Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Duvelisib
Trade Name Copiktra
Synonyms IPI-145|INK1197
Drug Descriptions

Copiktra (duvelisib) prevents the activation of the PI3K delta/gamma-mediated signaling pathways, resulting in tumor cell death (PMID: 25258342). Copiktra (duvelisib) is FDA approved for use in adult patients with relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lymphoma, and follicular lymphoma (FDA.gov)

DrugClasses PIK3CD inhibitor 26 PIK3CG inhibitor 9
CAS Registry Number 1201438-56-3
NCIT ID C99225


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Duvelisib Acalabrutinib Duvelisib 0 1
Azacitidine + Doxorubicin + Duvelisib + Romidepsin Azacitidine Doxorubicin Duvelisib Romidepsin 0 1
Azacitidine + Duvelisib Azacitidine Duvelisib 0 1
Bortezomib + Duvelisib Bortezomib Duvelisib 0 1
Cyclophosphamide + Doxorubicin + Duvelisib + Etoposide + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Duvelisib Etoposide Prednisone Vincristine Sulfate 0 1
Docetaxel + Duvelisib Docetaxel Duvelisib 0 1
Duvelisib Duvelisib 3 13
Duvelisib + Ibrutinib Duvelisib Ibrutinib 0 1
Duvelisib + Nivolumab Duvelisib Nivolumab 0 3
Duvelisib + Obinutuzumab Duvelisib Obinutuzumab 0 1
Duvelisib + Pembrolizumab Duvelisib Pembrolizumab 0 1
Duvelisib + Rituximab Duvelisib Rituximab 0 1
Duvelisib + Romidepsin Duvelisib Romidepsin 0 1
Duvelisib + Ruxolitinib Duvelisib Ruxolitinib 0 1
Duvelisib + unspecified PD-L1 antibody Duvelisib unspecified PD-L1 antibody 0 0
Duvelisib + Venetoclax Duvelisib Venetoclax 0 2

Additional content available in CKB BOOST