrexate 0 2
Pralatrexate + Romidepsin Pralatrexate Romidepsin 0 1

Additional content available in CKB BOOST