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Drug Name Duvelisib
Trade Name Copiktra
Synonyms IPI-145|INK1197
Drug Descriptions

Copiktra (duvelisib) prevents the activation of the PI3K delta/gamma-mediated signaling pathways, resulting in tumor cell death (PMID: 25258342). Copiktra (duvelisib) is FDA approved for use in adult patients with relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lymphoma, and follicular lymphoma (FDA.gov)

DrugClasses PIK3CD inhibitor 26 PIK3CG inhibitor 8
CAS Registry Number 1201438-56-3
NCIT ID C99225


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Duvelisib Acalabrutinib Duvelisib 0 1
Azacitidine + Doxorubicin + Duvelisib + Romidepsin Azacitidine Doxorubicin Duvelisib Romidepsin 0 1
Azacitidine + Duvelisib Azacitidine Duvelisib 0 1
Bortezomib + Duvelisib Bortezomib Duvelisib 0 1
Cyclophosphamide + Doxorubicin + Duvelisib + Etoposide + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Duvelisib Etoposide Prednisone Vincristine Sulfate 0 1
Docetaxel + Duvelisib Docetaxel Duvelisib 0 1
Duvelisib Duvelisib 3 13
Duvelisib + Ibrutinib Duvelisib Ibrutinib 0 1
Duvelisib + Nivolumab Duvelisib Nivolumab 0 3
Duvelisib + Obinutuzumab Duvelisib Obinutuzumab 0 1
Duvelisib + Pembrolizumab Duvelisib Pembrolizumab 0 1
Duvelisib + Rituximab Duvelisib Rituximab 0 1
Duvelisib + Romidepsin Duvelisib Romidepsin 0 1
Duvelisib + Ruxolitinib Duvelisib Ruxolitinib 0 1
Duvelisib + unspecified PD-L1 antibody Duvelisib unspecified PD-L1 antibody 0 0
Duvelisib + Venetoclax Duvelisib Venetoclax 0 2

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