Drug Detail


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Drug Name Duvelisib
Trade Name Copiktra
Synonyms IPI-145|INK1197
Drug Descriptions

Copiktra (duvelisib) prevents the activation of the PI3K delta/gamma-mediated signaling pathways, resulting in tumor cell death (PMID: 25258342). Copiktra (duvelisib) is FDA approved for use in adult patients with relapsed or refractory chronic lymphocytic leukemia, small lymphocytic lymphoma, and follicular lymphoma (FDA.gov)

DrugClasses PIK3CD inhibitor 27 PIK3CG inhibitor 10
CAS Registry Number 1201438-56-3
NCIT ID C99225


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + Duvelisib Acalabrutinib Duvelisib 0 1
Azacitidine + Doxorubicin + Duvelisib + Romidepsin Azacitidine Doxorubicin Duvelisib Romidepsin 0 1
Azacitidine + Duvelisib Azacitidine Duvelisib 0 1
Bortezomib + Duvelisib Bortezomib Duvelisib 0 1
Cyclophosphamide + Doxorubicin + Duvelisib + Etoposide + Prednisone + Vincristine Sulfate Cyclophosphamide Doxorubicin Duvelisib Etoposide Prednisone Vincristine Sulfate 0 1
Docetaxel + Duvelisib Docetaxel Duvelisib 0 1
Duvelisib Duvelisib 3 14
Duvelisib + Ibrutinib Duvelisib Ibrutinib 0 1
Duvelisib + Nivolumab Duvelisib Nivolumab 0 3
Duvelisib + Obinutuzumab Duvelisib Obinutuzumab 0 1
Duvelisib + Pembrolizumab Duvelisib Pembrolizumab 0 1
Duvelisib + Rituximab Duvelisib Rituximab 0 1
Duvelisib + Romidepsin Duvelisib Romidepsin 0 1
Duvelisib + Ruxolitinib Duvelisib Ruxolitinib 0 1
Duvelisib + unspecified PD-L1 antibody Duvelisib unspecified PD-L1 antibody 0 0
Duvelisib + Venetoclax Duvelisib Venetoclax 0 2

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